224 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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    sciencedirect.com/science/article/pii/S258900422401424X
  3. May 2024
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    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
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      DOI: 10.1016/j.cell.2024.01.028

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    sciencedirect.com/science/article/pii/S0092867424000655
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
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    sciencedirect.com/science/article/pii/S2211124724005333
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    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
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    sciencedirect.com/science/article/pii/S1074761324002218
  7. Apr 2024
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    Biochemical Fractionation of Human α-Synuclein in a Drosophila Model of Synucleinopathies
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      DOI: 10.3390/ijms25073643

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    ncbi.nlm.nih.gov/pmc/articles/PMC11011978/
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    Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
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    biorxiv.org/content/10.1101/2024.04.01.587609v1
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    sciencedirect.com/science/article/pii/S2211124724003723
  11. Mar 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
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    FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527600/
  15. Feb 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biochemical fractionation of human α-Synuclein in a Drosophila model of synucleinopathies
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10871193/
  17. Jan 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    1. scibot 24 Jan 2024
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    Glioblastoma and its treatment are associated with extensive accelerated brain aging
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      DOI: 10.1111/acel.14066

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  20. Dec 2023
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    Age-dependent loss of cohesion protection in human oocytes
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    sciencedirect.com/science/article/pii/S0960982223016494
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    Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
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    Mir324 knockout regulates the structure of dendritic spines and impairs hippocampal long-term potentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10713680/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MiR-138-5p Upregulation during Neuronal Maturation Parallels with an Increase in Neuronal Survival
    1
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      DOI: 10.3390/ijms242216509

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  25. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
    1
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    sciencedirect.com/science/article/pii/S1097276523008493
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    Aryl Hydrocarbon Receptor is a Tumor Promoter in MYCN-Amplified Neuroblastoma Cells Through Suppression of Differentiation
    1
    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.isci.2023.108303

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    sciencedirect.com/science/article/pii/S2589004223023805
  28. Oct 2023
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    Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors
    1
    1. scibot 31 Oct 2023
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      DOI: 10.1007/s00018-023-04983-6

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    link.springer.com/article/10.1007/s00018-023-04983-6
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    KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation
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    sciencedirect.com/science/article/pii/S2211124723013335
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    Regulation of STING activity in DNA sensing by ISG15 modification
    1
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      DOI: 10.1016/j.celrep.2023.113277

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  32. www.tandfonline.com www.tandfonline.com
    Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders
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      DOI: 10.1080/21678421.2023.2261979

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    tandfonline.com/doi/abs/10.1080/21678421.2023.2261979
  33. Sep 2023
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    CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
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  35. Aug 2023
  36. www.science.org www.science.org
    In silico protein interaction screening uncovers DONSON’s role in replication initiation
    1
    1. scibot 29 Aug 2023
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      DOI: 10.1126/science.adi3448

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    A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions
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      DOI: 10.1016/j.chembiol.2023.07.018

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    sciencedirect.com/science/article/pii/S2451945623002428
  38. Jul 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
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      DOI: 10.1371/journal.pgen.1010828

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    ncbi.nlm.nih.gov/pmc/articles/PMC10368295/
  40. 52.53.155.43 52.53.155.43
    Reduced histone gene copy number disrupts Drosophila Polycomb function
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      DOI: 10.1093/genetics/iyad106

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  41. Jun 2023
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    Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40
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    sciencedirect.com/science/article/abs/pii/S0969212623001983
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    Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
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    sciencedirect.com/science/article/pii/S266637912300201X
  44. May 2023
  45. www.mdpi.com www.mdpi.com
    Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells
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      DOI: 10.3390/pharmaceutics15051451

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    mdpi.com/1999-4923/15/5/1451
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice
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      DOI: 10.1002/glia.24384

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    onlinelibrary.wiley.com/doi/10.1002/glia.24384
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ubiquitin fusion reporter to monitor muscle proteostasis in C. elegans
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    ncbi.nlm.nih.gov/pmc/articles/PMC10163378/
  48. www.sciencedirect.com www.sciencedirect.com
    Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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      DOI: 10.1016/j.crmeth.2022.100256

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    sciencedirect.com/science/article/pii/S2667237522001291
  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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      DOI: 10.1016/j.isci.2023.106661

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    sciencedirect.com/science/article/pii/S2589004223007381
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    ZFP36-mediated mRNA decay regulates metabolism
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    sciencedirect.com/science/article/pii/S2211124723004229
  52. www.biorxiv.org www.biorxiv.org
    Reduced histone gene copy number disrupts Drosophila Polycomb function
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      DOI: 10.1101/2023.03.28.534544

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    biorxiv.org/content/10.1101/2023.03.28.534544v1
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    Lysine long-chain fatty acylation regulates the TEAD transcription factor
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      DOI: 10.1016/j.celrep.2023.112388

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    sciencedirect.com/science/article/pii/S2211124723003996
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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  55. Mar 2023
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    The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
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  57. Jan 2023
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    Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats
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  59. Dec 2022
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    Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1
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  61. Nov 2022
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis
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    Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication
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    Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice
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    Structural and functional basis of mammalian microRNA biogenesis by Dicer
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  66. Oct 2022
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    Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells
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  68. Sep 2022
  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aversive memory reactivation: A possible role for delta oscillations in the hippocampus–amygdala circuit
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    A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling
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  71. Aug 2022
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    A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing
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    Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
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  74. Jun 2022
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans
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    miR-182-5p Regulates Nogo-A Expression and Promotes Neurite Outgrowth of Hippocampal Neurons In Vitro
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  78. May 2022
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    The Taspase1/Myosin1f-axis regulates filopodia dynamics
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  81. Mar 2022
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sex hormones modulate pathogenic processes in experimental traumatic brain injury
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    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    A coordinate-based co-localization index to quantify and visualize spatial associations in single-molecule localization microscopy
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  88. Feb 2022
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    Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
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    Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas
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    TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells
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  92. Dec 2021
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    Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling
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  94. Nov 2021
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    MAR1 links membrane adhesion to membrane merger during cell-cell fusion in Chlamydomonas
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    The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability
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    1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
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    The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
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    RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts
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  100. Oct 2021
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    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis
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  102. Sep 2021
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
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    TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state
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    Increased fidelity of protein synthesis extends lifespan
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  107. Aug 2021
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    Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling
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    GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
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    Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors
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    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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  154. Mar 2021
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer
    1
    1. scibot 10 Mar 2021
      RRID:AB_477582

      DOI: 10.12688/f1000research.27393.2

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  156. Feb 2021
  157. academic.oup.com academic.oup.com
    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
    2
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      RRID:AB_477582

      DOI: 10.1210/endocr/bqaa214

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      DOI: 10.1210/endocr/bqaa214

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    academic.oup.com/endo/article/162/1/bqaa214/5992137
  158. www.sciencedirect.com www.sciencedirect.com
    Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
    1
    1. scibot 25 Feb 2021
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      DOI: 10.1016/j.celrep.2020.02.102

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  159. www.sciencedirect.com www.sciencedirect.com
    CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
    1
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      RRID:AB_477582

      DOI: 10.1016/j.celrep.2021.108768

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  160. Jan 2021
  161. link.springer.com link.springer.com
    Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model
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      anti-tubulin

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  162. www.sciencedirect.com www.sciencedirect.com
    Prolonged mitosis causes separase deregulation and chromosome nondisjunction
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      DOI: 10.1016/j.celrep.2020.108652

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  163. elifesciences.org elifesciences.org
    Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm
    1
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      RRID:AB_477582

      DOI: 10.7554/eLife.60047

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  164. Dec 2020
  165. academic.oup.com academic.oup.com
    A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
    1
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      anti-Tubulin

      DOI: 10.1093/nar/gkaa1224

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  166. www.sciencedirect.com www.sciencedirect.com
    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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      DOI: 10.1016/j.celrep.2020.108546

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  167. www.sciencedirect.com www.sciencedirect.com
    Ca2+ Release by IP3 Receptors Is Required to Orient the Mitotic Spindle
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      RRID:AB_477582

      DOI: 10.1016/j.celrep.2020.108483

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  168. www.mdpi.com www.mdpi.com
    Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation
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    1. scibot 07 Dec 2020
      RRID:AB_477582

      DOI: 10.3390/antiox9121202

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  169. Oct 2020
  170. www.sciencedirect.com www.sciencedirect.com
    Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner
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      DOI: 10.1016/j.redox.2020.101742

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  171. Sep 2020
  172. www.sciencedirect.com www.sciencedirect.com
    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
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      DOI: 10.7554/eLife.54935

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  174. elifesciences.org elifesciences.org
    Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs
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      RRID:AB_477582

      DOI: 10.7554/eLife.54379

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  175. www.sciencedirect.com www.sciencedirect.com
    Genome-wide Survey of Ribosome Collision
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      DOI: 10.1016/j.celrep.2020.107610

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  176. www.sciencedirect.com www.sciencedirect.com
    FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells
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      DOI: 10.1016/j.immuni.2020.04.002

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    sciencedirect.com/science/article/pii/S1074761320301606
  177. elifesciences.org elifesciences.org
    Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche
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      RRID:AB_477582

      DOI: 10.7554/eLife.42386

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  178. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of the catalytic subunit of DNA‐dependent protein kinase (DNA‐PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses
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    1. scibot 09 Sep 2020
      RRID:AB_477582

      DOI: 10.1002/jcp.29927

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  179. www.sciencedirect.com www.sciencedirect.com
    Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors
    1
    1. scibot 07 Sep 2020
      RRID:AB_477582

      DOI: 10.1016/j.celrep.2020.107535

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  180. www.eneuro.org www.eneuro.org
    Functional Assessment In Vivo of the Mouse Homologue of the Human Ala-9-Ser NHE6 Variant
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    1. scibot 04 Sep 2020
      RRID:AB_477582

      DOI: 10.1523/ENEURO.0046-19.2019

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    eneuro.org/content/6/6/ENEURO.0046-19.2019
  181. link.springer.com link.springer.com
    Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons
    1
    1. scibot 04 Sep 2020
      RRID:AB_477582

      DOI: 10.1007/s12035-020-01957-8

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  182. www.nature.com www.nature.com
    C9orf72 in myeloid cells suppresses STING-induced inflammation
    1
    1. scibot 03 Sep 2020
      tubulin

      DOI: 10.1038/s41586-020-2625-x

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  183. link.springer.com link.springer.com
    Combining the lack of chromogranins with chronic L-DOPA treatment affects motor activity in mice
    1
    1. scibot 03 Sep 2020
      actin

      DOI: 10.1007/s00441-019-03159-8

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  184. Jan 2020
  185. www.sciencedirect.com www.sciencedirect.com
    Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity
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      RRID:AB_477582

      DOI: 10.1016/j.celrep.2019.06.078

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  186. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    Differential effect of glucose on ER-mitochondria Ca2+ exchange participates to insulin secretion and to glucotoxicity-mediated dysfunction of β cells.
    1
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      RRID:AB_477582

      DOI: 10.2337/db18-1112

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    diabetes.diabetesjournals.org/content/68/9/1778
  187. www.sciencedirect.com www.sciencedirect.com
    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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      RRID:AB_477582

      DOI: 10.1016/j.devcel.2019.05.043

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    sciencedirect.com/science/article/pii/S153458071930485X
  188. www.sciencedirect.com www.sciencedirect.com
    NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor
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      DOI: 10.1016/j.celrep.2019.09.087

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  189. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity
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    1. scibot 13 Jan 2020
      RRID:AB_477582

      DOI: 10.1111/jnc.14861

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  190. www.sciencedirect.com www.sciencedirect.com
    Neutral Sphingomyelinase 2 (SMPD3)-Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization
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      RRID:AB_477582

      DOI: 10.1016/j.ajpath.2019.05.008

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  191. www.sciencedirect.com www.sciencedirect.com
    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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      RRID:AB_477582

      DOI: 10.1016/j.celrep.2019.06.054

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  192. www.sciencedirect.com www.sciencedirect.com
    Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade
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      DOI: 10.1016/j.devcel.2019.11.012

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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
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      RRID:AB_477582

      DOI: 10.1523/ENEURO.0419-18.2019

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  194. www.sciencedirect.com www.sciencedirect.com
    Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
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      DOI: 10.1016/j.cell.2019.06.003

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    SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
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      DOI: 10.1016/j.molcel.2019.07.010

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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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      DOI: 10.1016/j.molcel.2019.05.036

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  197. www.sciencedirect.com www.sciencedirect.com
    Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease
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      RRID:AB_477582

      DOI: 10.1016/j.molcel.2019.06.016

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  198. www.sciencedirect.com www.sciencedirect.com
    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
    1
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      DOI: 10.1016/j.celrep.2019.09.023

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