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PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116199
  
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1-s2.0-S2589004225016967-main-html.html

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1. scibot 28 Aug 2025
  
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52.53.155.43/b3f84da895cc36df97322da0dfda604a5cad7552/1-s2.0-S2589004225016967-main-html.html
Aug 2025
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RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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sciencedirect.com/science/article/pii/S0092867425008566
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin

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1. scibot 07 Aug 2025
  
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  DOI: 10.3389/fnana.2025.1625793
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12321798/
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NuMA mechanically reinforces the spindle independently of its partner dynein

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  DOI: 10.1016/j.cub.2025.07.028
  
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sciencedirect.com/science/article/pii/S0960982225008942
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Brain biomechanics governs mitotic fidelity of embryonic neural progenitors

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1. scibot 05 Aug 2025
  
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  DOI: 10.1101/2025.07.31.667957
  
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biorxiv.org/content/10.1101/2025.07.31.667957v1
Jul 2025
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116090
  
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elifesciences.org elifesciences.org

Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

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1. scibot 23 Jul 2025
  
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  DOI: 10.7554/eLife.106469
  
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elifesciences.org/articles/106469
52.53.155.43 52.53.155.43

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113054
  
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52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
Jun 2025
dx.doi.org dx.doi.org

AID–2×RBD27, an auxin-inducible degron-based Rab27 trapper that reversibly inhibits the function of Rab27A in melanocytes

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1. scibot 25 Jun 2025
  
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  DOI: 10.1242/jcs.263878
  
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dx.doi.org/10.1242/jcs.263878
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Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115811
  
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May 2025
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The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus

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1. scibot 31 May 2025
  
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  DOI: 10.1111/jnc.70094
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12120816/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225010132-main-html.html

1
1. scibot 29 May 2025
  
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  RRID:AB_477583
  
  DOI: 10.1016/j.isci.2025.112752
  
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52.53.155.43/9003c45fae7689dd9660ec2260acff69b9d30974/1-s2.0-S2589004225010132-main-html.html
onlinelibrary.wiley.com onlinelibrary.wiley.com

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

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1. scibot 20 May 2025
  
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  DOI: 10.1111/eci.70051
  
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onlinelibrary.wiley.com/doi/10.1111/eci.70051
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115728
  
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sciencedirect.com/science/article/pii/S2211124725004991
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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115695
  
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sciencedirect.com/science/article/pii/S2211124725004668
Apr 2025
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RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115599
  
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sciencedirect.com/science/article/pii/S2211124725003705
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ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

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1. scibot 16 Apr 2025
  
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  DOI: 10.1126/sciadv.adu5091
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980836/
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ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

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  DOI: 10.1126/sciadv.adu5091
  
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science.org/doi/10.1126/sciadv.adu5091
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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

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  DOI: 10.1016/j.molcel.2025.03.015
  
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sciencedirect.com/science/article/pii/S109727652500259X
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Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

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  DOI: 10.1016/j.celrep.2025.115459
  
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sciencedirect.com/science/article/pii/S221112472500230X
Mar 2025
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RNA editing of genomic neighbors controls antiviral response in fungi

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  DOI: 10.1016/j.chom.2025.02.016
  
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sciencedirect.com/science/article/pii/S1931312825000642
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SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.cub.2025.03.003
  
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sciencedirect.com/science/article/pii/S096098222500288X
Feb 2025
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OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

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1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s44319-024-00361-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
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Multivalent afadin interaction promotes IDR-mediated condensate formation and junctional separation of epithelial cells

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115335
  
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Inhibition of GABARAP or GABARAPL1 prevents aminoglycoside- induced hearing loss

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1. scibot 26 Feb 2025
  
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  DOI: 10.1073/pnas.2416453122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11848329/
skeletalmusclejournal.biomedcentral.com skeletalmusclejournal.biomedcentral.com

An RNAi based screen in Drosophila larvae identifies fascin as a regulator of myoblast fusion and myotendinous junction structure

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1. scibot 20 Feb 2025
  
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  DOI: 10.1186/s13395-018-0159-9
  
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skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-018-0159-9
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Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms

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  DOI: 10.1016/j.celrep.2025.115310
  
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

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  DOI: 10.1016/j.celrep.2025.115284
  
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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation

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  DOI: 10.1016/j.celrep.2025.115279
  
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Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.21.614248
  
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52.53.155.43/5ae47209b7006eb85d3adbe5cd2f83306ecd19fd/2024.09.21.614248.full-html.html
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Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.09.612097
  
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52.53.155.43/f05ab403f134b3e958e2f7b12bdc7f45adf9ceaf/2024.09.09.612097v1.full-html.html
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A non-catalytic function for Rad18 in sustaining glioblastoma proliferation

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.05.611406
  
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52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
Jan 2025
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Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals

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1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.stem.2025.01.005
  
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sciencedirect.com/science/article/pii/S1934590925000050
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MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement

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1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.devcel.2023.12.001
  
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A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance

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Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex

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Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy

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Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation

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Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis

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Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

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A famsin-glucagon axis mediates glucose homeostasis

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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

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Tubulin sequence divergence is associated with the use of distinct microtubule regulators

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Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior

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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells

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Linking activation of synaptic NMDA receptors-induced CREB signaling to brief exposure of cortical neurons to oligomeric amyloid-beta peptide

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Scar/WAVE drives actin protrusions independently of its VCA domain using proline-rich domains

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Evolutionarily diverse fungal zoospores show contrasting swimming patterns specific to ultrastructure

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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

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CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

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Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma

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The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

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ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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BCL2L13 at Endoplasmic Reticulum-Mitochondria Contact Sites Regulates Calcium Homeostasis to Maintain Skeletal Muscle Function

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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

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M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival

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Generation and validation of pX-UASTattB for dose-dependent misexpression studies in Drosophila

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wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html

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LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis

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Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

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Cell type-specific and subcellular expression of phospholipid phosphatase-related proteins to modulate lyso-phosphatidic acid synaptic signaling in the developing and adult CNS

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Local file Local file

Untitled document

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  C. Other antibodies used in the study.
  
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Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity

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Trio preserves motor synapses and prolongs motor ability during aging

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Autophagy preferentially degrades non-fibrillar polyQ aggregates

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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

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Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility

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Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

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Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

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Cnicin promotes functional nerve regeneration

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FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins

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IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF

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Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis

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D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation

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A gut-derived hormone regulates cholesterol metabolism

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DNMT3B PWWP mutations cause hypermethylation of heterochromatin

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Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response

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JNEUROSCI.2031-23.2024.full-html.html

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Securin acetylation prevents precocious separase activation and premature sister chromatid separation

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NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP

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The HRI branch of the integrated stress response selectively triggers mitophagy

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Extensive remodeling of the ubiquitination landscape during aging in C. elegans

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Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway

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Dual roles of CCDC102A in governing centrosome duplication and cohesion

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Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells

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EXO1 protects BRCA1-deficient cells against toxic DNA lesions

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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

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Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer

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Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18

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Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

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Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo

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The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

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Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices

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ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells

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Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

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Blocking oligomerization is the most viable strategy to inhibit STING

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Sep 2023
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Assessing crosstalk in simultaneous multicolor single-molecule localization microscopy

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Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

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Aug 2023
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Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function

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Primary adhered neutrophils increase JNK1-MARCKSL1-mediated filopodia to promote secondary neutrophil transmigration

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Golgi-dependent reactivation and regeneration of Drosophila quiescent neural stem cells

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Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

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Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia

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Jul 2023
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Condensate cooperativity underlies transgenerational gene silencing

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Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

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Detection of endogenous translesion DNA synthesis in single mammalian cells

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A mitochondrial iron-responsive pathway regulated by DELE1

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A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

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Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control

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Restored autophagy is protective against PAK3-induced cardiac dysfunction

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Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

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Deneddylating enzyme SENP8 regulates neuronal development

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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

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Journal of Neurochemistry - 2023 - Secker - The polyphenol EGCG directly targets intracellular amyloid‐ aggregates and-html.html

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Protocol to determine the subcellular localization of protein interactions in murine keratinocytes

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16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice

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Androgen Affects the Inhibitory Avoidance Memory by Primarily Acting on Androgen Receptor in the Brain in Adolescent Male Rats

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FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress

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ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis

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Two Hippo signaling modules orchestrate liver size and tumorigenesis

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Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm

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Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays

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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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Jan 2023
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Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling

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Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

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SSRN-id4239126-html.html

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Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates

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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

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Quantification of substoichiometric tRNA modification sites reveals global hypomodification of tsRNA, indicates preferences for angiogenin-mediated tRNA cleavage, and points to idiosyncratic tRNA epitranscriptomes of human neuronal cell lines

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Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

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AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer

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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation

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Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system

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Chemical modulation of microtubule structure through the laulimalide/peloruside site

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Stiffness of primordial germ cells is required for their extravasation in avian embryos

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Assembly and stability of IFT-B complex and its function in BBSome trafficking

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Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

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MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

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The phenotypic landscape of essential human genes

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Mild Traumatic Brain Injury/Concussion Initiates an Atypical Astrocyte Response Caused by Blood–Brain Barrier Dysfunction

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Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

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A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

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Opto-katanin, an optogenetic tool for localized, microtubule disassembly

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A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity

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SMN controls neuromuscular junction integrity through U7 snRNP

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RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss

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An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis

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Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition

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Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

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Mapping of STB/HAP1 immunoreactivity in the mouse brainstem and its relationships with choline acetyltransferase, with special emphasis on cranial nerve motor and preganglionic autonomic nuclei

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Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line

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Contribution of septins to human platelet structure and function

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Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

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ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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A light-sensing system in the common ancestor of the fungi

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Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

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Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

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The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface

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Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors

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Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

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Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

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circMbl functions in cis and in trans to regulate gene expression and physiology in a tissue-specific fashion

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Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB

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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

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WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

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Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition

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Bacteriocyte development is sexually differentiated in Bemesia tabaci

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RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration

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A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle

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Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

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De novo phosphatidylcholine synthesis in the small intestinal epithelium is required for normal dietary lipid handling and maintenance of the mucosal barrier

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Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals

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RNA N6-methyladenosine modification promotes auxin biosynthesis required for male meiosis in rice

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Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis

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