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Aug 2025
www.biorxiv.org www.biorxiv.org

Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients

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  DOI: 10.1101/2025.07.29.667411
  
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biorxiv.org/content/10.1101/2025.07.29.667411v1
Jul 2025
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Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy

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  DOI: 10.1111/bph.17411
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12225536/
Jun 2025
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Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity

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  DOI: 10.1083/jcb.201805099
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6400570/
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2025.05.09.653127v1.full-html.html

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  DOI: 10.1101/2025.05.09.653127
  
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52.53.155.43/f045d568f094d2bc279f23f0cf17ba4e82070137/2025.05.09.653127v1.full-html.html
May 2025
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A conserved role for centriolar satellites in translation of centrosomal and ciliary proteins

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pmc.ncbi.nlm.nih.gov/articles/PMC12094185/
52.53.155.43 52.53.155.43

Maintenance of niche architecture requires actomyosin and enables proper stem cell signaling and oriented division in the Drosophila testis

1
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  DOI: 10.1242/dev.204498
  
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52.53.155.43/442723e37a523d2991c9f6bd8f90711142895143/dev204498supp-html.html
journals.biologists.com journals.biologists.com

Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules

1
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journals.biologists.com/bio/article/13/12/bio061743/363466/Age-and-oxidative-stress-induced-centrosome
Apr 2025
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The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome

1
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  DOI: 10.1016/j.celrep.2024.114688
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12005378/
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Oncogenic KRAS Addiction States Differentially Influence MTH1 Expression and 8-oxodGTPase Activity in Lung Adenocarcinoma

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sciencedirect.com/science/article/pii/S2213231725001235
Mar 2025
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Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

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pmc.ncbi.nlm.nih.gov/articles/PMC11450323/
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A microglia clonal inflammatory disorder in Alzheimer’s disease

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  DOI: 10.7554/eLife.96519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
elifesciences.org elifesciences.org

A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

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  DOI: 10.7554/eLife.98704
  
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elifesciences.org/articles/98704
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Targeting TUBG1 in RB1-negative tumors

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  DOI: 10.1096/fj.202403180RR
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11869804/
Feb 2025
elifesciences.org elifesciences.org

A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

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  DOI: 10.7554/eLife.98704.2
  
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elifesciences.org/reviewed-preprints/98704
Jan 2025
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Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex

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  DOI: 10.1038/s44318-024-00327-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11729872/
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The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis

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  DOI: 10.1016/j.cub.2024.11.056
  
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sciencedirect.com/science/article/pii/S0960982224016233
Dec 2024
journals.biologists.com journals.biologists.com

Age- and oxidative stress-induced centrosome amplification and renal stones in Drosophila Malpighian tubules

1
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journals.biologists.com/bio/article/13/12/bio061743/363466/Age-and-oxidative-stress-induced-centrosome
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

H4K20me3-Mediated Repression of Inflammatory Genes is a Characteristic and Targetable Vulnerability of Persister Cancer Cells

1
1. scibot 13 Dec 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-0529
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617193/
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Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

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  DOI: 10.1038/s44321-024-00161-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
Nov 2024
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CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

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  DOI: 10.1038/s44318-024-00240-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
52.53.155.43 52.53.155.43

can-24-0529-html.html

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  DOI: 10.1158/0008-5472.can-24-0529
  
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52.53.155.43/4faeafb6ce934469a644c8bc705adf42bb41b860/can-24-0529-html.html
Sep 2024
www.cell.com www.cell.com

CDK5RAP2 activates microtubule nucleator γTuRC by facilitating template formation and actin release

1
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cell.com/developmental-cell/fulltext/S1534-5807(24)00529-X
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Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

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sciencedirect.com/science/article/pii/S2589004224020947
Aug 2024
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An actomyosin network organizes niche morphology and responds to feedback from recruited stem cells

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sciencedirect.com/science/article/pii/S0960982224009448
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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

1
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  DOI: 10.7554/eLife.84875
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11296703/
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GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy

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  DOI: 10.1016/s0002-9270(97)00059-2
  
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cell.com/action/showExperimentalProcedures
Jul 2024
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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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sciencedirect.com/science/article/pii/S1534580724003794
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Wg/Wnt-signaling-induced nuclear translocation of β-catenin is attenuated by a β-catenin peptide through its interference with the IFT-A complex

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  DOI: 10.1016/j.celrep.2024.114362
  
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cell.com/cell-reports/abstract/S2211-1247(24)00690-9
Jun 2024
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TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

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  DOI: 10.1016/j.cell.2024.05.030
  
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sciencedirect.com/science/article/pii/S0092867424005750
May 2024
52.53.155.43 52.53.155.43

Centriolar satellites are sites of translation of centrosomal and ciliary proteins

1
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  DOI: 10.1101/2024.02.22.581531
  
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52.53.155.43/b4facf67b457be9515b769549e8e513b0c45add0/2024.02.22.581531v1.full-html.html
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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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  DOI: 10.1016/j.cmet.2024.04.015
  
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sciencedirect.com/science/article/pii/S1550413124001359
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Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

1
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  DOI: 10.7554/eLife.84875.2
  
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elifesciences.org/reviewed-preprints/84875
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Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

1
1. scibot 03 May 2024
  
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  DOI: 10.7554/eLife.89100
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
Apr 2024
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PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response

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  DOI: 10.1016/j.ebiom.2024.105129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
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Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy

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  DOI: 10.1016/j.isci.2024.109580
  
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Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

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Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders

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In vivo CRISPR screening directly targeting testicular cells

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Loss of synaptopodin impairs mGluR5 and protein synthesis–dependent mGluR-LTD at CA3-CA1 synapses

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Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance

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Dual roles of CCDC102A in governing centrosome duplication and cohesion

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Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo

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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1

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FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress

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Loss of synaptopodin impairs mGluR5 and protein synthesis dependent mGluR-LTD at CA3-CA1 synapses

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Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation

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Spd-2 gene duplication reveals cell-type-specific pericentriolar material regulation

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A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans

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Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

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Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2

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Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars

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Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

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Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

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Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila

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IFT-A structure reveals carriages for membrane protein transport into cilia

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CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

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Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities

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Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells

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RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA

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Self-assembly of pericentriolar material in interphase cells lacking centrioles

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A function for Ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

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Increased microtubule growth triggered by microvesicle-mediated paracrine signaling is required for melanoma cancer cell invasion

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The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

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BARS Influences Neuronal Development by Regulation of Post-Golgi Trafficking

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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

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Augmin-dependent microtubule self-organization drives kinetochore fiber maturation in mammals

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Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis

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Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche

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Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis

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Stabilization of Spine Synaptopodin by mGluR1 Is Required for mGluR-LTD

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SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ

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Prickle isoform participation in distinct polarization events in the Drosophila eye

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TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification

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Microtubule organizing centers regulate spindle positioning in mouse oocytes

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chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche

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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

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De novo identification of mammalian ciliary motility proteins using cryo-EM

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STING nuclear partners contribute to innate immune signaling responses

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Cilium induction triggers differentiation of glioma stem cells

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Dual role for CXCL12 signaling in semilunar valve development

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The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms

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Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

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Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

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GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy

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Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

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TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

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Rab34 is necessary for early stages of intracellular ciliogenesis

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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling

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Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

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Acto-myosin network geometry defines centrosome position

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Vertebrate cells differentially interpret ciliary and extraciliary cAMP

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LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

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Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling

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Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions

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Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage

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The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability

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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

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Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells

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The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina

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CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression

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Dynamic Buffering of Extracellular Chemokine by a Dedicated Scavenger Pathway Enables Robust Adaptation during Directed Tissue Migration

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Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

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Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila

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The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress

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Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation

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Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

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Prickle isoforms determine handedness of helical morphogenesis

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NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesisNCAM regulates temporal NPC specification

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C3G localizes to mother centriole dependent on cenexin, and regulates centrosome duplication and primary cilia length

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clincancerres.aacrjournals.org clincancerres.aacrjournals.org

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

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Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions

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MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex

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The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

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Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

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A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

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The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

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Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity

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Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex

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Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

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Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

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Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1

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Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

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Spindle-Length-Dependent HURP Localization Allows Centrosomes to Control Kinetochore-Fiber Plus-End Dynamics

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Cordycepin improves behavioral‐LTP and dendritic structure in hippocampal CA1 area of rats

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Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

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Chiral Cilia Orientation in the Left-Right Organizer

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Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM

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CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

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WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis

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Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

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Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

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Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages

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Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids

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Control of endothelial cell polarity and sprouting angiogenesis by non-centrosomal microtubules

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Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture

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Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

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Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.

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Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

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An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation

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Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis

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Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression

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sciencedirect.com/science/article/pii/S1931312817302494
link.springer.com link.springer.com

IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents

1
1. scibot 08 Nov 2017
  
  in Public
  
  RRID:AB_477584
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
  SciCrunch record: RRID:AB_477584
  
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link.springer.com/article/10.1007/s00125-017-4345-9
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
  SciCrunch record: RRID:AB_477584
  
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  RRID:AB_477584 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0960982217307236
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Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
  SciCrunch record: RRID:AB_477584
  
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  RRID:AB_477584 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627317300934
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NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
  Curator: @Zeljana_Babic
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
  SciCrunch record: RRID:AB_477584
  
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sciencedirect.com/science/article/pii/S1097276517300424
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Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
  Curator: @gabimpine
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
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sciencedirect.com/science/article/pii/S0896627316310418
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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
  Curator: @gabimpine
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
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sciencedirect.com/science/article/pii/S0092867416317482
www.cell.com www.cell.com

GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_477584
  
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  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
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cell.com/action/showExperimentalProcedures
elifesciences.org elifesciences.org

Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

1
1. scibot 08 Nov 2017
  
  in Public
  
  Mouse anti-γ-tubulin (clone GTU-88)
  
  Curator: @jcabotaj
  
  Resource used:
  
  (Sigma-Aldrich Cat# T6557, RRID:AB_477584)
  
  SciCrunch record: RRID:AB_477584
  
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elifesciences.org/content/4/e04796

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