124 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    sciencedirect.com/science/article/pii/S1550413124000536
  3. Mar 2024
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    All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals
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    sciencedirect.com/science/article/pii/S2667237524000651
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    sciencedirect.com/science/article/pii/S1097276524001291
  7. Jan 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772350/
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    Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex
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      DOI: 10.1016/j.celrep.2023.113639

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    sciencedirect.com/science/article/pii/S2211124723016509
  10. Dec 2023
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1002/advs.202305035

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305035
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    Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
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  13. Oct 2023
  14. link.springer.com link.springer.com
    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
    1
    1. scibot 31 Oct 2023
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      DOI: 10.1186/s13041-023-01064-4

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    link.springer.com/article/10.1186/s13041-023-01064-4
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    Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
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    1. scibot 28 Oct 2023
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  16. Aug 2023
  17. www.biorxiv.org www.biorxiv.org
    Acylation of MLKL impacts its function in necroptosis
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    1. scibot 28 Aug 2023
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    biorxiv.org/content/10.1101/2023.08.19.553906v1
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages
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    1. scibot 26 Aug 2023
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      DOI: 10.1126/sciimmunol.abo4767

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    E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
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    sciencedirect.com/science/article/pii/S1097276523005634
  20. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
    2
    1. scibot 17 Aug 2023
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  21. 52.53.155.43 52.53.155.43
    ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis
    2
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  22. Jul 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Structural basis for membrane-proximal proteolysis of substrates by ADAM10
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      DOI: 10.1016/j.cell.2023.06.026

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    sciencedirect.com/science/article/abs/pii/S009286742300733X
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    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
    1
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      DOI: 10.1016/j.celrep.2023.112807

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    sciencedirect.com/science/article/pii/S2211124723008185
  25. May 2023
  26. elifesciences.org elifesciences.org
    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
    1
    1. scibot 21 May 2023
      RRID:AB_490778

      DOI: 10.7554/eLife.82057

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    elifesciences.org/articles/82057
  27. www.nature.com www.nature.com
    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
    1
    1. scibot 20 May 2023
      RRID:AB_490778

      DOI: 10.1038/s41467-023-38605-3

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    nature.com/articles/s41467-023-38605-3
  28. www.sciencedirect.com www.sciencedirect.com
    Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation
    1
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    sciencedirect.com/science/article/pii/S2211124723005016
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcineurin associates with centrosomes and regulates cilia length maintenance
    1
    1. scibot 09 May 2023
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      DOI: 10.1242/jcs.260353

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    ncbi.nlm.nih.gov/pmc/articles/PMC10163345/
  30. Apr 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
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      DOI: 10.1016/j.neuron.2023.04.001

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  32. www.science.org www.science.org
    Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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      DOI: 10.1126/sciadv.ade3422

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  33. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
    1
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  35. Mar 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
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    The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells
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    FAM193A is a positive regulator of p53 activity
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      DOI: 10.1016/j.celrep.2023.112230

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  39. Jan 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly
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      DOI: 10.1016/j.isci.2022.105667

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    ncbi.nlm.nih.gov/pmc/articles/PMC9823123/
  41. Dec 2022
  42. www.sciencedirect.com www.sciencedirect.com
    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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  43. Nov 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
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      DOI: 10.7554/eLife.81606

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    ncbi.nlm.nih.gov/pmc/articles/PMC9651953/
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
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    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    sciencedirect.com/science/article/pii/S2211124722014656
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
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  48. Aug 2022
  49. www.sciencedirect.com www.sciencedirect.com
    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
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      DOI: 10.1016/j.isci.2022.104923

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    sciencedirect.com/science/article/pii/S2589004222011956
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
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    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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  53. Jul 2022
  54. academic.oup.com academic.oup.com
    Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells
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      DOI: 10.1210/endocr/bqac091

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    A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand
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  56. Jun 2022
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    Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome
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  58. May 2022
  59. www.sciencedirect.com www.sciencedirect.com
    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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    Chl1 coordinates with H3K9 methyltransferase Clr4 to reduce the accumulation of RNA-DNA hybrids and maintain genome stability
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  61. Apr 2022
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    A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats
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      DOI: 10.1097/j.pain.0000000000002119

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  64. Mar 2022
  65. www.sciencedirect.com www.sciencedirect.com
    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
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  67. Feb 2022
  68. www.sciencedirect.com www.sciencedirect.com
    TMEM106A inhibits enveloped virus release from cell surface
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  69. Jan 2022
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1
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      DOI: 10.1098/rsob.210103

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  71. Nov 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
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    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
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  74. Oct 2021
  75. www.sciencedirect.com www.sciencedirect.com
    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
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      RRID:AB_490778

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    Biosensors based on peptide exposure show single molecule conformations in live cells
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  77. Sep 2021
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    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
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      RRID:AB_490778

      DOI: 10.1016/j.celrep.2021.109725

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  79. Aug 2021
  80. www.embopress.org www.embopress.org
    A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication
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      RRID:AB_490778

      DOI: 10.15252/embj.2021107664

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  81. www.sciencedirect.com www.sciencedirect.com
    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
    1
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      RRID:AB_490778

      DOI: 10.1016/j.molcel.2018.11.017

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  82. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_490778

      DOI: 10.1016/j.celrep.2018.10.049

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  83. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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      DOI: 10.1038/s41467-021-24687-4

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  84. www.sciencedirect.com www.sciencedirect.com
    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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      RRID:AB_10693332

      DOI: 10.1016/j.celrep.2019.08.076

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      RRID:AB_490778

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    Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel
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      RRID:AB_10693332

      DOI: 10.1016/j.neuron.2019.08.041

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  87. Jul 2021
  88. www.sciencedirect.com www.sciencedirect.com
    Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action
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      Rabbit Myc (71D10) [1:5000]

      DOI: 10.1016/j.celrep.2019.10.115

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  89. europepmc.org europepmc.org
    TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.
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      RRID:AB_490778

      DOI: 10.7554/eLife.23242

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  90. www.sciencedirect.com www.sciencedirect.com
    Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication
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    BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
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    ncbi.nlm.nih.gov/pmc/articles/PMC6261462/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells
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      DOI: 10.7554/eLife.24318

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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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  94. Jun 2021
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex
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      RRID:AB_490778

      DOI: 10.7554/eLife.66739

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  96. www.sciencedirect.com www.sciencedirect.com
    CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells
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  97. May 2021
  98. www.sciencedirect.com www.sciencedirect.com
    Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment
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      RRID:AB_490778

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  99. www.tandfonline.com www.tandfonline.com
    CREG1 promotes lysosomal biogenesis and function
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      RRID:AB_490778

      DOI: 10.1080/15548627.2021.1909997

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    ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
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    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
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      RRID:AB_490778

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    Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling
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  103. Apr 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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      rabbit anti-Myc-Tag

      DOI: 10.1016/j.cmet.2020.08.016

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    TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation
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    Bioorthogonal dissection of the replicase assembly of hepatitis C virus
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      RRID:AB_490778

      DOI: 10.1016/j.chembiol.2021.03.006

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  107. Feb 2021
  108. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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      RRID:AB_490778

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    Live Imaging Reveals Listeria Hijacking of E-Cadherin Recycling as It Crosses the Intestinal Barrier
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    Distinct Roles and Synergistic Function of FruM Isoforms in Drosophila Olfactory Receptor Neurons
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    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
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    Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
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    CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
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    N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1
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    A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling
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    Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
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    TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells
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    Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis
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    Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models
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    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
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    The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
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    HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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  128. onlinelibrary.wiley.com onlinelibrary.wiley.com
    C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms
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    Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation
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    A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
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    Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel
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      DOI: 10.1016/j.neuron.2019.08.041

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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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      DOI: 10.1016/j.ccell.2019.10.002

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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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      DOI: 10.1016/j.immuni.2019.11.015

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    Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation
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    Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis
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  146. Nov 2018
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    Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice
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    Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development
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    Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain
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  150. Nov 2017
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    Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium
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    Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eIF4A inactivates TORC1 in response to amino acid starvation
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    Dlg5 Regulates Dendritic Spine Formation and Synaptogenesis by Controlling Subcellular N-Cadherin Localization
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    ncbi.nlm.nih.gov/pmc/articles/PMC4166160/