128 Matching Annotations
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    Dishevelled drives disassembly of primary cilia through an unusual PDZ domain–mediated binding mode with Girdin-L
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    science.org/doi/10.1126/scisignal.aed1808
  3. Jul 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion
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  6. May 2026
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    It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages
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  8. Apr 2026
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    Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1
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  11. Feb 2026
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    SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism
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    Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation
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  17. Oct 2025
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    Phosphorylation of Plectin by Akt3 Promotes Triple-Negative Breast Cancer Cell Invasive Migration
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    Dishevelled drives Wnt-stimulated disassembly of primary cilia through a unique PDZ-mediated binding mode with Daple and Girdin
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  20. Sep 2025
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    Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice
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    GPR65 Functions as a Key Factor of Bone Aging and a Novel Therapeutic Target for Osteoporosis
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    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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    EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
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  29. May 2025
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    Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
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  31. Mar 2025
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    PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  39. Oct 2024
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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  41. Aug 2024
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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  46. Jul 2024
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    Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
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  48. May 2024
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    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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  50. Apr 2024
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    Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis
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  53. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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  55. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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  57. Jun 2023
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    Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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  61. May 2023
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    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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    GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
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  65. Apr 2023
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    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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  67. Mar 2023
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  70. Feb 2023
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    Hexane fraction of Prunus japonica thunb. Seed extract enhances boar sperm motility via CatSper ion channel
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  72. Jan 2023
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    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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  75. Dec 2022
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    PERIOD 2 Regulates Low Dose Radioprotection via PER2/pGSK3β/β-Catenin/Per2 Loop
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  78. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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  81. Aug 2022
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  83. Jul 2022
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  86. Jun 2022
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  88. May 2022
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    c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity
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  92. Apr 2022
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    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
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  94. Feb 2022
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    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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  97. Sep 2021
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    Doxazosin and erlotinib have anticancer effects in the endometrial cancer cell and important roles in ERα and Wnt/β-catenin signaling pathways
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  99. Aug 2021
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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  105. Jul 2021
  106. academic.oup.com academic.oup.com
    Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance
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    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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  112. May 2021
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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  118. Mar 2021
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  120. Feb 2021
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
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  123. Jan 2021
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  125. Dec 2020
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    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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  127. Nov 2020
  128. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model
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  129. Oct 2020
  130. link.springer.com link.springer.com
    Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  132. Sep 2020
  133. dev.biologists.org dev.biologists.org
    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
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  136. www.mdpi.com www.mdpi.com
    Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species
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  137. www.sciencedirect.com www.sciencedirect.com
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    Effect of angiotensin II and angiotensin‐(1–7) on proliferation of stem cells from human dental apical papilla
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    FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and β-catenin activity in ovarian cancer
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  142. Jan 2020
  143. www.sciencedirect.com www.sciencedirect.com
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    Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling
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    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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  154. Nov 2018
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    Early-Ethanol Exposure Induced Region-Specific Changes in Metabolic Proteins in the Rat Brain: A Proteomics Study
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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  164. Nov 2017
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    Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
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    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
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    Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
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    Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
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    Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′s disease
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    Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway
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    Early ethanol exposure and vinpocetine treatment alter learning‐ and memory‐related proteins in the rat hippocampus and prefrontal cortex
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    Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment: Chronobiology International: Vol 32, No 8
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