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Aug 2025
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A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy

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  DOI: 10.1016/j.celrep.2025.116172
  
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sciencedirect.com/science/article/pii/S221112472500943X
Jul 2025
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Distinct adipose progenitor cells emerging with age drive active adipogenesis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/science.adj0430
  
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science.org/doi/10.1126/science.adj0430
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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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  DOI: 10.1016/j.ccell.2025.06.011
  
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sciencedirect.com/science/article/pii/S1535610825002612
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Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans

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  DOI: 10.1016/j.celrep.2025.115933
  
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sciencedirect.com/science/article/pii/S2211124725007041
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The immune response against cancer is modulated by stromal cell fibronectin

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  DOI: 10.1016/j.neo.2025.101196
  
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sciencedirect.com/science/article/pii/S1476558625000764
Jun 2025
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Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis

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  DOI: 10.1016/j.immuni.2025.05.007
  
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sciencedirect.com/science/article/pii/S1074761325002286
May 2025
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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sciencedirect.com/science/article/pii/S2211124725005042
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Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115609
  
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sciencedirect.com/science/article/pii/S2211124725003808
Apr 2025
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Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.devcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1534580725001558
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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  DOI: 10.1158/1078-0432.CCR-23-3616
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Mar 2025
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52.53.155.43/6ffb1e8f8e61cda81dc9b10ac8db2b4f9e212959/PDF-html.html
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Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis

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  DOI: 10.1016/j.celrep.2025.115356
  
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cell.com/cell-reports/abstract/S2211-1247(25)00127-5
Feb 2025
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A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115301
  
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sciencedirect.com/science/article/pii/S2211124725000725
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Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115281
  
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sciencedirect.com/science/article/pii/S221112472500052X
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Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

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  DOI: 10.1016/j.ccell.2025.01.004
  
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sciencedirect.com/science/article/pii/S1535610825000224
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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

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  DOI: 10.1016/j.immuni.2025.01.009
  
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sciencedirect.com/science/article/pii/S1074761325000342
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Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells

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  DOI: 10.1016/j.celrep.2025.115247
  
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sciencedirect.com/science/article/pii/S221112472500018X
Jan 2025
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MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101922
  
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sciencedirect.com/science/article/pii/S2666379124006931
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Phenotypic plasticity and increased infiltration of peripheral blood-derived TREM1+ mono-macrophages following radiotherapy in rectal cancer

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101887
  
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sciencedirect.com/science/article/pii/S266637912400658X
Dec 2024
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Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion

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  DOI: 10.1016/j.heliyon.2024.e40515
  
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sciencedirect.com/science/article/pii/S2405844024165462
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IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages

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  DOI: 10.1016/j.celrep.2024.115039
  
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sciencedirect.com/science/article/pii/S2211124724013901
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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

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sciencedirect.com/science/article/pii/S2211124724013664
Nov 2024
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Stepwise Ultra-pH-Sensitive Micelles Overcome a pKa Barrier for Systemic Lymph Node Delivery

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1. scibot 29 Nov 2024
  
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  DOI: 10.1021/acsnano.4c00876
  
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pubs.acs.org/doi/10.1021/acsnano.4c00876
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
Oct 2024
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CCL28 modulates neutrophil responses during infection with mucosal pathogens

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  DOI: 10.7554/eLife.78206
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11444682/
Aug 2024
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Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.76940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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Stepwise Ultra-pH-Sensitive Micelles Overcome a pKa Barrier for Systemic Lymph Node Delivery

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  DOI: 10.1021/acsnano.4c00876
  
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pubs.acs.org/doi/10.1021/acsnano.4c00876
Jul 2024
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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

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  DOI: 10.1016/j.cmet.2024.06.006
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00231-6
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Glucose transporter 1 is essential for the resolution of methicillin-resistant S. aureus skin and soft tissue infections

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  DOI: 10.1016/j.celrep.2024.114486
  
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sciencedirect.com/science/article/pii/S2211124724008155
May 2024
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Ependymal cells undergo astrocyte-like reactivity in response to neuroinflammation

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  DOI: 10.1111/jnc.16120
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16120
Apr 2024
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A dopamine D1-like receptor-specific agonist improves the survival of septic mice

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  DOI: 10.1016/j.isci.2024.109587
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11016908/
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Expression of a mutant CD47 protects against phagocytosis without inducing cell death or inhibiting angiogenesis

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  DOI: 10.1016/j.xcrm.2024.101450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983038/
Feb 2024
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Gut complement induced by the microbiota combats pathogens and spares commensals

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  DOI: 10.1016/j.cell.2023.12.036
  
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sciencedirect.com/science/article/pii/S0092867424000011
Jan 2024
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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

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  DOI: 10.1016/j.devcel.2023.07.025
  
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  DOI: 10.1016/j.devcel.2023.07.025
  
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sciencedirect.com/science/article/pii/S1534580723003945
Dec 2023
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Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation

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  DOI: 10.1016/j.cmet.2023.11.012
  
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Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition

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Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.

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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

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CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax

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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

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A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke

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Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation

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Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells

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An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

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A neutrophil response linked to tumor control in immunotherapy

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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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Whole-mount immunofluorescence imaging and isolation of mesothelium-bound immune cell aggregates during mouse peritoneal inflammation

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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions

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Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

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DLL3 regulates Notch signaling in small cell lung cancer

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Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

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Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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Unravelling the sex-specific diversity and functions of adrenal gland macrophages

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Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination

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Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model

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TNFɑ Antagonist in Combination with PD-1 Blocker to Prevent or Retard Malignant Transformation of B[a]P-induced Chronic Lung Inflammation

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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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Tumor-derived Jagged1 promotes cancer progression through immune evasion

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Interferon-γ promotes monocyte-mediated lung injury during influenza infection

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In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells

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GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity

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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

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Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

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Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity

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tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

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CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

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The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

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Transcriptional profiling of breast cancer‐associated lymphatic vessels reveals VCAM‐1 as regulator of lymphatic invasion and permeability

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Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

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NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8+ T cell responses

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Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

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Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion

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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis

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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

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Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation

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Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

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Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation

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Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils

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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

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Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

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A helminth-derived suppressor of ST2 blocks allergic responses

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OPG Production Matters Where It Happened

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An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

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Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis

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Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade

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Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves

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Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity

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The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

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Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

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The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

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Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia

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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

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Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

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Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

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Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

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Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

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The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

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Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

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Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

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A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland

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