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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

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sciencedirect.com:5037/science/article/pii/S2211124725015293
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumors

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  DOI: 10.1038/s41467-025-64862-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12606087/
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Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis

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sciencedirect.com/science/article/pii/S2211124725012975
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Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response

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1. scibot 01 Nov 2025
  
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sciencedirect.com/science/article/pii/S1074761325004650
Sep 2025
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Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

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sciencedirect.com/science/article/pii/S1074761325003693
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Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12398951/
Jul 2025
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Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

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1. scibot 31 Jul 2025
  
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Naturalized immune responses are stable over years in a colony of laboratory mice with wild-derived microbiota

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1. scibot 29 Jul 2025
  
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sciencedirect.com/science/article/pii/S1074761325003139
Jun 2025
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Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota

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1. scibot 28 Jun 2025
  
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sciencedirect.com/science/article/pii/S1074761325002456
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Gut microbiota dysbiosis induced by brain tumors modulates the efficacy of immunotherapy

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FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression

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1. scibot 17 Jun 2025
  
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An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.stem.2025.05.011
  
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sciencedirect.com/science/article/pii/S1934590925001912
May 2025
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LIMK1 variants are associated with divergent endocrinological phenotypes and altered exocytosis dynamics

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112585
  
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sciencedirect.com/science/article/pii/S2589004225008466
Apr 2025
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  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Feb 2025
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OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.immuni.2025.01.016
  
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An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101981
  
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sciencedirect.com/science/article/pii/S2666379125000540
Jan 2025
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115226
  
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sciencedirect.com/science/article/pii/S2211124724015778
Dec 2024
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IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages

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1. scibot 12 Dec 2024
  
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sciencedirect.com/science/article/pii/S2211124724013901
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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.10.044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
Jul 2024
www.cell.com www.cell.com

Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine

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  DOI: 10.1016/j.chom.2024.06.003
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00197-5
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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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1. scibot 18 Jul 2024
  
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cell.com/cancer-cell/abstract/S1535-6108(24)00226-5
Jun 2024
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Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

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ncbi.nlm.nih.gov/pmc/articles/PMC10841690/
May 2024
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Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

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1. scibot 30 May 2024
  
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Apr 2024
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CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer

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1. scibot 12 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101479
  
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Mar 2024
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Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

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  DOI: 10.1016/j.celrep.2024.113963
  
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Feb 2024
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Inflammatory dendritic cells restrain CD11b+CD4+ CTLs via CD200R in human NSCLC

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  DOI: 10.1016/j.celrep.2024.113767
  
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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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  DOI: 10.1016/j.cmet.2024.01.005
  
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Dec 2023
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Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth

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A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas

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Nov 2023
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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

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Jun 2023
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Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression

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  DOI: 10.1016/j.celrep.2023.112599
  
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sciencedirect.com/science/article/pii/S2211124723006101
Apr 2023
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Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir

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  DOI: 10.1016/j.immuni.2023.01.032
  
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sciencedirect.com/science/article/pii/S1074761323000444
Feb 2023
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Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.immuni.2023.01.005
  
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sciencedirect.com/science/article/pii/S1074761323000158
Jan 2023
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Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake

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1. scibot 31 Jan 2023
  
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  DOI: 10.1038/s41598-023-28987-1
  
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nature.com/articles/s41598-023-28987-1
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SSRN-id4265019-html.html

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1. scibot 14 Jan 2023
  
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  DOI: 10.2139/ssrn.4265019
  
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Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

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T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

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The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

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Cancer cell-derived type I interferons instruct tumor monocyte polarization

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Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment

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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

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Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo

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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade

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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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Two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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Arthritis flares mediated by tissue-resident memory T cells in the joint

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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

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IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

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Standard screening methods underreport AAV-mediated transduction and gene editing

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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

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Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

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The gut microbiota is a transmissible determinant of skeletal maturation

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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

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Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

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FOXD3 Regulates VISTA Expression in Melanoma

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

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Class-Switch Recombination Occurs Infrequently in Germinal Centers

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Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

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Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

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HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

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Untitled document

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC6298771/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_493697
  
  DOI: 10.1016/j.celrep.2019.03.029
  
  Resource: (BioLegend Cat# 100216, RRID:AB_493697)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_493697
  
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  RRID:AB_493697 RRIDCUR:Validated
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RRID:AB_493697

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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC6461402/
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 12 Jan 2020
  
  in Public
  
  RRID:AB_493697
  
  DOI: 10.1016/j.immuni.2019.04.010
  
  Resource: (BioLegend Cat# 100216, RRID:AB_493697)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_493697
  
  What is this?
  
  RRID:AB_493697 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_493697

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scibot

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sciencedirect.com/science/article/pii/S1074761319301906
Nov 2018
www.sciencedirect.com www.sciencedirect.com

CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

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1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_493697
  
  Resource used:
  
  (BioLegend Cat# 100216, RRID:AB_493697)
  
  SciCrunch record: RRID:AB_493697
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_493697
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scibot

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sciencedirect.com/science/article/pii/S1934590918300171
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_493697
  
  Curator: @chewbeccax
  
  Resource used:
  
  (BioLegend Cat# 100216, RRID:AB_493697)
  
  SciCrunch record: RRID:AB_493697
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_493697 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_493697

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scibot

URL

sciencedirect.com/science/article/pii/S1931312817302056

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