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Sep 2026
www.nature.com www.nature.com

Vibrio cholerae-synthesized tryptophan activates innate immune signaling in enteroendocrine cells via phosphorylation of the nuclear receptor ultraspiracle

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nature.com/articles/s41467-026-76080-8
Aug 2026
www.biorxiv.org www.biorxiv.org

Bx42 directs neural stem cell exit from quiescence through Prospero

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  DOI: 10.64898/2026.08.11.744202
  
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biorxiv.org/content/10.64898/2026.08.11.744202v1
Jul 2026
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Tumor-derived Ilp8 and Upd3 contribute to intestinal progenitor cells depletion during cachexia in Drosophila larvae

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  DOI: 10.1016/j.celrep.2026.117722
  
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sciencedirect.com/science/article/pii/S2211124726008004
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Orb2 RNA-binding activity promotes neural stem cell development and brain growth in Drosophila larvae

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cell.com/cell-reports/fulltext/S2211-1247(26)00758-8
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EC-isHCR: A rapid method for in situ hybridization chain reaction in diverse animal samples

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  DOI: 10.1016/j.ymeth.2026.06.007
  
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sciencedirect.com/science/article/pii/S1046202326001544
Jun 2026
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Electron transport chain complex I and mitochondrial fusion regulate ROS for differentiation in Drosophila neural stem cells

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  DOI: 10.1016/j.stemcr.2026.102951
  
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sciencedirect.com/science/article/pii/S2213671126001621
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly

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  DOI: 10.1038/s41467-026-70521-0
  
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54.241.53.176/cbb8d0fde67f74a17eee22abf8e82daaf2badce4/PMID_41820377-html.html
Apr 2026
dx.doi.org dx.doi.org

A regional regulatory axis shapes enteroendocrine cell morphology and function

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1. scibot 03 Apr 2026
  
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  DOI: 10.1083/jcb.202506084
  
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dx.doi.org/10.1083/jcb.202506084
Mar 2026
54.241.53.176 54.241.53.176

Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development

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1. scibot 19 Mar 2026
  
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  DOI: 10.1101/2023.02.03.527019
  
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54.241.53.176/bf84308bfd6a09c62e1e93379ddfffcdbd8bc386/PMID_36778312-html.html
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Toll signalling controls intestinal regeneration in Drosophila

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  DOI: 10.1242/dev.204794
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12863300/
www.nature.com www.nature.com

Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection

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  DOI: 10.1038/s41596-025-01311-z
  
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nature.com/articles/s41596-025-01311-z
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types

1
1. scibot 05 Feb 2026
  
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  DOI: 10.1038/s42003-022-04337-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9751288/
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology

1
1. scibot 10 Jan 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8546075/
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Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID

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  DOI: 10.1016/j.devcel.2025.12.003
  
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sciencedirect.com/science/article/pii/S1534580725007476
Dec 2025
54.241.53.176 54.241.53.176

A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis

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1. scibot 14 Dec 2025
  
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  DOI: 10.1073/pnas.2022583118
  
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54.241.53.176/e5deb17612a7abef786a53f2560c73bcdf0cc126/PMID_34016750-html.html
Oct 2025
54.241.53.176 54.241.53.176

PMID_32179478-html.html

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  DOI: 10.1016/j.isci.2020.100954
  
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54.241.53.176/aa182b8872edbbc89de6caef01ba097447642278/PMID_32179478-html.html
Sep 2025
elifesciences.org elifesciences.org

Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress

1
1. scibot 11 Sep 2025
  
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  DOI: 10.7554/eLife.99999
  
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elifesciences.org/articles/99999
52.53.155.43 52.53.155.43

Establishment of Drosophila Intestinal Cell Lines

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  DOI: 10.1101/2025.05.27.656384
  
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52.53.155.43/94a827de66d81d0b1517d50ab9c6681eee8a59e2/2025.05.27.656384v1.full-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Establishment of Drosophila intestinal cell lines as tools for multiomic screening and deciphering intestinal biology

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  DOI: 10.1038/s41598-025-17336-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12405456/
Aug 2025
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The Nα-acetyl-L-lysine/Loxl2/H2O2 promotes intestinal tumor growth in Drosophila and cell proliferation in human colorectal cancer

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  DOI: 10.1016/j.celrep.2025.116126
  
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sciencedirect.com/science/article/pii/S2211124725008976
Jul 2025
www.cell.com www.cell.com

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila

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cell.com/developmental-cell/fulltext/S1534-5807(25)00432-0
52.53.155.43 52.53.155.43

41467_2024_55255_MOESM1_ESM-html.html

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52.53.155.43/edc8842257cebeab3e5371bba5e385681bd125c4/41467_2024_55255_MOESM1_ESM-html.html
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation

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pmc.ncbi.nlm.nih.gov/articles/PMC6368352/
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2025.04.21.649885v1.full-html.html

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52.53.155.43/0714c863d83864fd5ae353fe6c6116b9253bace8/2025.04.21.649885v1.full-html.html
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Cell fate ratios are encoded by transcriptional dynamics in the Drosophila retina

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  DOI: 10.1016/j.cub.2025.05.037
  
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sciencedirect.com/science/article/pii/S0960982225006530
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Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

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  DOI: 10.1016/j.devcel.2025.05.009
  
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cell.com/developmental-cell/abstract/S1534-5807(25)00320-X
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Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane

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  DOI: 10.1016/j.devcel.2025.02.011
  
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cell.com/developmental-cell/fulltext/S1534-5807(25)00116-9
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

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  DOI: 10.7554/eLife.96890
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888597/
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Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila

1
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  DOI: 10.1038/s41467-025-57484-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11880416/
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Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq

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  DOI: 10.1016/j.neuron.2025.04.017
  
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sciencedirect.com/science/article/pii/S0896627325002995
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content

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  DOI: 10.1016/j.devcel.2018.08.011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6179903/
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Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

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1. scibot 16 Apr 2025
  
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  DOI: 10.7554/eLife.104723
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11981606/
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1101/2025.03.18.643858
  
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52.53.155.43/eb942f3bd7e854896f986071a5df1c98528ca14e/PDF-html.html
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A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut

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  DOI: 10.1016/j.celrep.2025.115398
  
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Deterministic genetic barcoding for multiplexed behavioral and single-cell transcriptomic studies

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The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells

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Serotonergic modulation of swallowing in a complete fly vagus nerve connectome

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Insidious chromatin change with a propensity to exhaust intestinal stem cells during aging

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Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut

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Embryonic spatio-temporal expression pattern of Folded gastrulation (Fog) suggests roles in multiple morphogenetic events and regulation by AbdA

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Jul 2024
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Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration

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Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia

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pnas.2307451120.sapp-html.html

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Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

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Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila

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scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development

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Protocol to analyze Drosophila intestinal tumor cellular heterogeneity using immunofluorescence imaging and nuclear size quantification

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Response of the microbiome–gut–brain axis in Drosophila to amino acid deficit

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Vibrio cholerae arrests intestinal epithelial proliferation through T6SS-dependent activation of the bone morphogenetic protein pathway

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Golgi-to-ER retrograde transport prevents premature differentiation of Drosophila type II neuroblasts via Notch-signal-sending daughter cells

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Chromatin state transitions in the Drosophila intestinal lineage identify principles of cell-type specification

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Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in Drosophila

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Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor

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Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells

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Disruptions in cell fate decisions and transformed enteroendocrine cells drive intestinal tumorigenesis in Drosophila

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The roles of the native cell differentiation program aberrantly recapitulated in Drosophila intestinal tumors

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Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila

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A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development

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A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Drosophila

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Jun 2023
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The septate junction component bark beetle is required for Drosophila intestinal barrier function and homeostasis

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Apr 2023
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Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

1
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Mar 2023
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A gut-secreted peptide suppresses arousability from sleep

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Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation

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Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila

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Dietary Stimuli, Intestinal Bacteria and Peptide Hormones Regulate Female Drosophila Defecation Rate

1
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Feb 2023
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Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

1
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Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

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Jan 2023
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SSRN-id4261555-html.html

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Dec 2022
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Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types

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Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size

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A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology

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Distinct p53 isoforms code for opposing transcriptional outcomes

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Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity

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Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons

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Identification of progenitor cells and their progenies in adult Drosophila midgut

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Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation

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Biotin controls intestinal stem cell mitosis and host-microbiome interactions

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Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury

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Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity

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Peripheral astral microtubules ensure asymmetric furrow positioning in neural stem cells

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Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

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An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut

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RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

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Untitled document

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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis

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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly

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The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism

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Dietary Lipids Modulate Notch Signaling and Influence Adult Intestinal Development and Metabolism in Drosophila

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Asymmetric nuclear division in neural stem cells generates sibling nuclei that differ in size, envelope composition, and chromatin organization

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Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

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A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

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Mar 2021
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Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

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Jan 2021
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Steroid‐dependent switch of OvoL/Shavenbaby controls self‐renewal versus differentiation of intestinal stem cells

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Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia

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Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila

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A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut

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The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling

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Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

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The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level

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Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair

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Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

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The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

1
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Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine

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The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

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The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

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Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation

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Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation

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Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

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Recruitment of Adult Precursor Cells Underlies Limited Repair of the Infected Larval Midgut in Drosophila

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Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

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Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

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Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content

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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

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Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

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Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

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APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

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Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila

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Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.

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Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina

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Amitosis of Polyploid Cells Regenerates Functional Stem Cells in the Drosophila Intestine

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The Super Elongation Complex Drives Neural Stem Cell Fate Commitment

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