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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.012
  
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sciencedirect.com/science/article/pii/S1534580726001590
Apr 2026
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Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.stem.2026.03.004
  
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sciencedirect.com/science/article/pii/S1934590926001141
Feb 2026
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Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116990
  
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sciencedirect.com/science/article/pii/S2211124726000689
Dec 2025
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DEC1 regulates human β cell functional maturation and circadian rhythm

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116666
  
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sciencedirect.com:5037/science/article/pii/S221112472501438X
Aug 2025
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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo

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1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.stem.2025.07.006
  
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sciencedirect.com/science/article/pii/S1934590925002632
Apr 2025
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1-s2.0-S2589004225006157-main-html.html

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112354
  
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  DOI: 10.1016/j.isci.2025.112354
  
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52.53.155.43/720905fc553fe918df9478223ae2a3887cc3a692/PDF-html.html
Feb 2025
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Expression of genes involved in thyroid hormone action in human induced pluripotent stem cells during differentiation to insulin-producing cells: Effects of iopanoic acid on differentiation

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.mce.2025.112490
  
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sciencedirect.com/science/article/pii/S0303720725000413
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111179
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11550590/
Sep 2024
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Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.09.004
  
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sciencedirect.com/science/article/pii/S0092867424010225
Aug 2024
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CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11406439/
Jun 2024
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3D Model of Mouse Embryonic Pancreas and Endocrine Compartment using Stem Cell-Derived Mesoderm and Pancreatic Progenitors

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1. scibot 07 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109959
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11144751/
May 2024
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Effective cryopreservation of human brain tissue and neural organoids

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.crmeth.2024.100777
  
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sciencedirect.com/science/article/pii/S2667237524001218
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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.010
  
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sciencedirect.com/science/article/pii/S1934590924001371
May 2023
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Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system

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1. scibot 06 May 2023
  
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  DOI: 10.1016/j.crmeth.2023.100466
  
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sciencedirect.com/science/article/pii/S2667237523000851
Jan 2023
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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

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1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.xcrm.2022.100879
  
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sciencedirect.com/science/article/pii/S2666379122004438
Dec 2022
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An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.stem.2022.12.001
  
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sciencedirect.com/science/article/pii/S1934590922004854
Aug 2022
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Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.xpro.2022.101656
  
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sciencedirect.com/science/article/pii/S2666166722005366
Mar 2022
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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1. scibot 02 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110425
  
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sciencedirect.com/science/article/pii/S2211124722001498
Dec 2021
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Differentiation of human pluripotent stem cells into pancreatic duct-like organoids

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1. scibot 09 Dec 2021
  
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  DOI: 10.1016/j.xpro.2021.100913
  
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sciencedirect.com/science/article/pii/S2666166721006195
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Transplantable human motor networks as a neuron-directed strategy for spinal cord injury

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1. scibot 16 Aug 2021
  
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  DOI: 10.1016/j.isci.2021.102827
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8333163/
www.nature.com www.nature.com

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

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1. scibot 16 Aug 2021
  
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  DOI: 10.1038/s41596-021-00560-y
  
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nature.com/articles/s41596-021-00560-y
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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

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1. scibot 05 Aug 2021
  
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  DOI: 10.1016/j.cmet.2018.04.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5989056/
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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

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  DOI: 10.1016/j.celrep.2021.109490
  
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sciencedirect.com/science/article/pii/S2211124721009177
May 2021
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A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.stem.2020.05.001
  
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sciencedirect.com/science/article/pii/S1934590920301995
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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuron.2020.06.027
  
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sciencedirect.com/science/article/pii/S0896627320304815
Apr 2021
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.stem.2021.03.005
  
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sciencedirect.com/science/article/pii/S1934590921001119
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Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.scr.2021.102371
  
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sciencedirect.com/science/article/pii/S1873506121002178
Sep 2020
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SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107687
  
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sciencedirect.com/science/article/pii/S2211124720306409
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A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates

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  DOI: 10.1016/j.celrep.2020.107862
  
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sciencedirect.com/science/article/pii/S2211124720308433
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

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1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.xcrm.2020.100097
  
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pubmed.ncbi.nlm.nih.gov/33205073/
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Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107623
  
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sciencedirect.com/science/article/pii/S2211124720305763
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The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats

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1. scibot 09 Sep 2020
  
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  DOI: 10.1152/ajpendo.00385.2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6732465/
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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

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1. scibot 06 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107894
  
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sciencedirect.com/science/article/pii/S2211124720308755
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Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108067
  
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sciencedirect.com/science/article/pii/S2211124720310524
Jan 2020
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FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.06.034
  
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Circadian Entrainment Triggers Maturation of Human In Vitro Islets

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  DOI: 10.1016/j.stem.2019.11.011
  
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Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells

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  DOI: 10.1016/j.cmet.2019.12.009
  
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Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

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  DOI: 10.1016/j.celrep.2019.04.083
  
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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

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Untitled document

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Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development

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