Hypothesis

33 Matching Annotations

Jun 2026
www.nature.com www.nature.com

DNA replication stress and translational repression converge to drive CDK1- and caspase-dependent apoptosis in Ewing sarcoma

1
1. scibot 16 Jun 2026
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s41388-026-03845-2
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

nature.com/articles/s41388-026-03845-2
www.sciencedirect.com www.sciencedirect.com

The WEE1 inhibitor azenosertib broadly enhances efficacy of antibody-drug conjugates with topoisomerase I and microtubule inhibitor payloads

1
1. scibot 16 Jun 2026
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.isci.2026.116390
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2589004226017657
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation

1
1. scibot 19 Dec 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.isci.2025.114057
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12702247/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Coiled-coil interactions drive the ectopic condensation of overexpressed MAD1 to promote mitotic slippage in cancer cells

1
1. scibot 15 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.isci.2025.113638
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12547712/
54.241.53.176 54.241.53.176

hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html

3
1. scibot 08 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s44320-025-00141-1
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
2. scibot 07 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s44320-025-00141-1
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
3. scibot 07 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s44320-025-00141-1
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

54.241.53.176/9c78a41645fcc9eb1ef3871f95e64fd70faf70c8/hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html
www.embopress.org www.embopress.org

Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

1
1. scibot 07 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s44320-025-00141-1
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

embopress.org/doi/10.1038/s44320-025-00141-1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma

1
1. scibot 07 Oct 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.isci.2025.113456
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12496224/
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Beauvericin disrupts G2/M transition and induces meiotic arrest during mouse oocyte maturation

1
1. scibot 20 Aug 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.reprotox.2025.109032
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0890623825002035
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

1
1. scibot 02 Jul 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.xcrm.2025.102211
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12281435/
May 2025
www.sciencedirect.com www.sciencedirect.com

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

1
1. scibot 22 May 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2025.115733
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124725005042
Mar 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death

2
1. scibot 06 Mar 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1111/bph.17464
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
2. scibot 06 Mar 2025
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1111/bph.17464
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

1
1. scibot 21 Nov 2024
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1038/s44318-024-00240-z
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 21 Aug 2024
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
Jul 2024
www.science.org www.science.org

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

1
1. scibot 18 Jul 2024
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1126/science.adk0775
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

science.org/doi/10.1126/science.adk0775
May 2024
www.sciencedirect.com www.sciencedirect.com

Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.xcrm.2024.101578
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666379124002702
May 2023
www.sciencedirect.com www.sciencedirect.com

p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

1
1. scibot 13 May 2023
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2023.112479
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124723004904
www.sciencedirect.com www.sciencedirect.com

KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

1
1. scibot 05 May 2023
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2022.111077
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722008750
Jan 2023
aacrjournals.org aacrjournals.org

ER-001259851-000, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs

1
1. scibot 14 Jan 2023
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1158/1535-7163.MCT-21-0879
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

aacrjournals.org/mct/article/22/1/12/711996/ER-851-a-Novel-Selective-Inhibitor-of-AXL
May 2022
www.sciencedirect.com www.sciencedirect.com

WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

1
1. scibot 19 May 2022
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2022.110814
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S221112472200585X
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

1
1. scibot 09 Mar 2022
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2022.110468
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722002017
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Compartmentalized control of Cdk1 drives mitotic spindle assembly

1
1. scibot 26 Jan 2022
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.celrep.2022.110305
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722000171
Oct 2021
www.sciencedirect.com www.sciencedirect.com

A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

1
1. scibot 19 Oct 2021
  
  in Public
  
  4539
  
  DOI: 10.1016/j.cub.2021.09.050
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_560953
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0960982221012902
Aug 2021
europepmc.org europepmc.org

Untitled document

1
1. scibot 06 Aug 2021
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.7554/eLife.40856
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

europepmc.org/articles/PMC6292694/
Jul 2021
www.sciencedirect.com www.sciencedirect.com

Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

1
1. scibot 01 Jul 2021
  
  in Public
  
  4539
  
  DOI: 10.1016/j.biocel.2021.106028
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_560953
Visit annotations in context

Tags

RRIDCUR:Missing

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1357272521001060
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.7554/eLife.48943
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_560953

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6887120/
www.sciencedirect.com www.sciencedirect.com

Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.ccell.2019.05.001
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_560953

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610819302247
www.sciencedirect.com www.sciencedirect.com

Development and Characterization of a Wee1 Kinase Degrader

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.1016/j.chembiol.2019.10.013
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_560953

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2451945619303587
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_560953
  
  DOI: 10.7554/eLife.40856
  
  Resource: (Cell Signaling Technology Cat# 4539, RRID:AB_560953)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_560953
  
  What is this?
  
  RRID:AB_560953 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_560953

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6292694/
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_560953
  
  Resource used:
  
  (Cell Signaling Technology Cat# 4539S, RRID:AB_560953)
  
  SciCrunch record: RRID:AB_560953
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124718314116
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Systematic Functional Annotation of Somatic Mutations in Cancer

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_560953
  
  Resource used:
  
  (Cell Signaling Technology Cat# 4539S, RRID:AB_560953)
  
  SciCrunch record: RRID:AB_560953
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_560953
Visit annotations in context

Tags

RRID:AB_560953

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC5926201/