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A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

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1. scibot 24 Sep 2026
  
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  DOI: 10.1126/sciadv.aec0722
  
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science.org/doi/10.1126/sciadv.aec0722
Jul 2025
www.biorxiv.org www.biorxiv.org

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.22.666069
  
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biorxiv.org/content/10.1101/2025.07.22.666069v1
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

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1. scibot 08 Mar 2025
  
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  DOI: 10.1038/s41467-025-57229-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882782/
Jan 2025
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The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2025.101929
  
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sciencedirect.com/science/article/pii/S2666379125000023
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Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway

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1. scibot 16 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0471
  
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2. scibot 16 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695814/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model

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1. scibot 02 Oct 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11425777/
Jul 2024
www.cell.com www.cell.com

Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114337
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00665-X
Apr 2024
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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.ccell.2024.04.004
  
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sciencedirect.com/science/article/pii/S1535610824001284
Feb 2024
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

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1. scibot 15 Feb 2024
  
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  DOI: 10.1126/sciadv.adk1835
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10866549/
Jul 2023
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Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates

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1. scibot 04 Jul 2023
  
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  DOI: 10.7554/eLife.78695
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10313321/
Dec 2022
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p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111810
  
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sciencedirect.com/science/article/pii/S2211124722016989
May 2022
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Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

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1. scibot 18 May 2022
  
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  DOI: 10.1016/j.cmet.2022.04.012
  
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sciencedirect.com/science/article/pii/S1550413122001826
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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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1. scibot 05 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.010
  
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sciencedirect.com/science/article/pii/S1097276522003215
Apr 2022
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Functional elements of the cis-regulatory lincRNA-p21

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1. scibot 20 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110687
  
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sciencedirect.com/science/article/pii/S2211124722004454
Dec 2021
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Dynamic stem cell selection safeguards the genomic integrity of the epidermis

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1. scibot 21 Dec 2021
  
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  DOI: 10.1016/j.devcel.2021.11.018
  
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sciencedirect.com/science/article/pii/S1534580721009424
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Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

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1. scibot 02 Dec 2021
  
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  DOI: 10.1016/j.isci.2021.103376
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8605199/
Aug 2021
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Untitled document

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1. scibot 10 Aug 2021
  
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  DOI: 10.1016/j.celrep.2018.12.071
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6334229/
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Untitled document

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1. scibot 10 Aug 2021
  
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  DOI: 10.1016/j.immuni.2018.09.013
  
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sciencedirect.com/science/article/pii/S107476131830428X
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Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.stem.2018.10.011
  
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sciencedirect.com/science/article/pii/S1934590918304922
May 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2020.10.022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7654708/
Sep 2020
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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.03.062
  
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sciencedirect.com/science/article/pii/S0092867420303950
Jan 2020
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The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.devcel.2019.05.015
  
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sciencedirect.com/science/article/pii/S1534580719303879
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Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.devcel.2019.06.012
  
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sciencedirect.com/science/article/pii/S1534580719305301
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Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.11.058
  
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sciencedirect.com/science/article/pii/S2211124719315499
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Untitled document

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sciencedirect.com/science/article/pii/S2211124718320163
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Untitled document

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  DOI: 10.1016/j.cmet.2019.03.001
  
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sciencedirect.com/science/article/pii/S1550413119301299
Nov 2018
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The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2211124718315390
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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1934590918304375
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818302174
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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

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sciencedirect.com/science/article/pii/S1535610818300023
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Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

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sciencedirect.com/science/article/pii/S153561081730507X
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Conservation and Divergence of p53 Oscillation Dynamics across Species

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sciencedirect.com/science/article/pii/S2405471217304337
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H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S153561081730418X
Nov 2017
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A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

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1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
  Resource used:
  
  (Leica Microsystems Cat# NCL-p53-CM5p, RRID:AB_563933)
  
  SciCrunch record: RRID:AB_563933
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_563933 RRIDCUR:Validated
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Tags

RRIDCUR:Validated

RRID:AB_563933

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610817304117