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Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

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1. scibot 06 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.006
  
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sciencedirect.com/science/article/pii/S1074761326002578
Jul 2026
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Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

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1. scibot 05 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.006
  
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Intratumoral Regulatory T cell Ablation Mediates Tumor Control Systemically without Autoimmunity

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1. scibot 03 Jul 2026
  
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  RRID:AB_572017
  
  DOI: 10.1158/0008-5472.CAN-25-3473
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13321386/
Jun 2026
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Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.immuni.2026.05.017
  
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sciencedirect.com/science/article/pii/S1074761326002281
Mar 2026
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NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.immuni.2026.02.016
  
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sciencedirect.com/science/article/pii/S1074761326000865
Feb 2026
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Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC

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1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2026.102633
  
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sciencedirect.com/science/article/pii/S2666379126000509
Jul 2025
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PLT012, a humanized CD36-blocking antibody, is effective for unleashing anti-tumor immunity against liver cancer and liver metastasis

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1. scibot 30 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1409
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617665/
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
Jun 2025
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Immune imprinting blunts omicron pathogenicity fluctuations and highlights the essential role of cellular immunity in SARS-CoV-2 infection

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1. scibot 05 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115784
  
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sciencedirect.com/science/article/pii/S2211124725005558
May 2025
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52.53.155.43/449eeec941982dcbbbd18cfe95d7f2b03d57e236/PDF-html.html
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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
Apr 2025
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.004
  
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sciencedirect.com/science/article/pii/S1074761325001232
Mar 2025
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Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115388
  
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sciencedirect.com/science/article/pii/S2211124725001597
Feb 2025
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A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

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1. scibot 14 Feb 2025
  
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  RRID:AB_572017
  
  DOI: 10.1016/j.celrep.2025.115301
  
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sciencedirect.com/science/article/pii/S2211124725000725
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Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination

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1. scibot 13 Feb 2025
  
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  RRID:AB_572017
  
  DOI: 10.1016/j.celrep.2025.115295
  
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sciencedirect.com/science/article/pii/S221112472500066X
Jan 2025
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression

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1. scibot 23 Jan 2025
  
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  RRID:AB_572017
  
  DOI: 10.1016/j.celrep.2024.115226
  
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sciencedirect.com/science/article/pii/S2211124724015778
Dec 2024
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Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.031
  
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sciencedirect.com/science/article/pii/S0092867424013473
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION

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1. scibot 18 Sep 2024
  
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  AB_572017
  
  DOI: 10.1101/2024.08.23.609450
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11382997/
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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.029
  
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sciencedirect.com/science/article/pii/S0092867424009565
Aug 2024
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Epithelial organoid supports resident memory CD8 T cell differentiation

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114621
  
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sciencedirect.com/science/article/pii/S2211124724009719
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Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114632
  
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sciencedirect.com/science/article/pii/S2211124724009823
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.018
  
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sciencedirect.com/science/article/pii/S0092867424007785
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.016
  
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sciencedirect.com/science/article/pii/S0092867424007761
Jul 2024
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Lack of canonical thyroid hormone receptor α signaling changes regulatory T cell phenotype in female mice

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1. scibot 25 Jul 2024
  
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  AB_572017
  
  DOI: 10.1016/j.isci.2024.110547
  
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52.53.155.43/ec8bf473a95e0f0a14821b5e61884b766010f004/1-s2.0-S2589004224017723-main-html.html
May 2024
www.cell.com www.cell.com

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.026
  
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cell.com/immunity/fulltext/S1074-7613(24)00231-0
Jan 2024
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

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1. scibot 12 Jan 2024
  
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  RRID:AB_572017
  
  DOI: 10.1016/j.ccell.2023.12.013
  
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sciencedirect.com/science/article/pii/S1535610823004415
Dec 2023
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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.immuni.2023.11.005
  
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sciencedirect.com/science/article/pii/S1074761323004879
Oct 2023
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Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113224
  
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sciencedirect.com/science/article/pii/S2211124723012366
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glucose Oxidation-Dependent Survival of Activated B Cells Provides a Putative Novel Therapeutic Target for Lupus Treatment

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107487
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10448027/
Jun 2023
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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  DOI: 10.1016/j.celrep.2023.112693
  
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sciencedirect.com/science/article/pii/S2211124723007040
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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.immuni.2023.05.008
  
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sciencedirect.com/science/article/pii/S107476132300225X
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DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.05.028
  
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sciencedirect.com/science/article/pii/S0092867423005809
Mar 2023
europepmc.org europepmc.org

Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma

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1. scibot 25 Mar 2023
  
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  DOI: 10.1016/j.ccell.2023.03.004
  
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europepmc.org/article/med/36963400
Jan 2023
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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

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1. scibot 12 Jan 2023
  
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  DOI: 10.1016/j.immuni.2022.12.006
  
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sciencedirect.com/science/article/pii/S1074761322006422
Dec 2022
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Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111783
  
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sciencedirect.com/science/article/pii/S2211124722016710
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection

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1. scibot 04 Nov 2022
  
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  DOI: 10.7554/eLife.80079
  
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PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

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PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

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ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes

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Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells

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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory

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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

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Follicular T Cells Optimize the Germinal Center Response to SARS-CoV-2 Protein Vaccination in Mice

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ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

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Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure

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Untitled document

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IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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Natural Tr1-like cells do not confer long-term tolerogenic memory

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Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

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Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection

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Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

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TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

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SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

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B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer’s Patches

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Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

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Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

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Foxo3 Promotes the Differentiation and Function of Follicular Helper T Cells

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CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

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IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression

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  DOI: 10.1016/j.celrep.2019.10.069
  
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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

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  DOI: 10.1016/j.cell.2019.07.019
  
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  DOI: 10.1016/j.immuni.2018.12.016
  
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  DOI: 10.1016/j.immuni.2018.12.021
  
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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

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Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection - ScienceDirect

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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

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