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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Sep 2025
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Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116266
  
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sciencedirect.com/science/article/pii/S221112472501037X
May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

1
1. scibot 31 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115766
  
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sciencedirect.com/science/article/pii/S2211124725005376
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Regulation of translation elongation and integrated stress response in heat-shocked neurons

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115639
  
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sciencedirect.com/science/article/pii/S2211124725004103
Apr 2025
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Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.chom.2025.03.008
  
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sciencedirect.com/science/article/pii/S1931312825000915
Nov 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling-induced dietary peptide uptake via PEPT-1

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1. scibot 08 Nov 2024
  
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  DOI: 10.1038/s44318-024-00234-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11535032/
Jun 2024
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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.017
  
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sciencedirect.com/science/article/pii/S0092867424005269
May 2024
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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

1
1. scibot 17 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.014
  
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sciencedirect.com/science/article/pii/S1097276524003290
Apr 2024
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The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila

1
1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.04.003
  
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sciencedirect.com/science/article/pii/S1534580724002284
link.springer.com link.springer.com

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

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1. scibot 24 Apr 2024
  
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  AB_612093
  
  DOI: 10.1038/s41594-024-01294-7
  
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link.springer.com/article/10.1038/s41594-024-01294-7
Feb 2024
www.biorxiv.org www.biorxiv.org

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

1
1. scibot 15 Feb 2024
  
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  AB_612093
  
  DOI: 10.1101/2023.12.20.572718
  
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biorxiv.org/content/10.1101/2023.12.20.572718v1
Jan 2024
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The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo

1
1. scibot 11 Jan 2024
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2023.113651
  
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sciencedirect.com/science/article/pii/S2211124723016625
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ubiquiton—An inducible, linkage-specific polyubiquitylation tool

1
1. scibot 16 Dec 2023
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.molcel.2023.11.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
Jun 2023
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Identification of XAF1 as an endogenous AKT inhibitor

1
1. scibot 29 Jun 2023
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2023.112690
  
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sciencedirect.com/science/article/pii/S2211124723007015
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

1
1. scibot 28 Jun 2023
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2023.112693
  
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sciencedirect.com/science/article/pii/S2211124723007040
Feb 2023
www.nature.com www.nature.com

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

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1. scibot 04 Feb 2023
  
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  RRID:AB_612093
  
  DOI: 10.1038/s41467-023-36058-2
  
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nature.com/articles/s41467-023-36058-2
Nov 2022
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Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites

1
1. scibot 16 Nov 2022
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2022.111658
  
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sciencedirect.com/science/article/pii/S2211124722015297
Mar 2022
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Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass

1
1. scibot 09 Mar 2022
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.molcel.2022.02.016
  
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sciencedirect.com/science/article/pii/S1097276522001393
Jan 2022
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Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

1
1. scibot 06 Jan 2022
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.isci.2021.103650
  
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sciencedirect.com/science/article/pii/S2589004221016205
Oct 2021
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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

1
1. scibot 21 Oct 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2021.109870
  
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sciencedirect.com/science/article/pii/S2211124721013371
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 10 Aug 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2018.12.027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6316133/
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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

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1. scibot 07 Aug 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.cell.2018.11.024
  
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sciencedirect.com/science/article/pii/S0092867418315162
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Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.1016/j.molcel.2018.11.015
  
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sciencedirect.com/science/article/pii/S1097276518309857
europepmc.org europepmc.org

Untitled document

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1. scibot 01 Aug 2021
  
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  DOI: 10.7554/eLife.38771
  
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europepmc.org/articles/PMC6037479/
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 30 Jul 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.molcel.2018.08.020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6202423/
rupress.org rupress.org

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

1
1. scibot 23 Jul 2021
  
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  04-263
  
  DOI: 10.1083/jcb.202006043
  
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  RRIDCUR:Missing RRID:AB_612093
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rupress.org/jcb/article/220/6/e202006043/211984/Parkin-independent-mitophagy-via-Drp1-mediated
Jun 2021
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Mammalian cells use the autophagy process to restrict avian influenza virus replication

1
1. scibot 09 Jun 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2021.109213
  
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sciencedirect.com/science/article/pii/S2211124721005635
Mar 2021
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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

1
1. scibot 22 Mar 2021
  
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  RRID:AB_61093
  
  DOI: 10.1016/j.molcel.2021.01.009
  
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  RRIDCUR:Unresolved RRIDCUR:Incorrect RRID:AB_612093
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sciencedirect.com/science/article/pii/S1097276521000095
Jan 2021
www.sciencedirect.com www.sciencedirect.com

Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

1
1. scibot 27 Jan 2021
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2020.108680
  
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  RRIDCUR:Validated RRID:AB_612093
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sciencedirect.com/science/article/pii/S2211124720316697
Oct 2020
currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Proximity Ligation Assay for Detecting Protein‐Protein Interactions and Protein Modifications in Cells and Tissues in Situ

1
1. scibot 16 Oct 2020
  
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  RRID:AB_612093
  
  DOI: 10.1002/cpcb.115
  
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  RRID:AB_612093 RRIDCUR:Validated
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currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpcb.115
Sep 2020
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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

1
1. scibot 11 Sep 2020
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.stem.2019.12.006
  
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  RRIDCUR:Validated RRID:AB_612093
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sciencedirect.com/science/article/pii/S1934590919305247
Jan 2020
www.sciencedirect.com www.sciencedirect.com

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

1
1. scibot 13 Jan 2020
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.chembiol.2019.11.004
  
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  RRID:AB_612093 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945619303629
elifesciences.org elifesciences.org

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

1
1. scibot 13 Jan 2020
  
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  RRID:AB_612093
  
  DOI: 10.7554/eLife.44502
  
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  RRID:AB_612093 RRIDCUR:Validated
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elifesciences.org/articles/44502
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ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response

1
1. scibot 13 Jan 2020
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2019.09.008
  
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  RRID:AB_612093 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719311854
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_612093
  
  DOI: 10.1016/j.celrep.2018.12.027
  
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  Curator: @evieth
  
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  RRID:AB_612093 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718319570
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Untitled document

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1. scibot 05 Nov 2018
  
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  RRID:AB_612093
  
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  (Millipore Cat# 04-263, RRID:AB_612093)
  
  SciCrunch record: RRID:AB_612093
  
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Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling

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USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels

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Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.

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Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

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Nov 2017
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Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

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Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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