93 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle
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    1. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S1097276524002223
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.004

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    sciencedirect.com/science/article/pii/S1934590924000857
  4. Mar 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
    1
    1. scibot 31 Mar 2024
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      DOI: 10.1038/s42003-024-06071-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10978903/
  6. Feb 2024
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    Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons
    2
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.isci.2024.109166

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      DOI: 10.1016/j.isci.2024.109166

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    sciencedirect.com/science/article/pii/S2589004224003870
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    hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113769

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    sciencedirect.com/science/article/pii/S2211124724000974
  9. jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com
    Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1186/s12974-024-03039-1

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    2. scibot 15 Feb 2024
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    jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03039-1
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    Mouse oocytes sequester aggregated proteins in degradative super-organelles
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.031

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    sciencedirect.com/science/article/pii/S0092867424000680
  11. www.sciencedirect.com www.sciencedirect.com
    Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.022

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    sciencedirect.com/science/article/pii/S0896627324000485
  12. Jan 2024
  13. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1126/sciadv.ade1282

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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113662

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857847/
  15. Dec 2023
  16. www.sciencedirect.com www.sciencedirect.com
    Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113509

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    sciencedirect.com/science/article/pii/S2211124723015218
  17. Nov 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Targeted perturbation of signaling-driven condensates
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.023

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    sciencedirect.com/science/article/pii/S1097276523008602
  19. Sep 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.jbc.2023.105272

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    sciencedirect.com/science/article/pii/S0021925823023001
  21. Aug 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients
    1
    1. scibot 26 Aug 2023
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      DOI: 10.3389/fnmol.2023.1243277

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    ncbi.nlm.nih.gov/pmc/articles/PMC10445132/
  23. www.sciencedirect.com www.sciencedirect.com
    Tuning Hsp104 specificity to selectively detoxify α-synuclein
    1
    1. scibot 25 Aug 2023
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    sciencedirect.com/science/article/abs/pii/S1097276523006044
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    Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal
    1
    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112998

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    sciencedirect.com/science/article/pii/S2211124723010094
  25. 52.53.155.43 52.53.155.43
    Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1093/brain/awad264

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    52.53.155.43/5178e3b5a29ba09ab2106f8993d42d5e0411ae62/awad264 (1)-html.html
  26. Jul 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112841

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    sciencedirect.com/science/article/pii/S2211124723008525
  28. Jun 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence
    1
    1. scibot 24 Jun 2023
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      DOI: 10.12688/f1000research.131852.2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10285334/
  30. May 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.isci.2023.106645

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    sciencedirect.com/science/article/pii/S2589004223007228
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    Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.celrep.2022.111086

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    sciencedirect.com/science/article/pii/S2211124722008889
  33. Apr 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 27 Apr 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  35. Mar 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ILF3 prion-like domain regulates gene expression and fear memory under chronic stress
    1
    1. scibot 09 Mar 2023
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      DOI: 10.1016/j.isci.2023.106229

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    ncbi.nlm.nih.gov/pmc/articles/PMC9982275/
  37. Feb 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
    1
    1. scibot 24 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112134

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    sciencedirect.com/science/article/pii/S2211124723001456
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    PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.005

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    SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.stem.2023.01.005

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    sciencedirect.com/science/article/pii/S193459092300005X
  41. Oct 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111508

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    sciencedirect.com/science/article/pii/S2211124722013584
  43. Aug 2022
  44. www.embopress.org www.embopress.org
    Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons
    1
    1. scibot 26 Aug 2022
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      DOI: 10.15252/embj.2021110486

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    embopress.org/doi/10.15252/embj.2021110486
  45. May 2022
  46. link.springer.com link.springer.com
    Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment
    1
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      DOI: 10.1186/s40478-022-01352-5

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    link.springer.com/article/10.1186/s40478-022-01352-5
  47. Mar 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models
    1
    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.devcel.2022.02.022

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
    1
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      DOI: 10.1038/s41586-022-04424-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8891019/
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    Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases
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      DOI: 10.1016/j.cell.2022.02.026

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    sciencedirect.com/science/article/pii/S0092867422002598
  51. Dec 2021
  52. www.sciencedirect.com www.sciencedirect.com
    Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS
    1
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    sciencedirect.com/science/article/pii/S2589004221014759
  53. www.sciencedirect.com www.sciencedirect.com
    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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      DOI: 10.1016/j.cmet.2021.11.011

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    sciencedirect.com/science/article/pii/S1550413121005398
  54. Aug 2021
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
    1
    1. scibot 16 Aug 2021
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      DOI: 10.1186/s13024-021-00470-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8353748/
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    TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.cell.2021.07.018

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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability
    1
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      DOI: 10.1523/JNEUROSCI.2282-17.2018

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    ncbi.nlm.nih.gov/pmc/articles/PMC6705897/
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    Untitled document
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      DOI: 10.1016/j.cell.2018.10.057

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  59. www.sciencedirect.com www.sciencedirect.com
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  60. Jul 2021
  61. www.nature.com www.nature.com
    Rapid in vitro quantification of TDP-43 and FUS mislocalisation for screening of gene variants implicated in frontotemporal dementia and amyotrophic lateral sclerosis
    1
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    6
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  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phosphorylation of Trans-active response DNA binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing
    1
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  65. journals.plos.org journals.plos.org
    DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro
    2
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  66. www.sciencedirect.com www.sciencedirect.com
    Neuronal VCP loss of function recapitulates FTLD-TDP pathology
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
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  68. Jun 2021
  69. elifesciences.org elifesciences.org
    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology
    1
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  70. May 2021
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    UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
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    Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
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  73. www.sciencedirect.com www.sciencedirect.com
    G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
    1
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  74. www.sciencedirect.com www.sciencedirect.com
    Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
    1
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  75. Mar 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells
    1
    1. scibot 17 Mar 2021
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      DOI: 10.7554/eLife.64456

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  77. Jan 2021
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic genetic variation revealed in diverse Hsp104 homologs
    1
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  79. Dec 2020
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
    1
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  81. www.sciencedirect.com www.sciencedirect.com
    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
    1
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  82. Nov 2020
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Amyotrophic lateral sclerosis associated mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex
    1
    1. scibot 19 Nov 2020
      rabbit polyclonal α‐TDP‐43

      DOI: 10.1111/jnc.15214

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  84. Sep 2020
  85. www.sciencedirect.com www.sciencedirect.com
    Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
    1
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      DOI: 10.1016/j.neuron.2020.04.011

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  86. link.springer.com link.springer.com
    Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network
    1
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      DOI: 10.1007/s11064-020-03019-w

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  87. www.sciencedirect.com www.sciencedirect.com
    Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
    1
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      DOI: 10.1016/j.celrep.2020.108050

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  88. jcs.biologists.org jcs.biologists.org
    TDP-43 a protein central to amyotrophic lateral sclerosis is destabilized by Tankyrase-1/2
    3
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      RRID: AB_615042

      DOI: 10.1242/jcs.245811

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      DOI: 10.1242/jcs.245811

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      DOI: 10.1242/jcs.245811

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  89. www.sciencedirect.com www.sciencedirect.com
    An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
    1
    1. scibot 03 Sep 2020
      rabbit anti-TDP-43

      DOI: 10.1016/j.nbd.2020.105050

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    sciencedirect.com/science/article/pii/S0969996120303259
  90. Jan 2020
  91. www.sciencedirect.com www.sciencedirect.com
    Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
    1
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  92. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.04.003

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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
    1
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      RRID:AB_615042

      DOI: 10.7554/eLife.40811

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  94. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
    1
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      RRID:AB_615042

      DOI: 10.1016/j.neuron.2019.02.038

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    Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
    1
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      RRID:AB_615042

      DOI: 10.1016/j.molcel.2019.03.041

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  96. www.sciencedirect.com www.sciencedirect.com
    Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS
    1
    1. scibot 12 Jan 2020
      RRID:AB_615042

      DOI: 10.1016/j.celrep.2018.12.045

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  97. link.springer.com link.springer.com
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      RRID:AB_615042

      DOI: 10.1007/s00401-018-1942-8

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  98. Nov 2018
  99. www.sciencedirect.com www.sciencedirect.com
    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
    1
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    Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
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    Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
    1
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      Curator: @Jmenke

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  102. www.jneurosci.org www.jneurosci.org
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    jneurosci.org/content/38/10/2615
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP‐43 tissue pathology
    1
    1. scibot 05 Nov 2018
      RRID:AB_615042

      Curator: @evieth

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/cne.24397/full
  104. Nov 2017
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread
    1
    1. neurohugo 12 Nov 2017
      Proteintech Group Inc. no. 10782-2-AP, rabbit, IgG, polyclonal;

      Proteintech Group Cat# 10782-2-AP Lot# RRID:AB_615042

      RRID:AB_615042
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    ncbi.nlm.nih.gov/pmc/articles/PMC4981144/
  106. www.sciencedirect.com www.sciencedirect.com
    TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
    1
    1. scibot 08 Nov 2017
      RRID:AB_615042

      Curator: @Jmenke

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      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627317306475
  107. www.sciencedirect.com www.sciencedirect.com
    TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
    1
    1. scibot 08 Nov 2017
      AB_615042

      Curator: @chewbeccax

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627317304750
  108. www.sciencedirect.com www.sciencedirect.com
    Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31
    1
    1. scibot 08 Nov 2017
      AB_615042

      Curator: @Zeljana_Babic

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S089662731730154X
  109. www.sciencedirect.com www.sciencedirect.com
    A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
    1
    1. scibot 08 Nov 2017
      TDP-43 antibody

      Curator: @kaitlinsung

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S2405471216303702
  110. www.sciencedirect.com www.sciencedirect.com
    C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
    1
    1. scibot 08 Nov 2017
      AB_615042

      Curator: @gabimpine

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867416313836
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    2
    1. scibot 08 Nov 2017
      AB_615042

      Curator: @jcabotaj

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042
    2. scibot 08 Nov 2017
      AB_615042

      Resource used:

      (Proteintech Group Cat# 10782-2-AP, RRID:AB_615042)

      SciCrunch record: RRID:AB_615042

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_615042
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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/