301 Matching Annotations
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    Bioluminescence assay of lysine deacylase sirtuin activity
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    sciencedirect.com/science/article/pii/S2451945624004410
  3. Nov 2024
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females
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  6. Oct 2024
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    Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis
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    Combination of JAKi and HDACi Exerts Antiangiogenic Potential in Cutaneous T-Cell Lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11430229/
  9. Sep 2024
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    Saturation mutagenesis-reinforced functional assays for disease-related genes
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    sciencedirect.com/science/article/pii/S0092867424009760
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    Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations
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    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
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    LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses
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    The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix
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    Hesperetin but not ellagic acid increases myosin heavy chain expression and cell fusion in C2C12 myoblasts in the presence of oxidative stress
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  16. Aug 2024
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    Serine and glycine physiology reversibly modulate retinal and peripheral nerve function
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    Structural requirements for activity of Mind bomb1 in Notch signaling
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    The FXR1 network acts as a signaling scaffold for actomyosin remodeling
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    SMYD5 is a regulator of the mild hypothermia response
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    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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  23. Jul 2024
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    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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    The extracellular matrix integrates mitochondrial homeostasis
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    CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection
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    Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure
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    Hippocampal astrocytes induce sex-dimorphic effects on memory
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    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
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    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    RDH12 allows cone photoreceptors to regenerate opsin visual pigments from a chromophore precursor to escape competition with rods
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  33. Jun 2024
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    KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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  36. May 2024
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    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
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    Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
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    Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
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    Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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  42. Apr 2024
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    The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila
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    The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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    Chromatin context-dependent regulation and epigenetic manipulation of prime editing
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    XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
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    Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
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    Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
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  51. Mar 2024
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    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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    Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research
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  54. Feb 2024
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
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    Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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  59. Jan 2024
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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  61. Dec 2023
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    Subcytoplasmic location of translation controls protein output
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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  68. Oct 2023
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    Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin
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    The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice
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  72. Sep 2023
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    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
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    A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
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    Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR
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  77. Aug 2023
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    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    Cooperative and competitive regulation of the astrocytic transcriptome by neurons and endothelial cells: Impact on astrocyte maturation
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  82. Jul 2023
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    AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice
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    Sex-Dependent Effects of Chronic Restraint Stress on Mood-Related Behaviours and Neurochemistry in Mice
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    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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  89. May 2023
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    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
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    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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    Thyroid Stem Cell Speciation – A Major Role for PKC
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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  95. Apr 2023
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    A tubule-sheet continuum model for the mechanism of nuclear envelope assembly
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    NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons
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    MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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  101. Mar 2023
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium
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    Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
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    Angiotensin Deficient FVB/N Mice are Normotensive
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  108. Feb 2023
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
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    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  113. Jan 2023
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Bump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells
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    Protrusion growth driven by myosin-generated force
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    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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  120. Dec 2022
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  122. Nov 2022
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    Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites
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    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
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    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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  126. Oct 2022
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    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    Selenium modulates cancer cell response to pharmacologic ascorbate
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    Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein
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    A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo
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    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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  133. Sep 2022
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    Confined migration induces heterochromatin formation and alters chromatin accessibility
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    Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment
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  138. Aug 2022
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
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    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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  142. Jul 2022
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    A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
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    Context-dependent regulation of ferroptosis sensitivity
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  145. Jun 2022
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Identification of metabolic pathways underlying FGF1 and CHIR99021-mediated cardioprotection
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  150. May 2022
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    Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
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  152. www.sciencedirect.com www.sciencedirect.com
    Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
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  155. Apr 2022
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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    Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock
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  159. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3
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    Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases
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    AP-4-mediated axonal transport controls endocannabinoid production in neurons
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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    Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
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    Combination of Resminostat with Ruxolitinib Exerts Antitumor Effects in the Chick Embryo Chorioallantoic Membrane Model for Cutaneous T Cell Lymphoma
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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  168. Feb 2022
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    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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    miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence
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  179. Dec 2021
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  184. Nov 2021
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  186. Oct 2021
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  188. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork
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  191. Sep 2021
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  194. Aug 2021
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    Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
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  196. www.sciencedirect.com www.sciencedirect.com
    TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
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      DOI: 10.1016/j.cell.2021.07.018

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    FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner
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      DOI: 10.1016/j.molcel.2021.07.010

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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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    Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Contribute to Neuronal Cell Loss in an Animal Model of Multiple Sclerosis
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  206. Jul 2021
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    Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
    2
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      Donkey anti-Rabbit pig IRDye 680RD

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      Donkey anti-Rabbit pig IRDye 800CW

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  208. academic.oup.com academic.oup.com
    Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice
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  209. wellcomeopenresearch.org wellcomeopenresearch.org
    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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      IRDye 800CW Donkey anti-Rabbit IgG

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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
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    RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway
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      IRDye 800CW Donkey anti-rabbit

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    sciencedirect.com/science/article/pii/S1097276518310323
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      DOI: 10.1016/j.cell.2018.10.007

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    sciencedirect.com/science/article/pii/S0092867418313151
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    The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30
    1
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      RRID:926-32213

      DOI: 10.1016/j.molcel.2017.11.034

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  215. www.sciencedirect.com www.sciencedirect.com
    Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2
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      AB_621848

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  216. academic.oup.com academic.oup.com
    Dysregulation of GABAA Receptor-Mediated Neurotransmission during the Auditory Cortex Critical Period in the Fragile X Syndrome Mouse Model
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  217. www.sciencedirect.com www.sciencedirect.com
    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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    sciencedirect.com/science/article/pii/S2211124721007622
  218. Jun 2021
  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sperm Behavior and Response to Melatonin under Capacitating Conditions in Three Sheep Breeds Subject to the Equatorial Photoperiod
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      DOI: 10.3390/ani11061828

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    Pumilio2 and Staufen2 selectively balance the synaptic proteome
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    SARS-CoV-2 infection induces beta cell transdifferentiation
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  222. May 2021
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    Kindlin-3 Mutation in Mesenchymal Stem Cells Results in Enhanced Chondrogenesis
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    Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue
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    A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy
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    Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex
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    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  230. Apr 2021
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    The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria
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    Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
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    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
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    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation
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      DOI: 10.7554/eLife.63886

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  237. Mar 2021
  238. journals.sagepub.com journals.sagepub.com
    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
    1
    1. scibot 31 Mar 2021
      IRDye 800CW donkey anti-rabbit

      DOI: 10.1177/0271678X211002297

      Resource: (LI-COR Biosciences Cat# 926-32213, RRID:AB_621848)

      Curator: @Naa003

      SciCrunch record: RRID:AB_621848

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      RRID:AB_621848 RRIDCUR:Missing
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    journals.sagepub.com/doi/full/10.1177/0271678X211002297
  239. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
    1
    1. scibot 26 Mar 2021
      RRID:AB_621848

      DOI: 10.1016/j.cub.2021.02.061

      Resource: (LI-COR Biosciences Cat# 926-32213, RRID:AB_621848)

      Curator: @Naa003

      SciCrunch record: RRID:AB_621848

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      RRID:AB_621848 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0960982221003055
  240. www.sciencedirect.com www.sciencedirect.com
    Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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    1. scibot 03 Mar 2021
      RRID:AB_621848

      DOI: 10.1016/j.celrep.2021.108777

      Resource: (LI-COR Biosciences Cat# 926-32213, RRID:AB_621848)

      Curator: @Naa003

      SciCrunch record: RRID:AB_621848

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      RRIDCUR:Validated RRID:AB_621848
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    sciencedirect.com/science/article/pii/S2211124721000905
  241. www.sciencedirect.com www.sciencedirect.com
    Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
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    1. scibot 03 Mar 2021
      RRID:AB_621848

      DOI: 10.1016/j.celrep.2021.108760

      Resource: (LI-COR Biosciences Cat# 926-32213, RRID:AB_621848)

      Curator: @Naa003

      SciCrunch record: RRID:AB_621848

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      RRIDCUR:Validated RRID:AB_621848
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    sciencedirect.com/science/article/pii/S2211124721000735
  242. www.sciencedirect.com www.sciencedirect.com
    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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    1. scibot 01 Mar 2021
      RRID:AB_621848

      DOI: 10.1016/j.cell.2020.11.018

      Resource: (LI-COR Biosciences Cat# 926-32213, RRID:AB_621848)

      Curator: @scibot

      SciCrunch record: RRID:AB_621848

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      RRID:AB_621848
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    sciencedirect.com/science/article/pii/S009286742031535X