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    Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells
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    Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition
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  4. Apr 2024
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    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
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    Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10042602/
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    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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    sciencedirect.com/science/article/pii/S0092867424003039
  10. Mar 2024
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    A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
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    sciencedirect.com/science/article/pii/S2666979X24000685
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    A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
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    sciencedirect.com/science/article/pii/S2211124724003097
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    OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
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    Dual effects of TGF-β inhibitor in ALS - inhibit contracture and neurodegeneration
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    Non-random spatial organization of telomere varies during the cell cycle and requires LAP2 and BAF
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    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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    Primary cilia as a tumor marker in pituitary neuroendocrine tumors
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    Pneumococcal sialidase promotes bacterial survival by fine-tuning of pneumolysin-mediated membrane disruption
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    Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia
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    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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    Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease
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    Liver Androgen Receptor Knockout Improved High-fat Diet Induced Glucose Dysregulation in Female Mice But Not Male Mice
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    Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia
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    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
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    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer
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    FGF9 is required for Purkinje cell development and function in the cerebellum
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    The cyclimids: Degron-inspired cereblon binders for targeted protein degradation
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    Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells
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      DOI: 10.1186/s12915-024-01829-w

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  38. Jan 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
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    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway
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    Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p
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    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    TRPC4 deletion elicits behavioral defects in sociability by dysregulating expression of microRNA-138-2
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection
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    Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization
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    BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1-mediated methylation of H3R17
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    Integrative genomic analyses identify lncRNA regulatory networks across pediatric leukemias and solid tumors
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    CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance
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    Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serotonin receptor subtype-2B signaling is associated with interleukin-18-induced cardiomyoblast hypertrophy in vitro
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    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
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    Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome
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    Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
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    Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas
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    SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
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    Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal
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    Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression
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    Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells
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    Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer
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    Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
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    Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment.
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  127. Apr 2023
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    Regulation of sertoli cell function by planar cell polarity (PCP) protein Fjx1
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    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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    DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat
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  131. link.springer.com link.springer.com
    Higher replication potential of West Nile virus governs apoptosis induction in human neuroblastoma cells
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    LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment
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    Combating breast cancer progression through combination therapy with hypomethylating agent and glucocorticoid
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    CD95/Fas ligand mRNA is toxic to cells through more than one mechanism
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      DOI: 10.1186/s43556-023-00119-1

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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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    Revisiting the Effects of Exercise on Cerebral Neurovascular Functions in Rats Using Multimodal Assessment Techniques
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  138. Mar 2023
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    Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis
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  140. europepmc.org europepmc.org
    UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS
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    Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
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    S100A8/S100A9 promote progression of multiple myeloma via expansion of megakaryocytes
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    LMAN1 is a receptor for house dust mite allergens
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    Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1
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    KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization
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    Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
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    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
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  148. Feb 2023
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    PIMT regulates Hepatic Gluconeogenesis in Mice
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      DOI: 10.1016/j.isci.2023.106120

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    Differential Gene Expression Pattern of Importin β3 and NS5 in C6/36 Cells Acutely and Persistently Infected with Dengue Virus 2
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      DOI: 10.3390/pathogens12020191

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    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
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    Evaluation of Epithelial–Mesenchymal Transition Markers in Autoimmune Thyroid Diseases
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1
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  154. Jan 2023
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    Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
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    EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
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      DOI: 10.7554/eLife.79432

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    Transcriptomic profiling reveals sex-specific molecular signatures of adipose endothelial cells under obesogenic conditions
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    Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis
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    The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair
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    Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models
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    Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes
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    The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
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      DOI: 10.1038/s41419-022-05494-1

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  163. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
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    Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses
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  165. Dec 2022
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    Tumor necrosis factor is a necroptosis-associated alarmin
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  167. www.sciencedirect.com www.sciencedirect.com
    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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  168. www.cmghjournal.org www.cmghjournal.org
    Klebsiella pneumoniae induces inflammatory bowel disease through caspase-11-mediated IL-18 in the gut epithelial cells
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
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    Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals
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  174. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics
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    Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke
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    ADAMTS9-AS1 Long Non‑coding RNA Sponges miR‑128 and miR-150 to Regulate Ras/MAPK Signaling Pathway in Glioma
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  178. aacrjournals.org aacrjournals.org
    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
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    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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    Hippocampal parvalbumin interneurons play a critical role in memory development
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    DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
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    An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
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    Mepirapim, a novel synthetic cannabinoid, induces Parkinson’s disease-related behaviors by causing maladaptation of the dopamine system in the brain
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    Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease
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    MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation
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  186. journals.lww.com journals.lww.com
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    The Rb/E2F axis is a key regulator of the molecular signatures instructing the quiescent and activated adult neural stem cell state
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  190. academic.oup.com academic.oup.com
    Granulosa Cell Dysfunction Is Associated with Diminished Ovarian Response in FMR1 Premutation Carriers
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  191. Oct 2022
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    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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  193. 52.53.155.43 52.53.155.43
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  194. link.springer.com link.springer.com
    Shrimp miR-965 transfers tumoricidal mitochondria
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    MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling
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    Circulating exosomal lncRNA contributes to the pathogenesis ... : Neural Regeneration Research
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    Rapamycin Cannot Reduce Seizure Susceptibility in Infantile Rats with Malformations of Cortical Development Lacking mTORC1 Activation
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    GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
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    Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development
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    Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment
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    Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly
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    Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
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    Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells
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    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
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    A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis
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    Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance
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    SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis
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    The lack of Bmal1, a core clock gene, in the intestine decreases glucose absorption in mice
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
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