61 Matching Annotations
  1. Jul 2025
  2. www.cell.com www.cell.com
    Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip
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    cell.com/cell-reports-medicine/abstract/S2666-3791(25)00317-9
  3. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
  4. www.nature.com www.nature.com
    A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients
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    nature.com/articles/s41594-025-01610-9
  5. Jun 2025
  6. www.sciencedirect.com www.sciencedirect.com
    PLK1-mediated PDHA1 phosphorylation drives mitochondrial dysfunction, mitophagy, and cancer progression in Cr(VI)-associated lung cancer
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    sciencedirect.com/science/article/pii/S0021925825022562
  7. www.sciencedirect.com www.sciencedirect.com
    The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders
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    sciencedirect.com/science/article/pii/S221112472500600X
  8. May 2025
  9. www.sciencedirect.com www.sciencedirect.com
    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    sciencedirect.com/science/article/pii/S1097276525004083
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging
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    pmc.ncbi.nlm.nih.gov/articles/PMC11533445/
  11. Apr 2025
  12. www.sciencedirect.com www.sciencedirect.com
    RAF1 kinase contributes to autophagic lysosome reformation
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    sciencedirect.com/science/article/pii/S221112472500261X
  13. Feb 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
  16. Jan 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17
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    pmc.ncbi.nlm.nih.gov/articles/PMC11718230/
  18. Dec 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels
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    sciencedirect.com/science/article/pii/S0021925824025250
  20. Nov 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    sciencedirect.com/science/article/pii/S096098222401457X
  22. Aug 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
  24. Jul 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215108/
  26. May 2024
  27. www.sciencedirect.com www.sciencedirect.com
    A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
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    sciencedirect.com/science/article/pii/S0092867424004677
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
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    onlinelibrary.wiley.com/doi/10.1111/tra.12936
  29. Mar 2024
  30. rupress.org rupress.org
    Rab32 family proteins regulate autophagosomal components recycling
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    rupress.org/jcb/article/223/3/e202306040/276549/Rab32-family-proteins-regulate-autophagosomal
  31. www.sciencedirect.com www.sciencedirect.com
    Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease
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    sciencedirect.com/science/article/pii/S1097276524001254
  32. Dec 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  34. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  36. www.sciencedirect.com www.sciencedirect.com
    P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2
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    sciencedirect.com/science/article/pii/S2211124723015139
  37. Aug 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Staphylococcus aureus phagocytosis is affected by senescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10423838/
  39. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal
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    sciencedirect.com/science/article/pii/S2211124723010094
  40. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
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    sciencedirect.com/science/article/abs/pii/S1097276523005269
  41. Jun 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    sciencedirect.com/science/article/pii/S2211124723006277
  43. www.sciencedirect.com www.sciencedirect.com
    Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2
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    sciencedirect.com/science/article/pii/S2211124723006125
  44. Apr 2023
  45. www.science.org www.science.org
    An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation
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    science.org/doi/10.1126/sciadv.adf8966
  46. www.sciencedirect.com www.sciencedirect.com
    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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    sciencedirect.com/science/article/pii/S2211124723003273
  47. Oct 2022
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9519628/
  49. Sep 2022
  50. www.sciencedirect.com www.sciencedirect.com
    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    sciencedirect.com/science/article/pii/S2211124722012694
  51. www.sciencedirect.com www.sciencedirect.com
    Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy
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    sciencedirect.com/science/article/pii/S2211124722011779
  52. Jul 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide
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    sciencedirect.com/science/article/pii/S2589004222008963
  54. Apr 2022
  55. www.nature.com www.nature.com
    Recycling of autophagosomal components from autolysosomes by the recycler complex
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    nature.com/articles/s41556-022-00861-8
  56. Mar 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S2589004222001390
  58. Feb 2022
  59. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    embopress.org/doi/abs/10.15252/embj.2021108119
  60. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    sciencedirect.com/science/article/pii/S1097276522000028
  61. Aug 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis
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    sciencedirect.com/science/article/pii/S266637912100224X
  63. elifesciences.org elifesciences.org
    Untitled document
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    elifesciences.org/articles/31326
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5780041/
  65. Jul 2021
  66. www.sciencedirect.com www.sciencedirect.com
    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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    sciencedirect.com/science/article/pii/S1550413119301330
  67. www.sciencedirect.com www.sciencedirect.com
    Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
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    sciencedirect.com/science/article/pii/S0092867416309904
  68. www.sciencedirect.com www.sciencedirect.com
    Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release
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    sciencedirect.com/science/article/pii/S0960982221008174
  69. May 2021
  70. www.sciencedirect.com www.sciencedirect.com
    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    sciencedirect.com/science/article/pii/S1534580720309254
  71. www.sciencedirect.com www.sciencedirect.com
    Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation
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    sciencedirect.com/science/article/pii/S1534580720306663
  72. Feb 2021
  73. www.nature.com www.nature.com
    Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress
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    nature.com/articles/s42255-020-00325-z
  74. Jan 2021
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  76. Jan 2020
  77. www.sciencedirect.com www.sciencedirect.com
    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
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    sciencedirect.com/science/article/pii/S2211124719310009
  78. elifesciences.org elifesciences.org
    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
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    elifesciences.org/articles/46188
  79. www.sciencedirect.com www.sciencedirect.com
    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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    sciencedirect.com/science/article/pii/S1535610819300522
  80. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1550413118307575
  81. www.sciencedirect.com www.sciencedirect.com
    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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    sciencedirect.com/science/article/pii/S1550413119301330
  82. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
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    physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP276022
  83. Nov 2018
  84. elifesciences.org elifesciences.org
    Untitled document
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    elifesciences.org/articles/36620
  85. www.sciencedirect.com www.sciencedirect.com
    Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain
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    sciencedirect.com/science/article/pii/S1550413118303267
  86. Nov 2017
  87. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z