402 Matching Annotations
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  2. 52.53.155.43 52.53.155.43
    2025.08.28.672006v1.full-html.html
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    Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface
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    sciencedirect.com/science/article/pii/S2211124725009659
  4. Aug 2025
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70176
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    The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells
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    science.org/doi/10.1126/scisignal.ads7002
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    Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
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    Desmosomal cadherin tension loss in pemphigus vulgaris mediated by the inhibition of active RhoA at cell-cell adhesions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307676/
  9. Jul 2025
  10. www.biorxiv.org www.biorxiv.org
    Interaction of IRS2 with PLK1 protects cells from mitotic stress
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    biorxiv.org/content/10.1101/2025.07.17.665461v1
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281688/
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    PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease
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  14. Jun 2025
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    Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux
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    tandfonline.com/doi/abs/10.1080/15548627.2025.2466144
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    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
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    Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
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    sciencedirect.com/science/article/pii/S2405471225001541
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    Synaptic activity causes minute-scale changes in BAF complex composition and function
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    sciencedirect.com/science/article/pii/S1097276525004563
  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuroprotective potential of carvacrol: restoration of oxidative balance and mitigation of brain injury markers in isoproterenol-induced rats
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    pmc.ncbi.nlm.nih.gov/articles/PMC12102131/
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    Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk-stimulated mouse MA-10 Leydig cells
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    onlinelibrary.wiley.com/doi/10.1111/andr.70051
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    Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048568/
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    Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity
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    sciencedirect.com/science/article/pii/S2590006425003606
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    Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer
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    sciencedirect.com/science/article/pii/S0021925825004089
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    Enhanced differentiation of neural progenitor cells in Alzheimer’s disease into vulnerable immature neurons
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    Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
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    Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses
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  28. Apr 2025
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    SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases
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    The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
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    METTL3-mediated m6A modification regulates the polycomb repressive complex 1 (PRC1) components BMI1 and RNF2 in hepatocellular carcinoma cells
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    ARC/ARG3.1 binds the nuclear polyadenylate-binding protein RRM and regulates neuronal activity-dependent formation of nuclear speckles
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    Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11960706/
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    A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions
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  36. Mar 2025
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    Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer
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    Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction
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    Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs
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    IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
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    Synergistic effects of HO-1 inhibition and chemotherapy on tumor proliferation and immune infiltration: An in vitro and in vivo approach to enhancing prostate cancer treatment
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  43. Feb 2025
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    Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations
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    Tumor Treating Fields enhance chemotherapy efficacy by increasing cellular drug uptake and retention in mesothelioma cells
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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  48. Jan 2025
  49. elifesciences.org elifesciences.org
    SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis
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    elifesciences.org/reviewed-preprints/98152
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    Blood-derived APLP1+ extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases
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    Calcium level and autophagy defect in GNE mutants of rare neuromuscular disorder
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    LDB1 establishes multi-enhancer networks to regulate gene expression
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  54. Dec 2024
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    Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma
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    Physiological shedding and C-terminal proteolytic processing of TMEM106B
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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  60. Nov 2024
  61. www.cell.com www.cell.com
    Formate promotes invasion and metastasis in reliance on lipid metabolism
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  62. Oct 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  64. Sep 2024
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    A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2
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    A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain
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    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
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  68. Aug 2024
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    Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy
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    The conformational plasticity of structurally unrelated lipid transport proteins correlates with their mode of action
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    Small GTPase ActIvitY ANalyzing (SAIYAN) system: A method to detect GTPase activation in living cells
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    Adaptive changes in group-II metabotropic glutamate receptors underlie the deficit in recognition memory induced by methamphetamine in mice
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    Targeting heme degradation pathway augments prostate cancer cell sensitivity to docetaxel-induced apoptosis and attenuates migration
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    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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    Alamandine enhances cardiomyocyte contractility in hypertensive rats through a nitric oxide-dependent activation of CaMKII | American Journal of Physiology-Cell Physiology
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    Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex
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    onlinelibrary.wiley.com/doi/10.1002/cne.23691/full
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    A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer
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  79. Jul 2024
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of small molecule inhibitors of G3BP-driven stress granule formation
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    RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
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    Effects of non-rapid eye movement sleep on the cortical synaptic expression of GluA1-containing AMPA receptors
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    onlinelibrary.wiley.com/doi/10.1111/ejn.16460
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    Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity
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    Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves c2c12 myotube diameter in an in vitro model of cancer cachexia
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  85. Jun 2024
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    β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo
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    link.springer.com/article/10.1007/s43440-024-00614-4
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    Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions
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  88. May 2024
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    Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids
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    ATG9B regulates bacterial internalization via actin rearrangement
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    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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  92. Apr 2024
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    O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability
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    Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
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    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
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  98. Mar 2024
  99. link.springer.com link.springer.com
    Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
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    ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition
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    Eukaryotic release factor 1 from Euplotes promotes frameshifting at premature stop codons in human cells
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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  204. Sep 2022
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    Hepatic ER stress suppresses adipose browning through ATF4-CIRP-ANGPTL3 cascade
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    CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression
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  208. Aug 2022
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation
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    Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer
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    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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    Discovery of compounds that reactivate p53 mutants in vitro and in vivo
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  214. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    T-cell dysfunction upon expression of MYC with altered phosphorylation at Threonine 58 and Serine 62
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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    Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
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    Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells
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  220. Jun 2022
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    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine
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  224. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
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    Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer
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    SETD4-mediated KU70 methylation suppresses apoptosis
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    Excitation–Contraction Coupling: Calcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
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  230. Apr 2022
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    The role of PTEN in primary sensory neurons in processing itch and thermal information in mice
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