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FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102365
  
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sciencedirect.com/science/article/pii/S2666379125004380
May 2025
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1-s2.0-S2589004225008454-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112584
  
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52.53.155.43/2f59eea255f6dfa2798e1e0fcb3d7e10d3ba6bc8/1-s2.0-S2589004225008454-main-html.html
Dec 2024
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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

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1. scibot 03 Dec 2024
  
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  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Nov 2024
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Plausible, robust biological oscillations through allelic buffering

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.cels.2024.10.002
  
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sciencedirect.com/science/article/pii/S2405471224002990
Aug 2024
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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114622
  
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sciencedirect.com/science/article/pii/S2211124724009720
Apr 2024
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

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1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.04.002
  
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sciencedirect.com/science/article/pii/S0092867424003970
Jul 2023
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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112833
  
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sciencedirect.com/science/article/pii/S2211124723008446
Jun 2023
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112693
  
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sciencedirect.com/science/article/pii/S2211124723007040
Mar 2023
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The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112288
  
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sciencedirect.com/science/article/pii/S2211124723002991
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FAM193A is a positive regulator of p53 activity

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112230
  
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sciencedirect.com/science/article/pii/S2211124723002413
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Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease

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1. scibot 04 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112198
  
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sciencedirect.com/science/article/pii/S2211124723002097
Jan 2023
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Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111972
  
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sciencedirect.com/science/article/pii/S2211124722018769
Nov 2022
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p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness

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1. scibot 22 Nov 2022
  
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  DOI: 10.1158/1078-0432.CCR-22-1357
  
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aacrjournals.org/clincancerres/article/28/21/4757/709842/p53-Inhibits-Bmi-1-driven-Self-Renewal-and-Defines
Oct 2022
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ccr-22-1357-html.html

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1. scibot 27 Oct 2022
  
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  DOI: 10.1158/1078-0432.ccr-22-1357
  
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52.53.155.43/b06e31323fa05ae99a3ee4406ee4cfeac8533d8b/ccr-22-1357-html.html
Sep 2022
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Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors

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1. scibot 21 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111396
  
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sciencedirect.com/science/article/pii/S2211124722012335
Aug 2022
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SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111233
  
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sciencedirect.com/science/article/pii/S2211124722010506
Nov 2021
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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1. scibot 18 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.10.017
  
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sciencedirect.com/science/article/pii/S1097276521009096
Aug 2021
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Untitled document

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1. scibot 05 Aug 2021
  
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  DOI: 10.1016/j.cmet.2018.07.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6224545/
Jul 2021
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Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate

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1. scibot 31 Jul 2021
  
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  DOI: 10.1016/j.celrep.2019.03.058
  
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sciencedirect.com/science/article/pii/S2211124719303882
onlinelibrary.wiley.com onlinelibrary.wiley.com

Linc‐ROR regulates apoptosis in esophageal squamous cell carcinoma via modulation of p53 ubiquitination by targeting miR‐204‐5p/MDM2

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1. scibot 30 Jul 2021
  
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  Anti‐MDM2
  
  DOI: 10.1002/jcp.29139
  
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onlinelibrary.wiley.com/doi/full/10.1002/jcp.29139
May 2021
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POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.05.012
  
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sciencedirect.com/science/article/pii/S1097276520303130
Apr 2021
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A selective p53 activator and anticancer agent to improve colorectal cancer therapy

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1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108982
  
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sciencedirect.com/science/article/pii/S2211124721002965
Jan 2021
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BRD4-mediated repression of p53 is a target for combination therapy in AML

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1. scibot 24 Jan 2021
  
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  DOI: 10.1038/s41467-020-20378-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7801601/
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest

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1. scibot 20 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108240
  
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pubmed.ncbi.nlm.nih.gov/33053351/
Sep 2020
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The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107846
  
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sciencedirect.com/science/article/pii/S2211124720308275
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PRMT1-p53 Pathway Controls Epicardial EMT and Invasion

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107739
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7425665/
Jan 2020
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Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing

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1. scibot 13 Jan 2020
  
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sciencedirect.com/science/article/pii/S2211124719311088
elifesciences.org elifesciences.org

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.34836
  
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elifesciences.org/articles/34836
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2019.01.006
  
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sciencedirect.com/science/article/pii/S1535610819300406
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MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network

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  DOI: 10.1016/j.molcel.2019.02.012
  
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sciencedirect.com/science/article/pii/S1097276519301029
Nov 2018
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Untitled document

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sciencedirect.com/science/article/pii/S1550413118304480
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USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms

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sciencedirect.com/science/article/pii/S2451945617303306
europepmc.org europepmc.org

Untitled document

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1. scibot 05 Nov 2018
  
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europepmc.org/articles/PMC5957528/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC5957528/
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Untitled document

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sciencedirect.com/science/article/pii/S245194561730329X
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Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation

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1. scibot 05 Nov 2018
  
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  RRID:AB_627920
  
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  (Santa Cruz Biotechnology Cat# sc-965, RRID:AB_627920)
  
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sciencedirect.com/science/article/pii/S1097276517308444
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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

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1. scibot 05 Nov 2018
  
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  RRID:AB_627920
  
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  (Santa Cruz Biotechnology Cat# sc-965, RRID:AB_627920)
  
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sciencedirect.com/science/article/pii/S1535610817304646
Nov 2017
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Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

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1. scibot 08 Nov 2017
  
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  RRID:AB_627920
  
  Curator: @Jmenke
  
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  RRID:AB_627920 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276517305749