98 Matching Annotations
  1. Oct 2025
  2. www.science.org www.science.org
    Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses
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    science.org/doi/10.1126/sciadv.adw4618
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    Isoformic PD-1 impedes B cell activation and function in HIV-1 infection
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    sciencedirect.com/science/article/pii/S221112472501112X
  4. Sep 2025
  5. www.sciencedirect.com www.sciencedirect.com
    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    sciencedirect.com/science/article/pii/S2211124725010484
  6. Aug 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322803/
  8. Jul 2025
  9. www.sciencedirect.com www.sciencedirect.com
    Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling
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    sciencedirect.com/science/article/pii/S2211124725008617
  10. Jun 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169444/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
  13. May 2025
  14. www.sciencedirect.com www.sciencedirect.com
    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    sciencedirect.com/science/article/pii/S1097276525004083
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A lncRNA-mediated metabolic rewiring of cell senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12187636/
  16. Apr 2025
  17. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/d82b50f0340a265ea39586fdf6016ce1aa48cfa1/PDF-html.html
  18. Mar 2025
  19. www.sciencedirect.com www.sciencedirect.com
    The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2
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    sciencedirect.com/science/article/pii/S1074761325000937
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    Vagal pathway activation links chronic stress to decline in intestinal stem cell function
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    sciencedirect.com/science/article/pii/S1934590925000840
  21. Feb 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies
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    sciencedirect.com/science/article/pii/S2666379125000370
  23. 52.53.155.43 52.53.155.43
    A non-catalytic function for Rad18 in sustaining glioblastoma proliferation
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    52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
  24. Jan 2025
  25. www.sciencedirect.com www.sciencedirect.com
    Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
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    sciencedirect.com/science/article/pii/S1550413124004819
  26. www.sciencedirect.com www.sciencedirect.com
    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    sciencedirect.com/science/article/pii/S2451945624005166
  27. www.sciencedirect.com www.sciencedirect.com
    Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control
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    sciencedirect.com/science/article/pii/S1534580724007639
  28. www.sciencedirect.com www.sciencedirect.com
    Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004224028396
  29. Dec 2024
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo
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    onlinelibrary.wiley.com/doi/10.1111/1440-1681.70012
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    Morphogenesis and regeneration share a conserved core transition cell state program that controls lung epithelial cell fate
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    sciencedirect.com/science/article/pii/S1534580724006993
  32. Nov 2024
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats
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    pmc.ncbi.nlm.nih.gov/articles/PMC11580379/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
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    pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
  36. Sep 2024
  37. www.sciencedirect.com www.sciencedirect.com
    The Role of MFN2 in Regulating Endothelial Cell Senescence: Implications for Vascular Aging
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    sciencedirect.com/science/article/pii/S2589004224020340
  38. Aug 2024
  39. www.sciencedirect.com www.sciencedirect.com
    On the role of p53 in the cellular response to aneuploidy
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    sciencedirect.com/science/article/pii/S2211124721002060
  40. www.biorxiv.org www.biorxiv.org
    Senescent cell clearance ameliorates temporal lobe epilepsy and associated spatial memory deficits in mice
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    biorxiv.org/content/10.1101/2024.07.30.605784v1
  41. Jul 2024
  42. www.cell.com www.cell.com
    Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
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    cell.com/cell-reports/fulltext/S2211-1247(24)00738-1
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11214290/
  45. Apr 2024
  46. www.sciencedirect.com www.sciencedirect.com
    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    sciencedirect.com/science/article/pii/S1550413124001232
  47. www.sciencedirect.com www.sciencedirect.com
    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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    sciencedirect.com/science/article/pii/S0092867424003970
  48. Feb 2024
  49. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  50. www.sciencedirect.com www.sciencedirect.com
    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    sciencedirect.com/science/article/pii/S2666379124000570
  51. Jan 2024
  52. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  53. Oct 2023
  54. www.sciencedirect.com www.sciencedirect.com
    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    sciencedirect.com/science/article/pii/S1097276523007037
  55. Sep 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome
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    sciencedirect.com/science/article/pii/S0002944023003152
  57. Aug 2023
  58. 52.53.155.43 52.53.155.43
    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    52.53.155.43/1bbe45cf5b4e78c7829bbc8558904ff45b580eb3/PIIS2211124723009956-html.html
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    CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis
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    sciencedirect.com/science/article/pii/S2211124723009476
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  61. Jul 2023
  62. anatomypubs.onlinelibrary.wiley.com anatomypubs.onlinelibrary.wiley.com
    Patterns of senescence and apoptosis during development of branchial arches, epibranchial placodes, and pharyngeal pouches
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    anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.637
  63. Jun 2023
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
  65. www.sciencedirect.com www.sciencedirect.com
    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
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    sciencedirect.com/science/article/pii/S0092867423005329
  66. May 2023
  67. www.sciencedirect.com www.sciencedirect.com
    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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    sciencedirect.com/science/article/pii/S2211124723005314
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic miR-21 decoy circularized by tRNA splicing mechanism inhibited tumorigenesis in glioblastoma in vitro and in vivo models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10173299/
  69. www.sciencedirect.com www.sciencedirect.com
    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    sciencedirect.com/science/article/pii/S2211124723004904
  70. Feb 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9901536/
  72. Nov 2022
  73. www.sciencedirect.com www.sciencedirect.com
    Biosensor Cell-Fit-HD4D for correlation of single-cell fate and microscale energy deposition in complex ion beams
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    sciencedirect.com/science/article/pii/S2666166722006785
  74. Sep 2022
  75. www.sciencedirect.com www.sciencedirect.com
    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    sciencedirect.com/science/article/pii/S0021925822009759
  76. www.sciencedirect.com www.sciencedirect.com
    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    sciencedirect.com/science/article/pii/S2211124722012335
  77. Aug 2022
  78. www.sciencedirect.com www.sciencedirect.com
    Increasing cell size remodels the proteome and promotes senescence
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    sciencedirect.com/science/article/pii/S1097276522007134
  79. Jun 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  81. Apr 2022
  82. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
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    sciencedirect.com/science/article/pii/S2211124722004454
  83. Mar 2022
  84. www.sciencedirect.com www.sciencedirect.com
    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    sciencedirect.com/science/article/pii/S153458072200079X
  85. link.springer.com link.springer.com
    Partial p53 reactivation is sufficient to induce cancer regression
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    link.springer.com/article/10.1186/s13046-022-02269-6
  86. Feb 2022
  87. www.sciencedirect.com www.sciencedirect.com
    Biosensor for deconvolution of individual cell fate in response to ion beam irradiation
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    sciencedirect.com/science/article/pii/S2667237522000212
  88. Nov 2021
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8592571/
  90. www.sciencedirect.com www.sciencedirect.com
    Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S2589004221012967
  91. Aug 2021
  92. www.sciencedirect.com www.sciencedirect.com
    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
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    sciencedirect.com/science/article/pii/S2211124721010020
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5658514/
  94. www.ebiomedicine.com www.ebiomedicine.com
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    ebiomedicine.com/article/S2352-3964(16)30525-4/abstract
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6334229/
  96. Jul 2021
  97. www.nature.com www.nature.com
    α-Ketoglutarate links p53 to cell fate during tumour suppression
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    nature.com/articles/s41586-019-1577-5
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
  99. www.sciencedirect.com www.sciencedirect.com
    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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    sciencedirect.com/science/article/pii/S2352396416305254
  100. www.sciencedirect.com www.sciencedirect.com
    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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    sciencedirect.com/science/article/pii/S2211124721007130
  101. Jun 2021
  102. www.sciencedirect.com www.sciencedirect.com
    Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
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    sciencedirect.com/science/article/pii/S2211124721005799
  103. www.sciencedirect.com www.sciencedirect.com
    Bacterial genotoxins induce T cell senescence
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    sciencedirect.com/science/article/pii/S2211124721005714
  104. www.sciencedirect.com www.sciencedirect.com
    ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells
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    sciencedirect.com/science/article/pii/S0301472X21001995
  105. May 2021
  106. mcr.aacrjournals.org mcr.aacrjournals.org
    Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
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    mcr.aacrjournals.org/content/19/5/874
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  108. Mar 2021
  109. www.sciencedirect.com www.sciencedirect.com
    On the role of p53 in the cellular response to aneuploidy
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    sciencedirect.com/science/article/pii/S2211124721002060
  110. www.sciencedirect.com www.sciencedirect.com
    PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells
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    sciencedirect.com/science/article/pii/S1097276521000150
  111. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001855RR
  112. Feb 2021
  113. www.sciencedirect.com www.sciencedirect.com
    Unique signatures of stress-induced senescent human astrocytes
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    sciencedirect.com/science/article/pii/S0014488620302971
  114. Oct 2020
  115. www.sciencedirect.com www.sciencedirect.com
    Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos
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    sciencedirect.com/science/article/pii/S1534580720304147
  116. Sep 2020
  117. www.sciencedirect.com www.sciencedirect.com
    TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages
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    sciencedirect.com/science/article/pii/S2211124720303065
  118. www.sciencedirect.com www.sciencedirect.com
    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    sciencedirect.com/science/article/pii/S2211124720310652
  119. www.sciencedirect.com www.sciencedirect.com
    Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
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    sciencedirect.com/science/article/pii/S2211124720305210
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    Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites
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    sciencedirect.com/science/article/pii/S2211124720307452
  121. Jan 2020
  122. elifesciences.org elifesciences.org
    FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
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    elifesciences.org/articles/47327
  123. elifesciences.org elifesciences.org
    Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
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    elifesciences.org/articles/34836
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    sciencedirect.com/science/article/pii/S2211124718319284
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    sciencedirect.com/science/article/pii/S1535610819300996
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    Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
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    sciencedirect.com/science/article/pii/S155041311930021X
  128. Nov 2018
  129. www.sciencedirect.com www.sciencedirect.com
    The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression
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  130. www.sciencedirect.com www.sciencedirect.com
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    Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging
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  132. europepmc.org europepmc.org
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
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  135. www.sciencedirect.com www.sciencedirect.com
    Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency
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  136. Nov 2017
  137. www.nature.com www.nature.com
    Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism
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    nature.com/articles/s41598-017-09228-8
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    Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
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    Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early Molecular Stratification of High-risk Primary Biliary Cholangitis
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