73 Matching Annotations
  1. Sep 2026
  2. www.nature.com www.nature.com
    Neuroprotective effects of empagliflozin and metformin combined therapy on rotenone induced Parkinsonism in Wistar rats via PI3K and PPARγ modulation
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    nature.com/articles/s41598-026-68289-w
  3. Aug 2026
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    Gut microbiota and uric acid excretion signaling in pathogenesis of hyperuricemia and acute gouty arthritis
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    sciencedirect.com/science/article/pii/S2589004226024508
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    Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37 to promote tumor progression
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    sciencedirect.com/science/article/pii/S2211124726009150
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JI017 Sensitizes EGFR-T790M NSCLC to Erlotinib by Extinguishing the STAT3–Survivin Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13438235/
  7. May 2026
  8. aacrjournals.org aacrjournals.org
    CCL1-AMFR facilitates glioblastoma progression by modulating the crosstalk between glioma cells and tumor-associated macrophages
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    aacrjournals.org/cancerimmunolres/article/14/4/676/776525/CCL1-AMFR-Facilitates-Glioblastoma-Progression-by
  9. Feb 2026
  10. www.sciencedirect.com www.sciencedirect.com
    Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis
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  11. Dec 2025
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    Akt2 regulates autophagy and osteogenesis in diabetic osteoporosis via PI3K/AKT/mTOR signaling axis
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    sciencedirect.com/science/article/pii/S8756328225003825
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  14. Oct 2025
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    Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity
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  16. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
  18. Jul 2025
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
  20. Jun 2025
  21. journals.sagepub.com journals.sagepub.com
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    journals.sagepub.com/doi/full/10.1177/15347354251344592
  22. www.sciencedirect.com www.sciencedirect.com
    Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells
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  23. May 2025
  24. 52.53.155.43 52.53.155.43
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    Sumoylated Etv1 establishes mouse mammary cancer stem cells that support tumorigenesis by non-stem cancer cells
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  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
  27. Apr 2025
  28. 52.53.155.43 52.53.155.43
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  29. www.jneurosci.org www.jneurosci.org
    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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  30. Feb 2025
  31. aacrjournals.org aacrjournals.org
    Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling
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  32. aacrjournals.org aacrjournals.org
    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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    aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
  33. Jan 2025
  34. www.sciencedirect.com www.sciencedirect.com
    Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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  35. Dec 2024
  36. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  37. Sep 2024
  38. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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  40. Aug 2024
  41. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    link.springer.com/article/10.1007/s12035-024-04425-9
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11317932/
  43. www.sciencedirect.com www.sciencedirect.com
    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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  44. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    sciencedirect.com/science/article/pii/S1535610824002708
  45. Jul 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  47. May 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
  49. Mar 2024
  50. www.sciencedirect.com www.sciencedirect.com
    MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2405844024042038
  51. Feb 2024
  52. link.springer.com link.springer.com
    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    link.springer.com/article/10.1007/s12010-024-04887-6
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
  54. Jan 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  56. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
  57. Aug 2023
  58. link.springer.com link.springer.com
    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
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    link.springer.com/article/10.1007/s10967-023-09067-0
  59. Jul 2023
  60. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    sciencedirect.com/science/article/pii/S221112472300880X
  61. www.sciencedirect.com www.sciencedirect.com
    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    sciencedirect.com/science/article/pii/S2589004223014189
  62. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    sciencedirect.com/science/article/pii/S2211124723008057
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
  64. Jun 2023
  65. 52.53.155.43 52.53.155.43
    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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  66. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  67. Mar 2023
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla
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    onlinelibrary.wiley.com/doi/10.1111/cns.14142
  69. Dec 2022
  70. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
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    sciencedirect.com/science/article/pii/S1550413122005034
  71. Nov 2022
  72. link.springer.com link.springer.com
    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    link.springer.com/article/10.1007/s13402-022-00737-x
  73. Sep 2022
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
  75. Jul 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell
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    ncbi.nlm.nih.gov/pmc/articles/PMC9316729/
  77. Jun 2022
  78. 52.53.155.43 52.53.155.43
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  79. journals.lww.com journals.lww.com
    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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  80. May 2022
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    HDAC inhibition prevents hypobaric hypoxia‐induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.30337
  82. Mar 2022
  83. www.sciencedirect.com www.sciencedirect.com
    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    sciencedirect.com/science/article/pii/S2211124722002893
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC8899187/
  85. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15733
  86. Dec 2021
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15693
  88. Jul 2021
  89. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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    jcs.biologists.org/content/132/20/jcs233221
  90. May 2021
  91. www.sciencedirect.com www.sciencedirect.com
    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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  92. Feb 2021
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  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  95. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  96. Dec 2020
  97. link.springer.com link.springer.com
    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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    link.springer.com/article/10.1007/s10495-020-01645-x
  98. Sep 2020
  99. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  100. www.sciencedirect.com www.sciencedirect.com
    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    sciencedirect.com/science/article/pii/S0006295220301775
  101. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  103. www.mdpi.com www.mdpi.com
    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
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    mdpi.com/2077-0383/9/2/353
  104. Jan 2020
  105. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    sciencedirect.com/science/article/pii/S1074761319304960
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcb.29123
  107. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14626
  108. Nov 2018
  109. link.springer.com link.springer.com
    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
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    link.springer.com/article/10.1007/s10571-018-0616-3
  110. academic.oup.com academic.oup.com
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    academic.oup.com/endo/article/159/9/3132/5050928
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    Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity
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    sciencedirect.com/science/article/pii/S1074761317304879
  112. Nov 2017
  113. academic.oup.com academic.oup.com
    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
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    academic.oup.com/endo/article/158/10/3661/4049499/Aldose-Reductase-Mediates-NLRP3-Inflammasome
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    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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    academic.oup.com/endo/article/158/3/560/2930939/Dual-Role-of-Insulin-in-Spexin-Regulation