51 Matching Annotations
  1. Sep 2024
  2. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
    1
    1. scibot 27 Sep 2024
      AB_659940

      DOI: 10.1113/JP286715

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286715
  3. www.sciencedirect.com www.sciencedirect.com
    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114762

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    sciencedirect.com/science/article/pii/S2211124724011136
  4. Aug 2024
  5. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
    1
    1. scibot 25 Aug 2024
      RRID:AB_659940

      DOI: 10.1007/s12035-024-04425-9

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    link.springer.com/article/10.1007/s12035-024-04425-9
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
    1
    1. scibot 21 Aug 2024
      RRID:AB_659940

      DOI: 10.4103/NRR.NRR-D-23-01889

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    ncbi.nlm.nih.gov/pmc/articles/PMC11317932/
  7. www.sciencedirect.com www.sciencedirect.com
    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.mce.2024.112341

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    sciencedirect.com/science/article/pii/S0303720724001977
  8. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.ccell.2024.07.005

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    sciencedirect.com/science/article/pii/S1535610824002708
  9. Jul 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
    1
    1. scibot 06 Jul 2024
      AB_659940

      DOI: 10.3892/or.2024.8760

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  11. May 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
    1
    1. scibot 23 May 2024
      RRID:AB_659940

      DOI: 10.1016/j.isci.2024.109829

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    ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
  13. Mar 2024
  14. www.sciencedirect.com www.sciencedirect.com
    MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer
    1
    1. scibot 21 Mar 2024
      RRID:AB_659940

      DOI: 10.1016/j.heliyon.2024.e28172

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    sciencedirect.com/science/article/pii/S2405844024042038
  15. Feb 2024
  16. link.springer.com link.springer.com
    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
    1
    1. scibot 22 Feb 2024
      RRID:AB_659940

      DOI: 10.1007/s12010-024-04887-6

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    link.springer.com/article/10.1007/s12010-024-04887-6
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
    1
    1. scibot 16 Feb 2024
      RRID:_AB_659940

      DOI: 10.1016/j.isci.2024.108926

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    ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
  18. Jan 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
    1
    1. scibot 18 Jan 2024
      RRID:AB_659940

      DOI: 10.1016/j.isci.2023.108725

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  20. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
      RRID:AB_659940

      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  21. Aug 2023
  22. link.springer.com link.springer.com
    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
    1
    1. scibot 16 Aug 2023
      RRID:AB_659940

      DOI: 10.1007/s10967-023-09067-0

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    link.springer.com/article/10.1007/s10967-023-09067-0
  23. Jul 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
    1
    1. scibot 27 Jul 2023
      RRID:AB_659940

      DOI: 10.1016/j.celrep.2023.112869

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    sciencedirect.com/science/article/pii/S221112472300880X
  25. www.sciencedirect.com www.sciencedirect.com
    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
    1
    1. scibot 21 Jul 2023
      RRID:AB_659940

      DOI: 10.1016/j.isci.2023.107341

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    sciencedirect.com/science/article/pii/S2589004223014189
  26. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
    1
    1. scibot 21 Jul 2023
      RRID:AB_659940

      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
    1
    1. scibot 12 Jul 2023
      RRID:AB_659940

      DOI: 10.1126/sciadv.adg9593

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    ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
  28. Jun 2023
  29. 52.53.155.43 52.53.155.43
    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
    1
    1. scibot 15 Jun 2023
      RRID:AB_659940

      DOI: 10.1210/endocr/bqad091

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    52.53.155.43/505020cd5ddad21196b5171a72c7e74f4f7d8201/bqad091-html.html
  30. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 01 Jun 2023
      RRID:AB_659940

      DOI: 10.1111/bph.16080

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  31. Mar 2023
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla
    1
    1. scibot 01 Mar 2023
      RRID:AB_659940

      DOI: 10.1111/cns.14142

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    onlinelibrary.wiley.com/doi/10.1111/cns.14142
  33. Dec 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
    1
    1. scibot 17 Dec 2022
      RRID:AB_659940

      DOI: 10.1016/j.cmet.2022.11.012

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    sciencedirect.com/science/article/pii/S1550413122005034
  35. Nov 2022
  36. link.springer.com link.springer.com
    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
    1
    1. scibot 05 Nov 2022
      RRID:AB_659940

      DOI: 10.1007/s13402-022-00737-x

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    link.springer.com/article/10.1007/s13402-022-00737-x
  37. Sep 2022
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
    1
    1. scibot 30 Sep 2022
      RRID:AB_659940

      DOI: 10.3389/fimmu.2022.931087

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
  39. Jul 2022
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell
    1
    1. scibot 30 Jul 2022
      AB_659940

      DOI: 10.1186/s13048-022-01021-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC9316729/
  41. Jun 2022
  42. 52.53.155.43 52.53.155.43
    mct-21-0848-html.html
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    1. scibot 30 Jun 2022
      RRID:AB_659940

      DOI: 10.1158/1535-7163.mct-21-0848

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    52.53.155.43/12e7b7b771463d8107a4061a3543e1c33fbd2829/mct-21-0848-html.html
  43. journals.lww.com journals.lww.com
    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
    1
    1. scibot 24 Jun 2022
      RRID:AB_659940

      DOI: 10.4103/1673-5374.344840

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    journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
  44. May 2022
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    HDAC inhibition prevents hypobaric hypoxia‐induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway
    1
    1. scibot 28 May 2022
      phosphor‐PI3K

      DOI: 10.1002/jcp.30337

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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.30337
  46. Mar 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
    1
    1. scibot 23 Mar 2022
      RRID:AB_659940

      DOI: 10.1016/j.celrep.2022.110548

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    sciencedirect.com/science/article/pii/S2211124722002893
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
    1
    1. scibot 09 Mar 2022
      AB_659940

      DOI: 10.3389/fimmu.2022.837497

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    ncbi.nlm.nih.gov/pmc/articles/PMC8899187/
  49. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 02 Mar 2022
      RRID:AB_2630365

      DOI: 10.1111/bph.15733

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15733
  50. Dec 2021
  51. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 21 Dec 2021
      RRID:AB_659940

      DOI: 10.1111/bph.15693

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15693
  52. Jul 2021
  53. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    1
    1. scibot 31 Jul 2021
      P-PI3-kinase p85Tyr458/p55Tyr199

      DOI: 10.1242/jcs.233221

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    jcs.biologists.org/content/132/20/jcs233221
  54. May 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2021.03.008

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    sciencedirect.com/science/article/pii/S0896627321001562
  56. Feb 2021
  57. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 25 Feb 2021
      AB_659940

      DOI: 10.1111/bph.15047

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15047
  58. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
    1
    1. scibot 24 Feb 2021
      AB_659940

      DOI: 10.1002/jcb.29312

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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  59. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 24 Feb 2021
      RRID:AB_659940

      DOI: 10.1016/j.celrep.2020.01.012

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  60. Dec 2020
  61. link.springer.com link.springer.com
    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
    1
    1. scibot 07 Dec 2020
      Phospho-PI3 Kinase p85

      DOI: 10.1007/s10495-020-01645-x

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      Curator comments: Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody Cell Signaling Technology Cat# 4228

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    link.springer.com/article/10.1007/s10495-020-01645-x
  62. Sep 2020
  63. www.cell.com www.cell.com
    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
    1
    1. scibot 23 Sep 2020
      RRID:AB_659940

      DOI: 10.1016/j.celrep.2020.01.012

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

      Curator: @ethanbadger

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    cell.com/cell-reports/abstract/S2211-1247(20)30021-8
  64. www.sciencedirect.com www.sciencedirect.com
    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
    1
    1. scibot 11 Sep 2020
      RRID:AB_659940

      DOI: 10.1016/j.bcp.2020.113949

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

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    sciencedirect.com/science/article/pii/S0006295220301775
  65. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 10 Sep 2020
      RRID:AB_659940

      DOI: 10.1111/bph.14918

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

      Curator: @Naa003

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14918
  66. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 09 Sep 2020
      RRID:AB_659940

      DOI: 10.1111/bph.15042

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

      Curator: @Naa003

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      RRIDCUR:Validated RRID:AB_659940
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15042
  67. www.mdpi.com www.mdpi.com
    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
    1
    1. scibot 04 Sep 2020
      anti-pPI3K

      DOI: 10.3390/jcm9020353

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

      Curator: @Naa003

      SciCrunch record: RRID:AB_659940

      Curator comments: Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody Cell Signaling Technology Cat# 4228

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    mdpi.com/2077-0383/9/2/353
  68. Jan 2020
  69. www.sciencedirect.com www.sciencedirect.com
    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    1. scibot 13 Jan 2020
      RRID:AB_659940

      DOI: 10.1016/j.immuni.2019.11.015

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      Curator: @ethanbadger

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      RRID:AB_659940 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761319304960
  70. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
    1
    1. scibot 13 Jan 2020
      RRID:AB_659940

      DOI: 10.1002/jcb.29123

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

      Curator: @Naa003

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      RRID:AB_659940 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/full/10.1002/jcb.29123
  71. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_659940

      DOI: 10.1111/bph.14626

      Resource: (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14626
  72. Nov 2018
  73. link.springer.com link.springer.com
    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
    1
    1. scibot 05 Nov 2018
      AB_659940

      Curator: @evieth

      Curator note: Cell Signaling Technology Cat# 4228, Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody

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    link.springer.com/article/10.1007/s10571-018-0616-3
  74. academic.oup.com academic.oup.com
    Untitled document
    1
    1. scibot 05 Nov 2018
      RRID:AB_659940

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      (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

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    academic.oup.com/endo/article/159/9/3132/5050928
  75. www.sciencedirect.com www.sciencedirect.com
    Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity
    1
    1. scibot 05 Nov 2018
      RRID:AB_659940

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      (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

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    sciencedirect.com/science/article/pii/S1074761317304879
  76. Nov 2017
  77. academic.oup.com academic.oup.com
    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
    1
    1. scibot 08 Nov 2017
      AB_659940

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    academic.oup.com/endo/article/158/10/3661/4049499/Aldose-Reductase-Mediates-NLRP3-Inflammasome
  78. academic.oup.com academic.oup.com
    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
    1
    1. scibot 08 Nov 2017
      AB_659940

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 4228, RRID:AB_659940)

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    academic.oup.com/endo/article/158/3/560/2930939/Dual-Role-of-Insulin-in-Spexin-Regulation