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L-asparaginase treatment induces a tumor metabolic plasticity and reveals a vulnerability to PARP1/2 inhibitor Olaparib, in B-cell lymphomas

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1. scibot 30 Oct 2025
  
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  DOI: 10.1101/2025.10.24.683536
  
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biorxiv.org/content/10.1101/2025.10.24.683536v1
Sep 2025
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TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells

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  DOI: 10.1016/j.celrep.2025.116260
  
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sciencedirect.com/science/article/pii/S2211124725010319
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Efficacy of ATR Kinase Inhibitor Elimusertib Monotherapy or Combination in Tumors with DNA Damage Response Pathway and Other Genomic Alterations

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0884
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402799/
Jun 2025
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

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  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
May 2025
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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.isci.2025.112567
  
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sciencedirect.com/science/article/pii/S2589004225008284
Apr 2025
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
Jul 2024
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PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html

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1. scibot 23 Jul 2024
  
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52.53.155.43/dff7bc1da9f5df512f47678d2bc141ea46c650fc/PPAR_Interaction_with_UBR5_ATMIN_Promot-html.html
Mar 2024
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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.010
  
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sciencedirect.com/science/article/pii/S1097276524001291
Feb 2024
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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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1. scibot 23 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113845
  
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sciencedirect.com/science/article/pii/S2211124724001736
Dec 2023
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Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin

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1. scibot 15 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113555
  
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sciencedirect.com/science/article/pii/S221112472301567X
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

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1. scibot 12 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Jun 2023
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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112668
  
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sciencedirect.com/science/article/pii/S2211124723006794
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Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.05.015
  
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sciencedirect.com/science/article/pii/S1097276523003714
Apr 2023
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Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

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1. scibot 20 Apr 2023
  
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  DOI: 10.1126/sciadv.ade7997
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10104471/
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Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

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  DOI: 10.1126/sciadv.ade7997
  
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science.org/doi/10.1126/sciadv.ade7997
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ERCC6L2 mitigates replication stress and promotes centromere stability

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112329
  
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sciencedirect.com/science/article/pii/S2211124723003406
Dec 2022
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The ADP-ribose hydrolase NUDT5 is important for DNA repair

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111866
  
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sciencedirect.com/science/article/pii/S2211124722017624
Sep 2022
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DNA-PKcs promotes fork reversal and chemoresistance

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1. scibot 22 Sep 2022
  
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  DOI: 10.1016/j.molcel.2022.08.028
  
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sciencedirect.com/science/article/pii/S1097276522008486
Aug 2022
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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.07.011
  
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sciencedirect.com/science/article/pii/S1097276522007079
May 2022
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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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  DOI: 10.1016/j.molcel.2022.04.030
  
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sciencedirect.com/science/article/pii/S1097276522003938
Jan 2022
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WASH interacts with Ku to regulate DNA double-stranded break repair

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  DOI: 10.1016/j.isci.2021.103676
  
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sciencedirect.com/science/article/pii/S2589004221016461
Dec 2021
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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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1. scibot 08 Dec 2021
  
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  DOI: 10.1016/j.cmet.2021.11.011
  
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sciencedirect.com/science/article/pii/S1550413121005398
Oct 2021
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Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

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1. scibot 19 Oct 2021
  
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  DOI: 10.1186/s13046-021-02124-0
  
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link.springer.com/article/10.1186/s13046-021-02124-0
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Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair

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1. scibot 16 Oct 2021
  
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  DOI: 10.1016/j.neuron.2021.09.040
  
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sciencedirect.com/science/article/pii/S0896627321007133
Aug 2021
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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

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1. scibot 10 Aug 2021
  
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  DOI: 10.1016/j.cell.2018.11.024
  
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sciencedirect.com/science/article/pii/S0092867418315162
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Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

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1. scibot 07 Aug 2021
  
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  DOI: 10.15252/embj.2020107413
  
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embopress.org/doi/abs/10.15252/embj.2020107413
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Untitled document

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  DOI: 10.1523/JNEUROSCI.4213-15.2016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5296783/
Jul 2021
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Untitled document

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  DOI: 10.1016/j.celrep.2018.09.060
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6205844/
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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.devcel.2018.09.021
  
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sciencedirect.com/science/article/pii/S1534580718307810
Mar 2021
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

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1. scibot 03 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108808
  
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sciencedirect.com/science/article/pii/S2211124721001224
Jan 2020
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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

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  DOI: 10.1016/j.celrep.2019.07.070
  
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sciencedirect.com/science/article/pii/S221112471930974X
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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.09.024
  
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sciencedirect.com/science/article/pii/S1097276519307294
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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.05.036
  
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sciencedirect.com/science/article/pii/S1097276519304332
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.01.013
  
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sciencedirect.com/science/article/pii/S221112471930021X
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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

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  DOI: 10.1016/j.ccell.2019.02.004
  
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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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  Rabbit polyclonal anti-Phospho KAP-1 (S824)Bethyl / Universal BiologicalsCat# A300-767
  
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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

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A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

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