612 Matching Annotations
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  3. Oct 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
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    pmc.ncbi.nlm.nih.gov/articles/PMC12483517/
  5. Sep 2025
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    RIPK1 autophosphorylation at S161 mediates cell death and inflammation
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    rupress.org/jem/article/222/12/e20250279/278339/RIPK1-autophosphorylation-at-S161-mediates-cell
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    Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
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    sciencedirect.com/science/article/pii/S2666979X25002423
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    Dynamic Expression of α-Internexin in the Chicken Pineal Gland: A Study of Developmental, Structural, and Functional Roles
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    onlinelibrary.wiley.com/doi/10.1002/jmor.70081
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    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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    Epigenetic modulation of BARD1 to enhance anti-VEGF therapy
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  12. Aug 2025
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    LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model
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    MAVS phosphorylation acts as a cellular stress sensor that modulates antiviral immunity
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    Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321798/
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    Plasma hepcidin level is elevated by water immersion‐induced central fatigue via hepatic inflammatory response in male and female rats
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    PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
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  19. Jul 2025
  20. rupress.org rupress.org
    Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways
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    Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy
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    Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer
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    Expression and function of β-site amyloid precursor protein cleaving enzyme 2 in vascular endothelium | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society
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    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
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    RECLASSIFICATION OF ATM MISSENSE VARIANTS OF UNCERTAIN SIGNIFICANCE BY INTEGRATING RESULTS FROM SYSTEMATIC FUNCTIONAL ASSAYS INTO AN ACMG POINTS-BASED FRAMEWORK
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  27. Jun 2025
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    Plinabulin following radiation enhances dendritic cell maturation and checkpoint inhibitor retreatment of relapsed/refractory cancers
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    MET pathway inhibition increases chemo-immunotherapy efficacy in small cell lung cancer
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    Bisecting GlcNAc modification of angiotensin-related glycoproteins in mouse kidney
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    Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection
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    Characterization of the N-terminal region of Crtac1B/LOTUS, an endogenous Nogo receptor-1 antagonist, required for secretion and soluble function
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  36. May 2025
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    Expression of Mitochondrial Uncoupling Proteins and GABA Signaling Molecules in Unstimulated and Nerve Growth Factor–Stimulated PC12 Cells: Models for Chromaffin Cells and Sympathetic Neurons
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    A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation
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    Modulation of GABAergic System in a Chicken Retinal Ischemic Model: The Role of Chloride Cotransporters
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  41. Apr 2025
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    SLC25A11, a Novel Gene Associated with Carney-Stratakis Syndrome
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    Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle
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    Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies
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    Mucosal multivalent NDV-based vaccine provides cross-reactive immune responses against SARS-CoV-2 variants in animal models
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  47. Mar 2025
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    Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism
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    Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation
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    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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    Engineering mtDNA deletions by reconstituting end joining in human mitochondria
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  53. Feb 2025
  54. www.biorxiv.org www.biorxiv.org
    Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle
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    Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia
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    MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling
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    Protocol for assessing the clogging of the mitochondrial translocase of the outer membrane by precursor proteins in human cells
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    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis
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    GUK1 activation is a metabolic liability in lung cancer
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  62. Jan 2025
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs
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    CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition
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    Phospho-regulation of ASCL1-mediated chromatin opening during cellular reprogramming
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    TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells
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    Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
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  68. Dec 2024
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction
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    A single immunization with intranasal Newcastle disease virus (NDV)-based XBB.1.5 variant vaccine reduces disease and transmission in animals against matched-variant challenge
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    Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression
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    Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway
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    DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells
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    Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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  78. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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  83. Sep 2024
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    C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology
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    Synaptotagmin‐7 enhances calcium‐sensing of chromaffin cell granules and slows discharge of granule cargos
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    Ghrelin-Induced Sodium Reabsorption is Mediated by PKA and Microtubule-Dependent αE Na C Translocation In Female Rats
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    FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants
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    Multiple direct and indirect roles of the Paf1 complex in transcription elongation, splicing, and histone modifications
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    The ribosome collision sensor Hel2 functions as preventive quality control in the secretory pathway
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    Disorder-mediated interactions target proteins to specific condensates
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  92. Aug 2024
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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    Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function
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    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II
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    Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
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    Differential effect of asparagine and glutamine removal on three adenocarcinoma cell lines
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    Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency
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