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41 Matching Annotations

Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

1
1. scibot 27 Sep 2025
  
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  RRID:AB_776632
  
  DOI: 10.7554/eLife.106901
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459955/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TBK1 Targeting is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids

1
1. scibot 05 Aug 2025
  
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  AB_776632
  
  DOI: 10.1158/2326-6066.CIR-23-1011
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790382/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

1
1. scibot 19 Apr 2025
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease

1
1. scibot 30 Jan 2025
  
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  RRID:AB_776632
  
  DOI: 10.4103/NRR.NRR-D-23-01684
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11759022/
Dec 2024
www.sciencedirect.com www.sciencedirect.com

The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

1
1. scibot 24 Dec 2024
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2024.115094
  
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sciencedirect.com/science/article/pii/S2211124724014451
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

1
1. scibot 23 Mar 2024
  
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  RRID:AB_776632
  
  DOI: 10.7554/eLife.88122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

2
1. scibot 01 Mar 2024
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2024.113870
  
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2. scibot 01 Mar 2024
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2024.113870
  
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sciencedirect.com/science/article/pii/S2211124724001980
Jan 2024
www.sciencedirect.com www.sciencedirect.com

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

1
1. scibot 19 Jan 2024
  
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  AB_776632
  
  DOI: 10.1016/j.isci.2023.108760
  
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sciencedirect.com/science/article/pii/S2589004223028377
Nov 2023
www.embopress.org www.embopress.org

SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

1
1. scibot 03 Nov 2023
  
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  RRID:AB_776632
  
  DOI: 10.15252/embr.202357500
  
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embopress.org/doi/10.15252/embr.202357500
Oct 2023
www.sciencedirect.com www.sciencedirect.com

Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity

1
1. scibot 27 Oct 2023
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2023.113261
  
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sciencedirect.com/science/article/pii/S2211124723012731
Apr 2023
www.biorxiv.org www.biorxiv.org

Optineurin provides a mitophagy contact site for TBK1 activation

1
1. scibot 12 Apr 2023
  
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  RRID:AB_776632
  
  DOI: 10.1101/2023.02.24.529790
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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biorxiv.org/content/10.1101/2023.02.24.529790v1
Mar 2023
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NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

1
1. scibot 02 Mar 2023
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2023.112185
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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sciencedirect.com/science/article/pii/S2211124723001961
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

1
1. scibot 16 Feb 2023
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.nbd.2023.106043
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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sciencedirect.com/science/article/pii/S0969996123000578
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates

1
1. scibot 05 Jan 2023
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2022.111949
  
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sciencedirect.com/science/article/pii/S2211124722018502
Dec 2022
www.sciencedirect.com www.sciencedirect.com

The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

1
1. scibot 24 Dec 2022
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2022.111868
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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sciencedirect.com/science/article/pii/S2211124722017648
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

1
1. scibot 03 Dec 2022
  
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  AB_776632
  
  DOI: 10.3389/fphar.2022.1020670
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9714675/
May 2022
www.sciencedirect.com www.sciencedirect.com

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

1
1. scibot 11 May 2022
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.immuni.2022.04.006
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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sciencedirect.com/science/article/pii/S1074761322001777
Sep 2021
www.sciencedirect.com www.sciencedirect.com

The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

1
1. scibot 22 Sep 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2021.109731
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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sciencedirect.com/science/article/pii/S2211124721011803
Aug 2021
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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

1
1. scibot 03 Aug 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.cmet.2021.07.009
  
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sciencedirect.com/science/article/pii/S1550413121003259
Jul 2021
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

7
1. scibot 27 Jul 2021
  
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  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Unrecognized RRID:AB_776632
2. scibot 27 Jul 2021
  
  in Public
  
  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Unrecognized RRID:AB_776632
3. scibot 27 Jul 2021
  
  in Public
  
  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Unrecognized RRID:AB_776632
4. scibot 27 Jul 2021
  
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  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_776632
5. scibot 27 Jul 2021
  
  in Public
  
  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_776632
6. scibot 27 Jul 2021
  
  in Public
  
  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Validated RRID:AB_776632
7. scibot 27 Jul 2021
  
  in Public
  
  AB_776632
  
  DOI: 10.1186/s12915-016-0292-z
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @gabimpine
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Validated RRID:AB_776632
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scibot

URL

bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z
Jun 2021
www.cell.com www.cell.com

Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

1
1. scibot 25 Jun 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.molcel.2021.06.004
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00451-2
May 2021
www.sciencedirect.com www.sciencedirect.com

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

1
1. scibot 11 May 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.isci.2021.102477
  
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sciencedirect.com/science/article/pii/S2589004221004454
www.sciencedirect.com www.sciencedirect.com

Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

1
1. scibot 07 May 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.immuni.2020.11.010
  
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sciencedirect.com/science/article/pii/S1074761320304970
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

1
1. scibot 22 Apr 2021
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.ccell.2021.01.003
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_776632
  
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  RRIDCUR:Validated RRID:AB_776632
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sciencedirect.com/science/article/pii/S1535610821000416
Dec 2020
www.sciencedirect.com www.sciencedirect.com

Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

1
1. scibot 12 Dec 2020
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2020.108490
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
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  RRID:AB_776632 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720314790
Sep 2020
www.sciencedirect.com www.sciencedirect.com

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

1
1. scibot 16 Sep 2020
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.neuron.2020.03.005
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @ethanbadger
  
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  RRID:AB_776632 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627320301914
www.cell.com www.cell.com

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

1
1. scibot 04 Sep 2020
  
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  RRID: AB_776632
  
  DOI: 10.1016/j.celrep.2018.11.097
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @evieth
  
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cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_776632
  
  DOI: 10.1016/j.celrep.2018.11.097
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @evieth
  
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  RRID:AB_776632 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718318886
www.sciencedirect.com www.sciencedirect.com

Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_776632
  
  DOI: 10.1016/j.immuni.2019.01.014
  
  Resource: (Abcam Cat# ab40676, RRID:AB_776632)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_776632
  
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  RRID:AB_776632 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761319300378
Nov 2018
www.sciencedirect.com www.sciencedirect.com

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

1
1. scibot 05 Nov 2018
  
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  RRID: 776632
  
  Curator: @Jmenke
  
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  (Abcam Cat# ab40676, RRID:AB_776632)
  
  SciCrunch record: RRID:AB_776632
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_776632 RRIDCUR:SyntaxError
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sciencedirect.com/science/article/pii/S1074761318303558
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_776632
  
  Curator: @evieth
  
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  SciCrunch record: RRID:AB_776632
  
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  RRID:AB_776632 RRIDCUR:Validated
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scibot

URL

bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0507-6
www.sciencedirect.com www.sciencedirect.com

Dampened STING-Dependent Interferon Activation in Bats

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_776632
  
  Curator: @Jmenke
  
  Resource used:
  
  (Abcam Cat# ab40676, RRID:AB_776632)
  
  SciCrunch record: RRID:AB_776632
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_776632 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_776632

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scibot

URL

sciencedirect.com/science/article/pii/S1931312818300416
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_776632
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Abcam Cat# ab40676, RRID:AB_776632)
  
  SciCrunch record: RRID:AB_776632
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_776632 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_776632

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URL

sciencedirect.com/science/article/pii/S1931312817302032
www.sciencedirect.com www.sciencedirect.com

Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_776632
  
  Curator: @Zeljana_Babic
  
  Resource used:
  
  (Abcam Cat# ab40676, RRID:AB_776632)
  
  SciCrunch record: RRID:AB_776632
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_776632 RRIDCUR:Validated
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RRIDCUR:Validated

RRID:AB_776632

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URL

sciencedirect.com/science/article/pii/S1074761317301309