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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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  DOI: 10.1016/j.immuni.2026.06.002
  
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sciencedirect.com/science/article/pii/S1074761326002530
Jun 2026
54.241.53.176 54.241.53.176

Targeting ERLIN1 reveals a coordinated cholesterol-dependent vulnerability in hepatocellular carcinoma

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1. scibot 20 Jun 2026
  
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  DOI: 10.3350/cmh.2025.1157
  
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54.241.53.176/bf88d95789389f32d043367dc0db82344a10fd26/cmh-2025-1157-Supplementary-Table-9-html.html
Apr 2026
aacrjournals.org aacrjournals.org

Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/2326-6066.CIR-25-0242
  
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aacrjournals.org/cancerimmunolres/article/14/3/478/774853/Immunotherapy-Inhibits-Tumor-Cholesterol-Synthesis
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma

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1. scibot 20 Feb 2026
  
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  DOI: 10.1038/s44321-025-00349-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12905276/
Jan 2026
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The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation

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  DOI: 10.1016/j.isci.2025.114267
  
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sciencedirect.com/science/article/pii/S2589004225025283
Dec 2025
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An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116681
  
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sciencedirect.com:5037/science/article/pii/S2211124725014536
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
Feb 2025
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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115339
  
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sciencedirect.com/science/article/pii/S221112472500110X
Jan 2025
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Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115203
  
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sciencedirect.com/science/article/pii/S2211124724015547
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication

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1. scibot 19 Jul 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301072/
May 2024
www.mdpi.com www.mdpi.com

Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function

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1. scibot 21 May 2024
  
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  DOI: 10.3390/ijms25105417
  
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mdpi.com/1422-0067/25/10/5417
52.53.155.43 52.53.155.43

Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

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1. scibot 16 May 2024
  
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  DOI: 10.1101/2024.02.22.581558
  
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52.53.155.43/8391d5e75ba57c9ef8c1ebe0973fe3c1602760fc/2024.02.22.581558v3.full-html.html
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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

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1. scibot 03 May 2024
  
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  DOI: 10.1016/j.cell.2024.04.005
  
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sciencedirect.com/science/article/pii/S0092867424004008
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

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1. scibot 08 Feb 2024
  
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  DOI: 10.7554/eLife.91656
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10846857/
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures

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1. scibot 28 Dec 2023
  
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  DOI: 10.3389/fnmol.2023.1323431
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
Oct 2023
www.embopress.org www.embopress.org

Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth

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1. scibot 03 Oct 2023
  
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  DOI: 10.15252/embj.2023114032
  
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embopress.org/doi/10.15252/embj.2023114032
Sep 2023
journals.physiology.org journals.physiology.org

CircFOXN2 alleviates glucocorticoid- and tacrolimus-induced dyslipidemia by reducing FASN mRNA stability by binding to PTBP1 during liver transplantation

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1. scibot 15 Sep 2023
  
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  DOI: 10.1152/ajpcell.00462.2022
  
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journals.physiology.org/doi/10.1152/ajpcell.00462.2022
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Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients

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1. scibot 07 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107727
  
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sciencedirect.com/science/article/pii/S2589004223018047
Jul 2023
52.53.155.43 52.53.155.43

cd-22-0411-html.html

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  DOI: 10.1158/2159-8290.cd-22-0411
  
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52.53.155.43/453457acda6208aed297e8061921a5c2d2ddddf2/cd-22-0411-html.html
May 2023
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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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1. scibot 27 May 2023
  
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  DOI: 10.1016/j.ccell.2023.04.016
  
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sciencedirect.com/science/article/pii/S1535610823001423
Dec 2022
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Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages

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1. scibot 01 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111738
  
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sciencedirect.com/science/article/pii/S2211124722016163
Aug 2022
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Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

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1. scibot 30 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104941
  
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sciencedirect.com/science/article/pii/S2589004222012135
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis

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1. scibot 30 Aug 2022
  
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sciencedirect.com/science/article/pii/S1550413122003485
Jun 2022
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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1. scibot 24 Jun 2022
  
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  DOI: 10.1016/j.cell.2022.05.017
  
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sciencedirect.com/science/article/pii/S0092867422006481
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

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1. scibot 28 Sep 2021
  
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  DOI: 10.1016/j.isci.2021.103089
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8449244/
Jul 2021
www.nature.com www.nature.com

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

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  DOI: 10.1038/s41586-021-03762-2
  
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nature.com/articles/s41586-021-03762-2
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Untitled document

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  DOI: 10.1016/j.cell.2018.11.011
  
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Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.immuni.2018.08.021
  
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sciencedirect.com/science/article/pii/S1074761318303844
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ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

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  DOI: 10.1016/j.isci.2021.102758
  
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sciencedirect.com/science/article/pii/S2589004221007264
Jun 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2‐mediated mechanism

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1. scibot 25 Jun 2021
  
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  DOI: 10.1111/bph.15433
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15433
May 2021
www.cell.com www.cell.com

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

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1. scibot 20 May 2021
  
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  Rabbit anti-SREBP2
  
  DOI: 10.1016/j.cmet.2021.05.006
  
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cell.com/cell-metabolism/fulltext/S1550-4131(21)00223-0
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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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  DOI: 10.1016/j.molcel.2021.04.009
  
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sciencedirect.com/science/article/pii/S1097276521003142
Apr 2021
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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.08.015
  
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sciencedirect.com/science/article/pii/S1535610820304268
Sep 2020
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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.01.003
  
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sciencedirect.com/science/article/pii/S1097276520300034
Jan 2020
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The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.06.005
  
  Resource: (Abcam Cat# ab30682, RRID:AB_779079)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_779079
  
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  RRID:AB_779079 RRIDCUR:Validated
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RRID:AB_779079

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sciencedirect.com/science/article/pii/S1074761319302754
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_779079
  
  DOI: 10.1016/j.celrep.2019.11.067
  
  Resource: (Abcam Cat# ab30682, RRID:AB_779079)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_779079
  
  What is this?
  
  RRID:AB_779079 RRIDCUR:Validated
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RRID:AB_779079

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sciencedirect.com/science/article/pii/S221112471931558X
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_779079
  
  DOI: 10.1016/j.cell.2019.10.034
  
  Resource: (Abcam Cat# ab30682, RRID:AB_779079)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_779079
  
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  RRID:AB_779079 RRIDCUR:Validated
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RRID:AB_779079

RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S0092867419312115
academic.oup.com academic.oup.com

Intestine-Specific Overexpression of LDLR Enhances Cholesterol Excretion and Induces Metabolic Changes in Male Mice

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_779079
  
  DOI: 10.1210/en.2018-00098
  
  Resource: (Abcam Cat# ab30682, RRID:AB_779079)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_779079
  
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  RRID:AB_779079 RRIDCUR:Validated
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academic.oup.com/endo/article/160/4/744/5251728
Nov 2018
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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_779079
  
  Curator: @Jmenke
  
  Resource used:
  
  (Abcam Cat# ab30682, RRID:AB_779079)
  
  SciCrunch record: RRID:AB_779079
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_779079 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867418310365
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Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo

2
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_779079
  
  Curator: @evieth
  
  Resource used:
  
  (Abcam Cat# ab30682, RRID:AB_779079)
  
  SciCrunch record: RRID:AB_779079
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_779079 RRIDCUR:Validated
2. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_779079
  
  Curator: @evieth
  
  Resource used:
  
  (Abcam Cat# ab30682, RRID:AB_779079)
  
  SciCrunch record: RRID:AB_779079
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_779079 RRIDCUR:Validated
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RRID:AB_779079

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sciencedirect.com/science/article/pii/S1550413117305545