167 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia
    1
    1. scibot 07 Jun 2024
      RRID:AB_796208

      DOI: 10.1152/ajpcell.00374.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC10243536/
  3. 52.53.155.43 52.53.155.43
    elife-90203-v1-html.html
    2
    1. scibot 06 Jun 2024
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      DOI: 10.7554/elife.90203

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      DOI: 10.7554/elife.90203

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    52.53.155.43/e16f8eb78126f87544f972ae1c5bea05ef0e60ed/elife-90203-v1-html.html
  4. May 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Local glycolysis fuels actomyosin contraction during axonal retraction
    1
    1. scibot 03 May 2024
      RRID:AB_796208

      DOI: 10.1083/jcb.202206133

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    ncbi.nlm.nih.gov/pmc/articles/PMC10616508/
  6. Mar 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias
    1
    1. scibot 16 Mar 2024
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      DOI: 10.1038/s44319-024-00077-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
    2
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113886

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    2. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113886

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    ncbi.nlm.nih.gov/pmc/articles/PMC11019558/
  9. Feb 2024
  10. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.10.05.561021

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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  11. 52.53.155.43 52.53.155.43
    Identification of an H-Ras nanocluster disrupting peptide
    2
    1. scibot 22 Feb 2024
      RRID:AB_796208

      DOI: 10.1101/2023.09.07.556635

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    2. scibot 22 Feb 2024
      RRID:AB_796208

      DOI: 10.1101/2023.09.07.556635

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    52.53.155.43/50febc729cb1f3f2f29f241e3592121bf7d8fba9/2023.09.07.556635v1.full-html.html
  12. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.08.23.554263

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    52.53.155.43/d64025fcba7405c73976a9e0dc65e9989e0d835f/2023.08.23.554263v1.full-html.html
  13. www.embopress.org www.embopress.org
    Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1038/s44319-024-00077-x

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    embopress.org/doi/10.1038/s44319-024-00077-x
  14. Jan 2024
  15. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.039

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    sciencedirect.com/science/article/pii/S1097276523010857
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers
    1
    1. scibot 05 Jan 2024
      AB_796208

      DOI: 10.1042/BCJ20230380

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    ncbi.nlm.nih.gov/pmc/articles/PMC10754287/
  17. Dec 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay
    1
    1. scibot 20 Dec 2023
      RRID:AB_796208

      DOI: 10.1016/j.xcrm.2023.101330

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    sciencedirect.com/science/article/pii/S2666379123005475
  19. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
      RRID:AB_796208

      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  20. Oct 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin
    2
    1. scibot 21 Oct 2023
      RRID:AB_796208

      DOI: 10.1016/j.celrep.2023.113254

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      DOI: 10.1016/j.celrep.2023.113254

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    sciencedirect.com/science/article/pii/S2211124723012664
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
    1
    1. scibot 21 Oct 2023
      RRID:AB_796208

      DOI: 10.1016/j.isci.2023.108142

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    ncbi.nlm.nih.gov/pmc/articles/PMC10585400/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
    1
    1. scibot 18 Oct 2023
      RRID: AB_796208

      DOI: 10.3390/cells12192389

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    ncbi.nlm.nih.gov/pmc/articles/PMC10571842/
  24. 52.53.155.43 52.53.155.43
    BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
    1
    1. scibot 13 Oct 2023
      RRID:AB_796208

      DOI: 10.1101/2023.06.14.544924

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    52.53.155.43/5afe577c269e488702b5f7086020251c9f5e047d/2023.06.14.544924v1.full-html.html
  25. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
    1
    1. scibot 06 Oct 2023
      RRID:AB_796208

      DOI: 10.1016/j.yexmp.2023.104874

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    sciencedirect.com/science/article/pii/S0014480023000254
  26. Sep 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction
    1
    1. scibot 30 Sep 2023
      RRID:AB_796208

      DOI: 10.1016/j.isci.2023.107746

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    ncbi.nlm.nih.gov/pmc/articles/PMC10514471/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
    1
    1. scibot 07 Sep 2023
      RRID:AB_796208

      DOI: 10.4103/1673-5374.375347

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    ncbi.nlm.nih.gov/pmc/articles/PMC10479865/
  29. Aug 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation
    1
    1. scibot 26 Aug 2023
      RRID:AB_796208

      DOI: 10.7554/eLife.84752

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    ncbi.nlm.nih.gov/pmc/articles/PMC10431918/
  31. link.springer.com link.springer.com
    Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke
    1
    1. scibot 16 Aug 2023
      RRID:AB_796208

      DOI: 10.1007/s12975-023-01183-z

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    link.springer.com/article/10.1007/s12975-023-01183-z
  32. elifesciences.org elifesciences.org
    Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
    1
    1. scibot 05 Aug 2023
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      DOI: 10.7554/eLife.85309

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    elifesciences.org/articles/85309
  33. Jul 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
    1
    1. scibot 21 Jul 2023
      RRID:AB_796208

      DOI: 10.1016/j.molcel.2023.06.025

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    sciencedirect.com/science/article/pii/S1097276523004720
  35. Jun 2023
  36. www.sciencedirect.com www.sciencedirect.com
    High-throughput longitudinal electrophysiology screening of mature chamber-specific hiPSC-CMs using optical mapping
    1
    1. scibot 29 Jun 2023
      RRID:AB_796208

      DOI: 10.1016/j.isci.2023.107142

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    sciencedirect.com/science/article/pii/S2589004223012191
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterizing microglial senescence: Tau as a key player
    1
    1. scibot 08 Jun 2023
      RRID:AB_796208

      DOI: 10.1111/jnc.15866

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15866
  38. Apr 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112442

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    sciencedirect.com/science/article/pii/S2211124723004539
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice
    1
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      DOI: 10.1002/jnr.25153

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    ncbi.nlm.nih.gov/pmc/articles/PMC10107949/
  41. Mar 2023
  42. europepmc.org europepmc.org
    Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
    1
    1. scibot 23 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112275

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    europepmc.org/article/med/36943864
  43. www.sciencedirect.com www.sciencedirect.com
    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
    1
    1. scibot 11 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112221

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    sciencedirect.com/science/article/pii/S2211124723002322
  44. www.sciencedirect.com www.sciencedirect.com
    Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus
    1
    1. scibot 10 Mar 2023
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      DOI: 10.1016/j.neuron.2023.02.020

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    sciencedirect.com/science/article/pii/S0896627323001241
  45. www.cell.com www.cell.com
    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
    1
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      DOI: 10.1016/j.molcel.2023.02.023

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    cell.com/molecular-cell/abstract/S1097-2765(23)00150-8
  46. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Colchicine exerts anti-atherosclerotic and ‑plaque-stabilizing effects targeting foam cell formation
    1
    1. scibot 04 Mar 2023
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      DOI: 10.1096/fj.202201469R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201469R
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The effect of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly
    1
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      DOI: 10.1111/jnc.15763

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15763
  48. academic.oup.com academic.oup.com
    O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules
    1
    1. scibot 02 Mar 2023
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      DOI: 10.1093/glycob/cwad006

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    academic.oup.com/glycob/advance-article/doi/10.1093/glycob/cwad006/7017701
  49. Feb 2023
  50. www.nature.com www.nature.com
    CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells
    1
    1. scibot 15 Feb 2023
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      DOI: 10.1038/s41598-023-29437-8

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    nature.com/articles/s41598-023-29437-8
  51. www.sciencedirect.com www.sciencedirect.com
    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
    1
    1. scibot 10 Feb 2023
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      DOI: 10.1016/j.isci.2023.106073

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    sciencedirect.com/science/article/pii/S2589004223001505
  52. Jan 2023
  53. www.cell.com www.cell.com
    Wolbachia RNase HI contributes to virus blocking in the mosquito Aedes aegypti
    1
    1. scibot 15 Jan 2023
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      DOI: 10.1016/j.isci.2022.105836

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  54. Dec 2022
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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  57. Nov 2022
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    Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa
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  59. Oct 2022
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    Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension
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    Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
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  62. Sep 2022
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    Metabolic Profile Variations along the Differentiation of Human-Induced Pluripotent Stem Cells to Dopaminergic Neurons
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  64. Aug 2022
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    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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    β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration
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    Ethanol sustains phosphorylated tau protein in the cultured neonatal rat hippocampus: Implications for fetal alcohol spectrum disorders
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    Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway
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  69. Jul 2022
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    GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
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    The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins
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  72. Jun 2022
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    Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors
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    The ER ladder is a unique morphological feature of developing mammalian axons
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  75. May 2022
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    Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant
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  78. Apr 2022
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    TNFɑ Antagonist in Combination with PD-1 Blocker to Prevent or Retard Malignant Transformation of B[a]P-induced Chronic Lung Inflammation
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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  81. Mar 2022
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    C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth
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    A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
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    Sebocytes contribute to melasma onset
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  85. Jan 2022
  86. www.cell.com www.cell.com
    Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing
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    Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36
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    TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle
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  89. Dec 2021
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    CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway
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    The balance of mitochondrial fission and fusion in cortical axons depends on the kinases SadA and SadB
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  92. Nov 2021
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  94. Oct 2021
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    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination
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  96. Sep 2021
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    Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
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    Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A
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  99. Aug 2021
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    The role of voltage-gated chloride channels in the epileptogenesis of temporal lobe epilepsy
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    miR-194-3p Represses the Progesterone Receptor and Decidualization in Eutopic Endometrium From Women With Endometriosis
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  104. Jul 2021
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    Phosphorylation of Trans-active response DNA binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing
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    A Mechanism for Statin-Induced Susceptibility to Myopathy
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    Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation
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    Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
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  120. Apr 2021
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    Bile‐duct ligation renders the brain susceptible to hypotension induced neuronal degeneration: implications of ammonia
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth
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    A novel HDAC6 inhibitor improves myelination of Schwann cells in a model of Charcot‐Marie‐Tooth disease type 1A
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    Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Cav2.1 C‐terminal fragments produced in Xenopus laevis oocytes do not modify the channel expression and functional properties
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    A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance
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    Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS
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    The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development
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    MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
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    PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis
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    A Mechanism for Statin-Induced Susceptibility to Myopathy
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    Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium
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    ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97
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    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
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    Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2
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    PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells
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  182. Nov 2018
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    Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β
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    A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission
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  185. embomolmed.embopress.org embomolmed.embopress.org
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    Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement
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    Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan
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    DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk
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    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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    SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production
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    Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
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    GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells
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    AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection
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    Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice
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    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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  199. Nov 2017
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    New tools for “hot-wiring” clathrin-mediated endocytosis with temporal and spatial precision
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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mst‐1 deficiency promotes post‐traumatic spinal motor neuron survival via enhancement of autophagy flux
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    The Transcriptome of Estrogen-Independent Mammary Growth in Female Mice Reveals That Not All Mammary Glands Are Created Equally
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  203. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein kinase D exerts neuroprotective functions during oxidative stress via Nuclear Factor kappaB‐independent signaling pathways
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    Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib
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      RRID:AB_796208 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2451945617301848
  205. www.sciencedirect.com www.sciencedirect.com
    Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles
    1
    1. scibot 08 Nov 2017
      AB_796208

      Curator: @chewbeccax

      Resource used:

      (Sigma-Aldrich Cat# G9545, RRID:AB_796208)

      SciCrunch record: RRID:AB_796208

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_796208 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717304227
  206. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
    2
    1. scibot 08 Nov 2017
      AB_796208

      Curator: @gabimpine

      Resource used:

      (Sigma-Aldrich Cat# G9545, RRID:AB_796208)

      SciCrunch record: RRID:AB_796208

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_796208 RRIDCUR:Validated
    2. scibot 08 Nov 2017
      AB_796208

      Curator: @gabimpine

      Resource used:

      (Sigma-Aldrich Cat# G9545, RRID:AB_796208)

      SciCrunch record: RRID:AB_796208

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_796208 RRIDCUR:Validated
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z
  207. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors
    1
    1. scibot 08 Nov 2017
      AB_796208

      Curator: @gabimpine

      Resource used:

      (Sigma-Aldrich Cat# G9545, RRID:AB_796208)

      SciCrunch record: RRID:AB_796208

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_796208 RRIDCUR:Validated
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0257-2