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A SIRT6-OVOL2 axis governs excitatory neuron resilience to chronic stress

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  DOI: 10.1016/j.celrep.2026.118297
  
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sciencedirect.com/science/article/pii/S2211124726013768
Nov 2026
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The AMPK-ALDH7A1 axis drives metabolic reprogramming and anti-tumor immunity in hepatocellular carcinoma via KDM5C inhibition

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  DOI: 10.1016/j.devcel.2026.10.006
  
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sciencedirect.com/science/article/pii/S1534580726003928
Oct 2026
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Microbial inositol phosphates orchestrate host diurnal metabolism and energy homeostasis via HDAC3

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1. scibot 24 Oct 2026
  
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  DOI: 10.1016/j.chom.2026.09.021
  
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sciencedirect.com/science/article/pii/S1931312826004105
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Opposing functions of gut immunomodulatory metabolites on CAR-T therapy

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  DOI: 10.1016/j.cell.2026.09.004
  
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sciencedirect.com/science/article/pii/S0092867426010731
Sep 2026
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4-Phenylbutyric acid activates an NF-κB-Egr-1 axis to control myoblast proliferation and ECM gene expression

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MDL800, an allosteric SIRT6 activator, ameliorates UV-induced skin photoaging by attenuating oxidative stress, DNA damage, and collagen degradation

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1. scibot 16 Sep 2026
  
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  DOI: 10.1016/j.jphotobiol.2026.113567
  
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sciencedirect.com/science/article/pii/S1011134426002149
Aug 2026
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A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

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Jul 2026
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Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life

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  DOI: 10.1038/s44318-026-00851-8
  
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link.springer.com/article/10.1038/s44318-026-00851-8
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Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

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1. scibot 11 Jul 2026
  
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aacrjournals.org/cancerres/article/85/18/3416/764453/Mitochondrial-Calcium-Uniporter-Links-Acetyl-CoA
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H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions

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Apr 2026
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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.004
  
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Mar 2026
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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.012
  
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Jan 2026
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A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages

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1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.immuni.2025.12.010
  
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A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

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  DOI: 10.1016/j.chom.2025.12.002
  
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sciencedirect.com/science/article/pii/S1931312825005219
Oct 2025
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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

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  DOI: 10.1016/j.drup.2025.101312
  
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sciencedirect.com/science/article/pii/S1368764625001153
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SlWRKY14 integrates carotenoid and flavonoid biosynthetic pathways to regulate coloration and quality of tomato fruits

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116369
  
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Sep 2025
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Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate

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1. scibot 24 Sep 2025
  
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Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology

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1. scibot 06 Sep 2025
  
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  DOI: 10.1101/2025.08.29.673140
  
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biorxiv.org/content/10.1101/2025.08.29.673140v1
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Evaluating Endometrial Response to Human Chorionic Gonadotropin: Alterations in Epigenetic Regulation and Extracellular Vesicle Cargo of Endometrial Stromal Cells

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1. scibot 06 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408481/
Jul 2025
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Mitotic slippage causes nuclear instability in polyploid cells

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  DOI: 10.1101/2025.07.21.665898
  
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biorxiv.org/content/10.1101/2025.07.21.665898v1
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A STAT3/integrin axis accelerates pancreatic cancer initiation and progression

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1-s2.0-S0016508525057324-main-html.html

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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
Jun 2025
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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
Mar 2025
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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  DOI: 10.1016/j.celrep.2025.115474
  
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Feb 2025
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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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  DOI: 10.1158/2159-8290.CD-21-1022
  
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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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sciencedirect.com/science/article/pii/S2211124725000439
Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

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  DOI: 10.1016/j.neuron.2024.11.006
  
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Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.cmet.2024.10.015
  
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sciencedirect.com/science/article/pii/S155041312400411X
Sep 2024
analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com

Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro

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  DOI: 10.1002/jat.4690
  
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analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.4690
Jun 2024
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Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells

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Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs

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SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells

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The outcome of tissue cryopreservation on cellular, molecular and epigenetic characteristics of endometrial tissue and stromal cells

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Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway

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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Sphingolipid metabolism controls mammalian heart regeneration

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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

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The interplay of TARG1 and PARG protects against genomic instability

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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Spatial epitope barcoding reveals clonal tumor patch behaviors

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Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis

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RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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Mucus sialylation determines intestinal host-commensal homeostasis

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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions

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GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility

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Quantitative control of noise in mammalian gene expression by dynamic histone regulation

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GCM2 Silencing in Parathyroid Adenoma is associated with Promoter Hypermethylation and Gain of Methylation on Histone 3

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation

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1. scibot 27 Jul 2021
  
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  RRID:AB_10231172
  
  DOI: 10.1016/j.molcel.2017.11.009
  
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SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

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  DOI: 10.1016/j.celrep.2021.109190
  
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Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum

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1. scibot 22 May 2021
  
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  DOI: 10.1016/j.neulet.2021.135978
  
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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

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1. scibot 21 May 2021
  
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  RRID:AB_823528
  
  DOI: 10.1016/j.molcel.2021.04.028
  
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Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment

1
1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.05.004
  
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Glutamine Metabolism Controls Chondrocyte Identity and Function

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  DOI: 10.1016/j.devcel.2020.05.001
  
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

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1. scibot 28 Apr 2021
  
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  RRID:AB_823528
  
  DOI: 10.1016/j.chembiol.2021.04.004
  
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Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production

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  DOI: 10.1016/j.chembiol.2020.08.006
  
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Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum

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  DOI: 10.1016/j.bbrc.2020.06.025
  
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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  DOI: 10.1016/j.chom.2021.03.001
  
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ER-directed TREX1 limits cGAS activation at micronuclei

1
1. scibot 01 Mar 2021
  
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

1
1. scibot 08 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108223
  
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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

1
1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.03.010
  
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823528
  
  DOI: 10.1016/j.molcel.2019.07.023
  
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BPS Publications

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  RRID:AB_823528
  
  DOI: 10.1111/bph.14837
  
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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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1. scibot 12 Jan 2020
  
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  RRID:AB_823528
  
  DOI: 10.1016/j.molcel.2018.09.031
  
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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

1
1. scibot 05 Nov 2018
  
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Untitled document

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BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

1
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Nov 2017
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Alterations in Histone Acetylases and Acetylated Histone Expression in Aging, Ethanol-Fed Rats

1
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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways

1
1. scibot 08 Nov 2017
  
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  AB_823528
  
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