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A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

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  DOI: 10.1016/j.isci.2026.117037
  
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Jul 2026
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Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life

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1. scibot 22 Jul 2026
  
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  DOI: 10.1038/s44318-026-00851-8
  
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Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0419
  
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aacrjournals.org/cancerres/article/85/18/3416/764453/Mitochondrial-Calcium-Uniporter-Links-Acetyl-CoA
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H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions

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Apr 2026
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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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Mar 2026
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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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Jan 2026
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A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages

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A CLOCK-targeting lncRNA induces trained immunity against tuberculosis

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sciencedirect.com/science/article/pii/S1931312825005219
Oct 2025
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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.drup.2025.101312
  
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SlWRKY14 integrates carotenoid and flavonoid biosynthetic pathways to regulate coloration and quality of tomato fruits

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Sep 2025
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Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate

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Regulatory Role for Tumor Suppressor REST on Estrogen Receptor (ESR1) Expression and Leiomyoma Pathophysiology

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  DOI: 10.1101/2025.08.29.673140
  
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biorxiv.org/content/10.1101/2025.08.29.673140v1
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Evaluating Endometrial Response to Human Chorionic Gonadotropin: Alterations in Epigenetic Regulation and Extracellular Vesicle Cargo of Endometrial Stromal Cells

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1. scibot 06 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408481/
Jul 2025
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Mitotic slippage causes nuclear instability in polyploid cells

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  DOI: 10.1101/2025.07.21.665898
  
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A STAT3/integrin axis accelerates pancreatic cancer initiation and progression

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1-s2.0-S0016508525057324-main-html.html

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  DOI: 10.1053/j.gastro.2025.07.003
  
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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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Jun 2025
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Mar 2025
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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Feb 2025
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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

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  DOI: 10.1016/j.neuron.2024.11.006
  
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Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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Sep 2024
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Epigenetic alternations in the SYP and DLG4 genes due to low-level methylmercury exposure during neuronal differentiation in vitro

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  DOI: 10.1002/jat.4690
  
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Jun 2024
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Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells

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May 2024
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Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs

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SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells

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Apr 2024
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The outcome of tissue cryopreservation on cellular, molecular and epigenetic characteristics of endometrial tissue and stromal cells

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  DOI: 10.1016/j.rbmo.2024.103990
  
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Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway

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Mar 2024
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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice

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  DOI: 10.1016/j.celrep.2024.113875
  
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Sphingolipid metabolism controls mammalian heart regeneration

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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

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Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence

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Jan 2023
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Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin

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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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Spatial epitope barcoding reveals clonal tumor patch behaviors

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Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis

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RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis

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Jun 2022
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cd-21-1022-html.html

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May 2022
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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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Mucus sialylation determines intestinal host-commensal homeostasis

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Dec 2021
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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions

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Sep 2021
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GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility

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Aug 2021
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Quantitative control of noise in mammalian gene expression by dynamic histone regulation

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Jul 2021
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GCM2 Silencing in Parathyroid Adenoma is associated with Promoter Hypermethylation and Gain of Methylation on Histone 3

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  DOI: 10.1210/clinem/dgab374
  
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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation

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Jun 2021
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SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

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May 2021
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Histone acetyltransferase EP300 regulates the proliferation and differentiation of neural stem cells during adult neurogenesis and regenerative neurogenesis in the zebrafish optic tectum

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  DOI: 10.1016/j.neulet.2021.135978
  
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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

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  DOI: 10.1016/j.molcel.2021.04.028
  
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Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment

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  DOI: 10.1016/j.molcel.2020.05.004
  
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Glutamine Metabolism Controls Chondrocyte Identity and Function

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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

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  DOI: 10.1016/j.chembiol.2021.04.004
  
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Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production

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Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum

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  DOI: 10.1016/j.bbrc.2020.06.025
  
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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  DOI: 10.1016/j.chom.2021.03.001
  
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ER-directed TREX1 limits cGAS activation at micronuclei

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  DOI: 10.1016/j.molcel.2020.12.037
  
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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  DOI: 10.1016/j.molcel.2019.07.023
  
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BPS Publications

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  DOI: 10.1111/bph.14837
  
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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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  DOI: 10.1016/j.molcel.2018.09.031
  
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Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

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Untitled document

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BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

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Nov 2017
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Alterations in Histone Acetylases and Acetylated Histone Expression in Aging, Ethanol-Fed Rats

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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways

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