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Combined Inhibition of HRAS and MEK Induces Tumor Regression and Restores Myogenic Differentiation in HRAS-Mutant Rhabdomyosarcoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13176821/
May 2026
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Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer

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  DOI: 10.64898/2026.04.16.719008
  
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biorxiv.org/content/10.64898/2026.04.16.719008v1
Apr 2026
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Functional analysis of rare RAS variants of unknown significance

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1. scibot 24 Apr 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0188
  
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aacrjournals.org/cancerrescommun/article/5/10/1747/766027/Functional-Analysis-of-Rare-RAS-Variants-of
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Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13080315/
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MAPK Pathway Mutations Emerge in Mutant IDH1 Inhibitor–Resistant Cholangiocarcinoma and Attenuate the IFN Response

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pmc.ncbi.nlm.nih.gov/articles/PMC13056288/
Mar 2026
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Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102704
  
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sciencedirect.com/science/article/pii/S2666379126001217
Feb 2026
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A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2

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  DOI: 10.1016/j.celrep.2026.116931
  
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sciencedirect.com/science/article/pii/S2211124726000094
Jul 2025
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BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

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pmc.ncbi.nlm.nih.gov/articles/PMC12272824/
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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1. scibot 16 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
Jun 2025
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EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC

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1. scibot 25 Jun 2025
  
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sciencedirect.com/science/article/pii/S2666379125002721
May 2025
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

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1. scibot 19 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
Mar 2025
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The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115365
  
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sciencedirect.com/science/article/pii/S2211124725001366
Jan 2025
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ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells

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  DOI: 10.1016/j.celrep.2024.115193
  
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sciencedirect.com/science/article/pii/S2211124724015444
Aug 2024
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Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

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1. scibot 02 Aug 2024
  
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  DOI: 10.3390/cells10123314
  
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mdpi.com/2073-4409/10/12/3314/htm
May 2024
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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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1. scibot 01 May 2024
  
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  DOI: 10.21203/rs.3.rs-4114038/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
Apr 2024
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A senescence restriction point acting on chromatin integrates oncogenic signals

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  DOI: 10.1016/j.celrep.2024.114044
  
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sciencedirect.com/science/article/pii/S2211124724003723
Aug 2023
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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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1. scibot 01 Aug 2023
  
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  DOI: 10.3390/ijms241411821
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
Jul 2023
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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  DOI: 10.1016/j.celrep.2023.112794
  
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sciencedirect.com/science/article/pii/S2211124723008057
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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sciencedirect.com/science/article/pii/S1097276523004306
Jun 2023
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Chemical genomics reveals targetable programs of human cancers rooted in pluripotency

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  DOI: 10.1016/j.chembiol.2023.06.004
  
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sciencedirect.com/science/article/pii/S2451945623001587
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KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2

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  DOI: 10.1016/j.isci.2023.106914
  
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sciencedirect.com/science/article/pii/S2589004223009914
May 2023
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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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1. scibot 05 May 2023
  
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  DOI: 10.1002/cac2.12332
  
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onlinelibrary.wiley.com/doi/10.1002/cac2.12332
Apr 2023
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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  DOI: 10.1016/j.ccell.2023.03.021
  
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sciencedirect.com/science/article/pii/S1535610823000946
www.embopress.org www.embopress.org

RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis

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  DOI: 10.15252/emmm.202217078
  
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embopress.org/doi/10.15252/emmm.202217078
Feb 2023
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Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

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  DOI: 10.1016/j.isci.2023.105962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
Jan 2023
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Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research

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  DOI: 10.4103/1673-5374.361516
  
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journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
Oct 2022
www.nature.com www.nature.com

Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

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1. scibot 08 Oct 2022
  
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  DOI: 10.1038/s41418-022-01072-2
  
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nature.com/articles/s41418-022-01072-2
May 2022
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A somatic mutation in moesin drives progression into acute myeloid leukemia

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  DOI: 10.1126/sciadv.abm9987
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9020775/
Apr 2022
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A somatic mutation in moesin drives progression into acute myeloid leukemia

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  DOI: 10.1126/sciadv.abm9987
  
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science.org/doi/full/10.1126/sciadv.abm9987
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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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  DOI: 10.1016/j.isci.2022.104211
  
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sciencedirect.com/science/article/pii/S2589004222004813
Jan 2022
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miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice

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  DOI: 10.1007/s13105-022-00871-y
  
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link.springer.com/article/10.1007/s13105-022-00871-y
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Acetylation-dependent regulation of BRAF oncogenic function

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  DOI: 10.1016/j.celrep.2021.110250
  
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sciencedirect.com/science/article/pii/S2211124721017629
Dec 2021
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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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1. scibot 03 Dec 2021
  
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  DOI: 10.1038/s42003-021-02842-3
  
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nature.com/articles/s42003-021-02842-3
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway

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1. scibot 14 Sep 2021
  
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  DOI: 10.3390/ijms22179580
  
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NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe

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Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer

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BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

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Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

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Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

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ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

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mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells

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Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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Phosphorylated Rasal2 facilitates breast cancer progression

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EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

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Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.

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Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

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Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model

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