52 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A senescence restriction point acting on chromatin integrates oncogenic signals
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    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114044

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    sciencedirect.com/science/article/pii/S2211124724003723
  3. Aug 2023
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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    1. scibot 01 Aug 2023
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      DOI: 10.3390/ijms241411821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  5. Jul 2023
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
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    Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
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    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.007

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    sciencedirect.com/science/article/pii/S1097276523004306
  8. Jun 2023
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    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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    1. scibot 28 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.06.004

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    sciencedirect.com/science/article/pii/S2451945623001587
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    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.isci.2023.106914

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    sciencedirect.com/science/article/pii/S2589004223009914
  11. May 2023
  12. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    1. scibot 05 May 2023
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      DOI: 10.1002/cac2.12332

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    onlinelibrary.wiley.com/doi/10.1002/cac2.12332
  13. Apr 2023
  14. www.sciencedirect.com www.sciencedirect.com
    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    1. scibot 21 Apr 2023
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    sciencedirect.com/science/article/pii/S1535610823000946
  15. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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    1. scibot 18 Apr 2023
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      DOI: 10.15252/emmm.202217078

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    embopress.org/doi/10.15252/emmm.202217078
  16. Feb 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105962

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  18. Jan 2023
  19. journals.lww.com journals.lww.com
    Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research
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    1. scibot 14 Jan 2023
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      DOI: 10.4103/1673-5374.361516

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    journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
  20. Oct 2022
  21. www.nature.com www.nature.com
    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
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    1. scibot 08 Oct 2022
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      DOI: 10.1038/s41418-022-01072-2

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    nature.com/articles/s41418-022-01072-2
  22. May 2022
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A somatic mutation in moesin drives progression into acute myeloid leukemia
    1
    1. scibot 11 May 2022
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      DOI: 10.1126/sciadv.abm9987

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    ncbi.nlm.nih.gov/pmc/articles/PMC9020775/
  24. Apr 2022
  25. www.science.org www.science.org
    A somatic mutation in moesin drives progression into acute myeloid leukemia
    1
    1. scibot 30 Apr 2022
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      DOI: 10.1126/sciadv.abm9987

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    science.org/doi/full/10.1126/sciadv.abm9987
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104211

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    sciencedirect.com/science/article/pii/S2589004222004813
  27. Jan 2022
  28. link.springer.com link.springer.com
    miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice
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    1. scibot 28 Jan 2022
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      DOI: 10.1007/s13105-022-00871-y

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    link.springer.com/article/10.1007/s13105-022-00871-y
  29. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110250

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    sciencedirect.com/science/article/pii/S2211124721017629
  30. Dec 2021
  31. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    1. scibot 03 Dec 2021
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      DOI: 10.1038/s42003-021-02842-3

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    nature.com/articles/s42003-021-02842-3
  32. Sep 2021
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
    1
    1. scibot 14 Sep 2021
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      DOI: 10.3390/ijms22179580

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    ncbi.nlm.nih.gov/pmc/articles/PMC8431595/
  34. Aug 2021
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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    1. scibot 21 Aug 2021
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      DOI: 10.7554/eLife.64846

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    ncbi.nlm.nih.gov/pmc/articles/PMC8370767/
  36. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 08 Aug 2021
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      DOI: 10.1016/j.celrep.2018.10.049

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    sciencedirect.com/science/article/pii/S2211124718316383
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1111/jnc.14537

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14537
  38. www.jbc.org www.jbc.org
    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
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      DOI: 10.1074/jbc.RA118.005231

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    jbc.org/content/294/6/1763.full
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.stem.2018.05.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC5988582/
  40. Jul 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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      DOI: 10.1016/j.ccell.2018.10.003

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    sciencedirect.com/science/article/pii/S1535610818304690
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
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      DOI: 10.1016/j.celrep.2018.10.049

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    ncbi.nlm.nih.gov/pmc/articles/PMC6261462/
  43. www.sciencedirect.com www.sciencedirect.com
    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer
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      DOI: 10.1016/j.ebiom.2019.05.008

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    sciencedirect.com/science/article/pii/S2352396419303093
  44. Jun 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
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      DOI: 10.1016/j.celrep.2021.109233

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    sciencedirect.com/science/article/pii/S2211124721005921
  46. May 2021
  47. www.sciencedirect.com www.sciencedirect.com
    ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
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      DOI: 10.1016/j.devcel.2020.05.011

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    sciencedirect.com/science/article/pii/S1534580720304007
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    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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      DOI: 10.1016/j.celrep.2021.109069

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    sciencedirect.com/science/article/pii/S2211124721004009
  49. Apr 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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      DOI: 10.1016/j.cell.2021.03.031

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    sciencedirect.com/science/article/pii/S0092867421003627
  51. www.nature.com www.nature.com
    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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      DOI: 10.1038/s41556-021-00654-5

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    nature.com/articles/s41556-021-00654-5
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    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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      DOI: 10.1016/j.celrep.2021.108928

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    sciencedirect.com/science/article/pii/S2211124721002424
  53. Oct 2020
  54. www.sciencedirect.com www.sciencedirect.com
    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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      DOI: 10.1016/j.cell.2020.09.002

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    sciencedirect.com/science/article/pii/S0092867420311430
  55. Sep 2020
  56. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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      DOI: 10.1016/j.cmet.2020.04.011

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    sciencedirect.com/science/article/pii/S1550413120301935
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    Dynamic Regulation of Mitochondrial Import by the Ubiquitin System
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      DOI: 10.1016/j.molcel.2020.02.012

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    sciencedirect.com/science/article/pii/S1097276520301052
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
  59. academic.oup.com academic.oup.com
    Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells
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      DOI: 10.1210/jendso/bvz029

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    academic.oup.com/jes/article/4/2/bvz029/5671714
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    Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
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      DOI: 10.1016/j.cell.2020.04.014

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    sciencedirect.com/science/article/pii/S0092867420304761
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  62. Jan 2020
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    Phosphorylated Rasal2 facilitates breast cancer progression
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    EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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      DOI: 10.1016/j.cell.2019.01.002

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  70. Nov 2018
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    An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
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    Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.
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  74. Nov 2017
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    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
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    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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