214 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Plausible, robust biological oscillations through allelic buffering
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    1. scibot 15 Nov 2024
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    sciencedirect.com/science/article/pii/S2405471224002990
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    sciencedirect.com/science/article/pii/S1097276524008633
  4. Oct 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids
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    1. scibot 08 Oct 2024
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      DOI: 10.1091/mbc.E24-04-0166

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321050/
  6. Sep 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Metformin decelerates aging clock in male monkeys
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    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S0092867424009140
  8. Aug 2024
  9. www.sciencedirect.com www.sciencedirect.com
    On the role of p53 in the cellular response to aneuploidy
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    1. scibot 29 Aug 2024
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      DOI: 10.1016/j.celrep.2021.108892

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    sciencedirect.com/science/article/pii/S2211124721002060
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys
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    1. scibot 22 Aug 2024
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      DOI: 10.1038/s41420-024-02131-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11324798/
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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    sciencedirect.com/science/article/pii/S2211124724009604
  12. www.cell.com www.cell.com
    Activated dormant stem cells recover spermatogenesis in chemoradiotherapy-induced infertility
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    1. scibot 18 Aug 2024
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    cell.com/cell-reports/fulltext/S2211-1247(24)00911-2
  13. academic.oup.com academic.oup.com
    Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids
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      DOI: 10.1093/molehr/gaac039

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    academic.oup.com/molehr/article/28/12/gaac039/6825317
  14. www.mdpi.com www.mdpi.com
    A Novel Monoclonal Antibody Targeting Cancer-Specific Plectin Has Potent Antitumor Activity in Ovarian Cancer
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    1. scibot 02 Aug 2024
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    mdpi.com/2073-4409/10/9/2218/htm
  15. Jul 2024
  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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    1. scibot 23 Jul 2024
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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
  17. www.nature.com www.nature.com
    Table 1 Antibody table.
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    1. scibot 19 Jul 2024
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    nature.com/articles/s41420-024-02048-6/tables/1
  18. Jun 2024
  19. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
    1
    1. scibot 30 Jun 2024
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
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    Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
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    sciencedirect.com/science/article/pii/S1534580724002958
  21. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
    2
    1. scibot 06 Jun 2024
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      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  22. May 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells
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    1. scibot 30 May 2024
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      DOI: 10.1101/2024.05.08.593217

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    ncbi.nlm.nih.gov/pmc/articles/PMC11100710/
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    A novel Senescence-Based prognostic model unveils tumor interactions and drug resistance in colorectal cancer
    1
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    sciencedirect.com/science/article/pii/S156757692400715X
  25. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
    2
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    52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
    1
    1. scibot 10 May 2024
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      DOI: 10.1016/j.xcrm.2024.101552

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    sciencedirect.com/science/article/pii/S2666379124002441
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
    1
    1. scibot 09 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068553/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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      DOI: 10.1016/j.isci.2024.109693

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    ncbi.nlm.nih.gov/pmc/articles/PMC11059122/
  29. www.science.org www.science.org
    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
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      DOI: 10.1126/science.adi2421

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    science.org/doi/10.1126/science.adi2421
  30. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
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      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  31. Apr 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies
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      DOI: 10.1016/j.isci.2024.109640

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    ncbi.nlm.nih.gov/pmc/articles/PMC11053310/
  33. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
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    1. scibot 25 Apr 2024
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      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  34. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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      DOI: 10.1016/j.devcel.2024.03.032

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    sciencedirect.com/science/article/pii/S1534580724002004
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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      DOI: 10.21037/tlcr-24-160

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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10985479/
  37. Mar 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    sciencedirect.com/science/article/pii/S2666379124001149
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S0304416524000436
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    sciencedirect.com/science/article/pii/S1534580724001072
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    sciencedirect.com/science/article/pii/S1097276524001291
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    AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway
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    sciencedirect.com/science/article/pii/S0925443924001054
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    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
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    sciencedirect.com/science/article/pii/S2589004224004528
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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  45. Feb 2024
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  52. Jan 2024
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    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    SARS-CoV-2 infection causes dopaminergic neuron senescence
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  56. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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    Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
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    VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis
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  63. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  73. Oct 2023
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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  78. Sep 2023
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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
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  87. Jul 2023
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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  92. Jun 2023
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  102. Mar 2023
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  107. Jan 2023
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  110. Nov 2022
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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  134. Apr 2022
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  147. Nov 2021
  148. 52.53.155.43 52.53.155.43
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    RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
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  150. Oct 2021
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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  152. Sep 2021
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    CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
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  155. Aug 2021
  156. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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  162. Jul 2021
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
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    Loganetin protects against rhabdomyolysis‐induced acute kidney injury by modulating the toll‐like receptor 4 signalling pathway
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    MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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  178. May 2021
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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  182. Apr 2021
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    Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-β Signaling
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    Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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    The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21
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    PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells
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    Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
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