258 Matching Annotations
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    Pharmacologic interrogation of USP28 cellular function in p53 signaling
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  3. Aug 2025
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    A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
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    Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
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    Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against minichromosome maintenance complex reloading and tetraploidy
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    Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer
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    Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging
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  11. Jun 2025
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    Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation
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    Senescence-resistant human mesenchymal progenitor cells counter aging in primates
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
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    Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming
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    Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition
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  19. May 2025
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    IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma
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    CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication
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    Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells
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  25. Apr 2025
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    Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression
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    Preparation for mitosis requires gradual CDK1 activation
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    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
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  33. Feb 2025
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  38. Jan 2025
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    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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  53. Nov 2024
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  57. Oct 2024
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  59. Sep 2024
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  61. Aug 2024
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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  68. Jul 2024
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  71. Jun 2024
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  75. May 2024
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    A novel Senescence-Based prognostic model unveils tumor interactions and drug resistance in colorectal cancer
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    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
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    Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
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    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
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    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  84. Apr 2024
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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  90. Mar 2024
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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  98. Feb 2024
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
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    MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
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  227. Jun 2021
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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  231. May 2021
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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  235. Apr 2021
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