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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    sciencedirect.com/science/article/pii/S1534580724002004
  3. Apr 2024
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    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
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    AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer
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  6. Mar 2024
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    sciencedirect.com/science/article/pii/S2666379124001149
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    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S0304416524000436
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    sciencedirect.com/science/article/pii/S1097276524001291
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    AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway
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    sciencedirect.com/science/article/pii/S0925443924001054
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    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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  14. Feb 2024
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    Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model
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    sciencedirect.com/science/article/pii/S0925443924000425
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    BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
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    biorxiv.org/content/10.1101/2023.09.28.560054v1
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  21. Jan 2024
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    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
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    SARS-CoV-2 infection causes dopaminergic neuron senescence
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    sciencedirect.com/science/article/pii/S1934590923004423
  25. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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    Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
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    sciencedirect.com/science/article/pii/S2352396423005066
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124723015760
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    Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling
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    sciencedirect.com/science/article/pii/S1534580723006184
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    VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis
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  32. Nov 2023
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    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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    sciencedirect.com/science/article/abs/pii/S2451945623003720
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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    Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202301292R
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
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    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  42. Oct 2023
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
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      DOI: 10.1158/0008-5472.CAN-22-1337

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  47. Sep 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESRRB inhibits the TGF-β signaling pathway to drive cell proliferation in cervical cancer
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    C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
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  51. Aug 2023
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    Nuclear transport surveillance of p53 by nuclear pores in glioblastoma
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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
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  56. Jul 2023
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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  61. Jun 2023
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    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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  63. May 2023
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    miR‐17‐3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition
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  65. Apr 2023
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    UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer
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    Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential
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    DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites
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  71. Mar 2023
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  74. Feb 2023
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    Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia
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  76. Jan 2023
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    Anlotinib Suppressed Ovarian Cancer Progression via Inducing G2/M Phase Arrest and Apoptosis
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  79. Nov 2022
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    Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
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  83. Oct 2022
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    Centromere protein J is overexpressed in human glioblastoma and promotes cell proliferation and migration
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    Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance
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    Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response
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  96. Jun 2022
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  103. Apr 2022
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  116. Nov 2021
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    RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
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  119. Oct 2021
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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  121. Sep 2021
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    CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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  124. Aug 2021
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
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    Loganetin protects against rhabdomyolysis‐induced acute kidney injury by modulating the toll‐like receptor 4 signalling pathway
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    MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    Bacterial genotoxins induce T cell senescence
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    Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis
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    Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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    The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21
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      DOI: 10.1016/j.celrep.2019.04.101

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      DOI: 10.1016/j.celrep.2019.02.047

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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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      DOI: 10.1038/s41408-018-0165-5

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    PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells
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      DOI: 10.1016/j.celrep.2019.03.031

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    Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
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      DOI: 10.1016/j.molcel.2018.10.011

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  202. Nov 2018
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
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    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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    Intrinsic Immunity Shapes Viral Resistance of Stem Cells
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  209. Nov 2017
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    Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug
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    Metabolic Adaptation Establishes Disease Tolerance to Sepsis
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    TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence
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    Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2
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    Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a
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    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC5241115/
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    Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC4141641