65 Matching Annotations
  1. Oct 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
    1
    1. scibot 04 Oct 2024
      RRID:AB_823629

      DOI: 10.1158/1535-7163.MCT-23-0564

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.013

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    sciencedirect.com/science/article/pii/S0092867424009048
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  7. Jul 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
    1
    1. scibot 31 Jul 2024
      RRID: AB_823629

      DOI: 10.1158/2767-9764.CRC-24-0247

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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
  9. www.cell.com www.cell.com
    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.chembiol.2024.06.012

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    cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00273-3
  10. May 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.ccell.2024.05.002

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    sciencedirect.com/science/article/pii/S1535610824001636
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular and pathological characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies
    1
    1. scibot 03 May 2024
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      DOI: 10.1158/1078-0432.CCR-23-2360

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    ncbi.nlm.nih.gov/pmc/articles/PMC11061608/
  13. Apr 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.113924

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    ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
  15. Mar 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
    2
    1. scibot 21 Mar 2024
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    2. scibot 21 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113924

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    ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
  17. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    2. scibot 08 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1158/2159-8290.CD-23-0954

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  19. Feb 2024
  20. 52.53.155.43 52.53.155.43
    d1-html.html
    1
    1. scibot 29 Feb 2024
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    52.53.155.43/9d9c84a50a37d03d2f105a9516b773f31c793012/d1-html.html
  21. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
    1
    1. scibot 27 Feb 2024
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    52.53.155.43/aaf525c30ae01b53e260240fad732783dfb4bbac/cd-23-0954-html.html
  22. Nov 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.017

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    sciencedirect.com/science/article/pii/S1097276523008547
  24. www.sciencedirect.com www.sciencedirect.com
    p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113486

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    sciencedirect.com/science/article/pii/S2211124723014985
  25. Oct 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
      RRID:AB_823629

      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer
    1
    1. scibot 06 Oct 2023
      RRID:AB_823629

      DOI: 10.1158/0008-5472.CAN-22-3484

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    ncbi.nlm.nih.gov/pmc/articles/PMC10543968/
  28. Sep 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
    1
    1. scibot 30 Sep 2023
      RRID:AB_823629

      DOI: 10.1016/j.devcel.2023.08.028

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    sciencedirect.com/science/article/pii/S1534580723004434
  30. Aug 2023
  31. www.sciencedirect.com www.sciencedirect.com
    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
    1
    1. scibot 03 Aug 2023
      RRID:AB_823629

      DOI: 10.1016/j.celrep.2023.112886

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    sciencedirect.com/science/article/pii/S2211124723008975
  32. Jun 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
    1
    1. scibot 30 Jun 2023
      RRID:AB_823629

      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
  34. www.sciencedirect.com www.sciencedirect.com
    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
    1
    1. scibot 02 Jun 2023
      RRID:AB_823629

      DOI: 10.1016/j.cell.2023.05.013

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    sciencedirect.com/science/article/pii/S0092867423005329
  35. 52.53.155.43 52.53.155.43
    can-22-3484-html.html
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1158/0008-5472.CAN-22-3484

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    52.53.155.43/78582fc87eae4b7ad3ee30a95dff40dcb4611547/can-22-3484-html.html
  36. May 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Modeling breast cancer proliferation, drug synergies, and alternating therapies
    1
    1. scibot 19 May 2023
      RRID:AB_823629

      DOI: 10.1016/j.isci.2023.106714

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    sciencedirect.com/science/article/pii/S2589004223007915
  38. aacrjournals.org aacrjournals.org
    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
    1
    1. scibot 05 May 2023
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      DOI: 10.1158/0008-5472.CAN-22-0410

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    aacrjournals.org/cancerres/article/82/13/2458/705024/Transcriptional-Repression-by-FoxM1-Suppresses
  39. Apr 2023
  40. www.sciencedirect.com www.sciencedirect.com
    UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer
    1
    1. scibot 26 Apr 2023
      RRID:AB_823629

      DOI: 10.1016/j.celrep.2023.112423

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    sciencedirect.com/science/article/pii/S2211124723004345
  41. www.thelancet.com www.thelancet.com
    Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers
    2
    1. scibot 20 Apr 2023
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      DOI: 10.1016/j.ebiom.2023.104577

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      DOI: 10.1016/j.ebiom.2023.104577

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    thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00142-1/abstract
  42. Mar 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
    1
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112252

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    sciencedirect.com/science/article/pii/S2211124723002632
  44. Oct 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
    1
    1. scibot 04 Oct 2022
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      DOI: 10.1016/j.medj.2022.09.002

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    sciencedirect.com/science/article/pii/S2666634022004032
  46. Aug 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
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    1. scibot 23 Aug 2022
      RRID:AB_10696874

      DOI: 10.1016/j.molcel.2022.07.014

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    sciencedirect.com/science/article/pii/S1097276522007109
  48. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance
    1
    1. scibot 10 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111177

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    sciencedirect.com/science/article/pii/S2211124722009901
  49. www.sciencedirect.com www.sciencedirect.com
    The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells
    1
    1. scibot 10 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111170

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    sciencedirect.com/science/article/pii/S2211124722009834
  50. Mar 2022
  51. www.nature.com www.nature.com
    Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
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      DOI: 10.1038/s41467-022-28515-1

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    nature.com/articles/s41467-022-28515-1
  52. www.sciencedirect.com www.sciencedirect.com
    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
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      DOI: 10.1016/j.celrep.2022.110448

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    sciencedirect.com/science/article/pii/S2211124722001759
  53. Dec 2021
  54. www.nature.com www.nature.com
    KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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    1. scibot 18 Dec 2021
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      DOI: 10.1038/s41467-021-27502-2

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    nature.com/articles/s41467-021-27502-2
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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    1. scibot 17 Dec 2021
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      DOI: 10.7554/eLife.70691

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    ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
    1
    1. scibot 11 Dec 2021
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      DOI: 10.3389/fcell.2021.773048

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    ncbi.nlm.nih.gov/pmc/articles/PMC8652204/
  57. Nov 2021
  58. 52.53.155.43 52.53.155.43
    ajpheart.00125.2021-html.html
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      DOI: 10.1152/ajpheart.00125.2021

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    52.53.155.43/97c82e9b6b3864243bc7b06ebc69cb131650363f/ajpheart.00125.2021-html.html
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence
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  60. Jul 2021
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      AB_823629

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    Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
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      DOI: 10.1016/j.ccell.2018.05.014

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  63. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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  64. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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  66. Apr 2021
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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  69. www.cell.com www.cell.com
    Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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  71. Sep 2020
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    Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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      DOI: 10.1016/j.molcel.2019.12.022

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  77. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      RB1

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  78. Jan 2020
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    Generation of two H1 hESC sublines carrying deletions of RB1 exon 1/promoter in heterozygous or compound heterozygous state
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      RRID:AB_823629

      DOI: 10.1016/j.scr.2019.101517

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    Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
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      RRID:AB_823629

      DOI: 10.1016/j.chembiol.2019.05.005

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    sciencedirect.com/science/article/pii/S2451945619301746
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    Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
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    1. scibot 13 Jan 2020
      RRID:AB_823629

      DOI: 10.1016/j.molcel.2019.08.020

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    sciencedirect.com/science/article/pii/S1097276519306598
  82. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_823629

      DOI: 10.1016/j.chembiol.2019.02.015

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    sciencedirect.com/science/article/pii/S2451945619300704
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    MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance
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      RRID:AB_823629

      DOI: 10.1016/j.celrep.2019.02.023

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    sciencedirect.com/science/article/pii/S2211124719301937
  84. Nov 2018
  85. www.sciencedirect.com www.sciencedirect.com
    Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
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      RRID:AB_823629

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    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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  87. Nov 2017
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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      AB_823629

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