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54.241.53.176 54.241.53.176

1-s2.0-S2589004226009855-main-html.html

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.isci.2026.115610
  
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54.241.53.176/05f2ee76cf34c035d0dc3049b70cb46affdee9c3/1-s2.0-S2589004226009855-main-html.html
aacrjournals.org aacrjournals.org

Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer

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1. scibot 07 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-24-0903
  
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aacrjournals.org/mct/article/24/12/1959/768323/Harnessing-Senolytics-and-PARP-Inhibition-to
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Differential contribution of TFE3 isoforms to cell motility and invasion

1
1. scibot 31 Jan 2026
  
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  DOI: 10.1038/s44319-025-00659-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852735/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

1
1. scibot 30 Jan 2026
  
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  DOI: 10.1038/s41419-025-08362-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
www.nature.com www.nature.com

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

1
1. scibot 27 Jan 2026
  
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  DOI: 10.1038/s41467-025-67865-4
  
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nature.com/articles/s41467-025-67865-4
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

1
1. scibot 26 Jan 2026
  
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  RRID:AB_823629
  
  DOI: 10.7554/eLife.104545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12747521/
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CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia

1
1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102526
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12866115/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

CDK4/6 inhibition reprograms the breast cancer immunopeptidome via Rb-dependent chromatin and transcriptomic remodeling

1
1. scibot 16 Dec 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.celrep.2025.116676
  
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sciencedirect.com:5037/science/article/pii/S2211124725014482
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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

2
1. scibot 06 Dec 2025
  
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  DOI: 10.1038/s41523-025-00851-7
  
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2. scibot 06 Dec 2025
  
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  DOI: 10.1038/s41523-025-00851-7
  
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nature.com/articles/s41523-025-00851-7
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer

1
1. scibot 20 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2492
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12625700/
Oct 2025
www.biorxiv.org www.biorxiv.org

Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherin

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1. scibot 23 Oct 2025
  
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  DOI: 10.1101/2025.10.16.682706
  
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biorxiv.org/content/10.1101/2025.10.16.682706v1
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CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

1
1. scibot 21 Oct 2025
  
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  RRID:AB_823629
  
  DOI: 10.1101/2025.10.14.681840
  
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biorxiv.org/content/10.1101/2025.10.14.681840v1
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Design of multi-target peptide modulators for protein chaperone networks

1
1. scibot 26 Aug 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.str.2025.07.021
  
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sciencedirect.com/science/article/pii/S0969212625002692
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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

1
1. scibot 26 Aug 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.molcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S109727652500646X
Jun 2025
www.nature.com www.nature.com

PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer

1
1. scibot 18 Jun 2025
  
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  RRID: AB_823629
  
  DOI: 10.1038/s41388-025-03468-z
  
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nature.com/articles/s41388-025-03468-z
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

1
1. scibot 04 Jun 2025
  
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  RRID:AB_823629
  
  DOI: 10.1186/s12885-025-14361-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

1
1. scibot 20 May 2025
  
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  RRID:AB_823629
  
  DOI: 10.1158/1078-0432.CCR-24-1238
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11530313/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

1
1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.006
  
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sciencedirect.com/science/article/pii/S2451945625000960
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

1-s2.0-S2589004225006248-main-html.html

1
1. scibot 10 Apr 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.isci.2025.112363
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12053632/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors

1
1. scibot 05 Apr 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2360
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
Mar 2025
www.sciencedirect.com www.sciencedirect.com

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

1
1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network

1
1. scibot 07 Mar 2025
  
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  RRID:AB_823629
  
  DOI: 10.1126/sciadv.adr9660
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870056/
www.science.org www.science.org

TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network

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1. scibot 05 Mar 2025
  
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  RRID:AB_823629
  
  DOI: 10.1126/sciadv.adr9660
  
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science.org/doi/10.1126/sciadv.adr9660
Feb 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

1
1. scibot 27 Feb 2025
  
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  RRID:AB_823629
  
  DOI: 10.1101/2025.01.21.25320683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
Jan 2025
www.sciencedirect.com www.sciencedirect.com

The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

1
1. scibot 28 Jan 2025
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.xcrm.2025.101929
  
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sciencedirect.com/science/article/pii/S2666379125000023
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

1
1. scibot 25 Jan 2025
  
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  RRID:AB_823629
  
  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
Dec 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer

2
1. scibot 13 Dec 2024
  
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  9309, CST
  
  DOI: 10.1002/jmv.70088
  
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2. scibot 13 Dec 2024
  
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  9309
  
  DOI: 10.1002/jmv.70088
  
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onlinelibrary.wiley.com/doi/full/10.1002/jmv.70088
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer

1
1. scibot 04 Oct 2024
  
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  RRID:AB_823629
  
  DOI: 10.1158/1535-7163.MCT-23-0564
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

1
1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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1. scibot 02 Aug 2024
  
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  DOI: 10.1038/s41408-021-00603-3
  
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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

1
1. scibot 31 Jul 2024
  
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  RRID: AB_823629
  
  DOI: 10.1158/2767-9764.CRC-24-0247
  
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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
www.cell.com www.cell.com

A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer

1
1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.chembiol.2024.06.012
  
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Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators

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Molecular and pathological characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies

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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors

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d1-html.html

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cd-23-0954-html.html

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP

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Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer

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Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer

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Palbociclib releases the latent differentiation capacity of neuroblastoma cells

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FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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can-22-3484-html.html

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Modeling breast cancer proliferation, drug synergies, and alternating therapies

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Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer

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UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer

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Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers

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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

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The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

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Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

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Nov 2021
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ajpheart.00125.2021-html.html

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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence

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Jul 2021
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  AB_823629
  
  DOI: 10.1016/j.chembiol.2018.11.006
  
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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

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  RRID:AB_823629
  
  DOI: 10.1016/j.ccell.2018.05.014
  
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CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells

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  9309T
  
  DOI: 10.1016/j.virol.2021.07.005
  
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sciencedirect.com/science/article/pii/S0042682221001525
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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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  DOI: 10.1016/j.devcel.2021.04.030
  
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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  DOI: 10.1016/j.stem.2021.03.005
  
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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  DOI: 10.1016/j.cell.2020.10.023
  
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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

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  DOI: 10.1016/j.ccell.2020.12.014
  
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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

2
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  DOI: 10.1016/j.celrep.2021.108944
  
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  DOI: 10.1016/j.celrep.2021.108944
  
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Sep 2020
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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

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  DOI: 10.1016/j.celrep.2020.108181
  
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Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

1
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  DOI: 10.1016/j.celrep.2020.107669
  
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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  RRID:AB_823629
  
  DOI: 10.7554/eLife.56913
  
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

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  DOI: 10.1016/j.molcel.2019.12.022
  
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clincancerres.aacrjournals.org clincancerres.aacrjournals.org

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

1
1. scibot 03 Sep 2020
  
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  RB1
  
  DOI: 10.1158/1078-0432.CCR-19-2706
  
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clincancerres.aacrjournals.org/content/26/12/2997
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Generation of two H1 hESC sublines carrying deletions of RB1 exon 1/promoter in heterozygous or compound heterozygous state

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  RRID:AB_823629
  
  DOI: 10.1016/j.scr.2019.101517
  
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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

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  RRID:AB_823629
  
  DOI: 10.1016/j.molcel.2019.08.020
  
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Untitled document

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  RRID:AB_823629
  
  DOI: 10.1016/j.chembiol.2019.02.015
  
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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

1
1. scibot 12 Jan 2020
  
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  RRID:AB_823629
  
  DOI: 10.1016/j.celrep.2019.02.023
  
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sciencedirect.com/science/article/pii/S2211124719301937
Nov 2018
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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

1
1. scibot 05 Nov 2018
  
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Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

1
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Nov 2017
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

1
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

1
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  AB_823629
  
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sciencedirect.com/science/article/pii/S2405471216304082

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