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103 Matching Annotations

Aug 2026
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CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication

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1. scibot 28 Aug 2026
  
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IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states

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CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo

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  DOI: 10.1016/j.xcrm.2026.103004
  
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Jul 2026
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A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells

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May 2026
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CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver

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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer

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  DOI: 10.1007/s10495-026-02340-z
  
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Apr 2026
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p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1–driven ovarian cancers

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1-s2.0-S2589004226009855-main-html.html

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Harnessing senolytics and PARP inhibition to expand the antitumor activity of CDK4/6 inhibitors in prostate cancer

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  DOI: 10.1158/1535-7163.MCT-24-0903
  
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aacrjournals.org/mct/article/24/12/1959/768323/Harnessing-Senolytics-and-PARP-Inhibition-to
Jan 2026
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Differential contribution of TFE3 isoforms to cell motility and invasion

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Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

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CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

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Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

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  DOI: 10.7554/eLife.104545
  
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CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia

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  DOI: 10.1016/j.xcrm.2025.102526
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12866115/
Dec 2025
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CDK4/6 inhibition reprograms the breast cancer immunopeptidome via Rb-dependent chromatin and transcriptomic remodeling

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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  DOI: 10.1038/s41523-025-00851-7
  
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Nov 2025
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Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer

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1. scibot 20 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2492
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12625700/
Oct 2025
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Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherin

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  DOI: 10.1101/2025.10.16.682706
  
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CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

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  DOI: 10.1101/2025.10.14.681840
  
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biorxiv.org/content/10.1101/2025.10.14.681840v1
Aug 2025
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Design of multi-target peptide modulators for protein chaperone networks

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A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

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  DOI: 10.1016/j.molcel.2025.07.023
  
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Jun 2025
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PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer

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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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  DOI: 10.1016/j.redox.2025.103649
  
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Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
May 2025
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Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities

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  DOI: 10.1158/1078-0432.CCR-24-1238
  
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Apr 2025
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CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

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  DOI: 10.1016/j.chembiol.2025.03.006
  
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1-s2.0-S2589004225006248-main-html.html

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  DOI: 10.1016/j.isci.2025.112363
  
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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC11967718/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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sciencedirect.com/science/article/pii/S1535610825000583
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TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network

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  DOI: 10.1126/sciadv.adr9660
  
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TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network

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  DOI: 10.1126/sciadv.adr9660
  
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science.org/doi/10.1126/sciadv.adr9660
Feb 2025
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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

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  DOI: 10.1101/2025.01.21.25320683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
Jan 2025
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The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

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  DOI: 10.1016/j.xcrm.2025.101929
  
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer

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Oct 2024
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PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer

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Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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Jul 2024
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer

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May 2024
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Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators

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Molecular and pathological characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies

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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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Mar 2024
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors

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Feb 2024
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d1-html.html

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cd-23-0954-html.html

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP

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Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer

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Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer

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Palbociclib releases the latent differentiation capacity of neuroblastoma cells

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FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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can-22-3484-html.html

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Modeling breast cancer proliferation, drug synergies, and alternating therapies

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Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer

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Apr 2023
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UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer

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Microwave hyperthermia represses human papillomavirus oncoprotein activity and induces cell death due to cell stress in 3D tissue models of anogenital precancers and cancers

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Mar 2023
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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

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The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

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Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

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ajpheart.00125.2021-html.html

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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence

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Untitled document

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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

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CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells

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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

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Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

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  DOI: 10.1016/j.molcel.2019.12.022
  
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clincancerres.aacrjournals.org clincancerres.aacrjournals.org

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

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  RB1
  
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Generation of two H1 hESC sublines carrying deletions of RB1 exon 1/promoter in heterozygous or compound heterozygous state

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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

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Untitled document

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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

1
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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

1
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Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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