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IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors

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Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

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sciencedirect.com/science/article/pii/S1097276526002662
Apr 2026
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Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment

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1. scibot 09 Apr 2026
  
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sciencedirect.com/science/article/pii/S1074761326001226
Mar 2026
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1-s2.0-S2589004226008801-main-html.html

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1. scibot 27 Mar 2026
  
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54.241.53.176/fe113be5e0479b752456981d23467ff50eff5555/1-s2.0-S2589004226008801-main-html.html
Jul 2025
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Brain miR-137 governs growth and development via GH/IGF-1 signaling

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bmcbiol.biomedcentral.com/articles/10.1186/s12915-025-02306-8
Jun 2025
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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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sciencedirect.com/science/article/pii/S1074761325002274
May 2025
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PIM kinase control of CD8 T cell protein synthesis and cell trafficking

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.98622
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074636/
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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

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pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
Apr 2025
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Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity

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pmc.ncbi.nlm.nih.gov/articles/PMC11997551/
Sep 2024
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CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway

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1. scibot 26 Sep 2024
  
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sciencedirect.com/science/article/pii/S2666979X24002702
May 2024
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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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1. scibot 09 May 2024
  
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  DOI: 10.1210/endocr/bqae039
  
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52.53.155.43 52.53.155.43

bqae039-html.html

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  DOI: 10.6084/m9.figshare.24398467.v2
  
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52.53.155.43/ab567994747ba987c62f3a62774a1442bfaf3557/bqae039 (1)-html.html
Dec 2023
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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108597
  
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sciencedirect.com/science/article/pii/S2589004223026743
Aug 2023
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Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

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  DOI: 10.1158/2159-8290.CD-22-1396
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10401075/
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Hedgehog receptors exert immune-surveillance roles in the epidermis across species

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1. scibot 03 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112929
  
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sciencedirect.com/science/article/pii/S2211124723009403
Dec 2022
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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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1. scibot 02 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105528
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9708799/
Jul 2022
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Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma

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1. scibot 12 Jul 2022
  
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  DOI: 10.1002/ctm2.939
  
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onlinelibrary.wiley.com/doi/10.1002/ctm2.939
May 2022
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Dietary supplementation with lysine (protein) stimulates mammary development in late-pregnant gilts

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1. scibot 18 May 2022
  
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  DOI: 10.1093/jas/skac051
  
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academic.oup.com/jas/article/100/5/skac051/6532658
Feb 2022
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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification

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ncbi.nlm.nih.gov/pmc/articles/PMC8797172/
Oct 2021
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Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

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1. scibot 08 Oct 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8490354/
Aug 2021
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Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells

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sciencedirect.com/science/article/pii/S2211124721009372
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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6370974/
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Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

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sciencedirect.com/science/article/pii/S221112471931352X
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NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland

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academic.oup.com/endo/article/160/8/1797/5488072
Jul 2021
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.067
  
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sciencedirect.com/science/article/pii/S2211124719300968
Jun 2021
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A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells

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  DOI: 10.1016/j.cell.2021.05.028
  
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sciencedirect.com/science/article/pii/S0092867421006589
May 2021
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Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development

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1. scibot 12 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109096
  
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sciencedirect.com/science/article/pii/S2211124721004307
Apr 2021
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

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sciencedirect.com/science/article/pii/S1535610820305419
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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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1. scibot 14 Apr 2021
  
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  Anti-phospho-STAT5 Y694 (C11C5)
  
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sciencedirect.com/science/article/pii/S1074761321001205
Mar 2021
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Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus

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1. scibot 24 Mar 2021
  
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  DOI: 10.3389/fimmu.2021.635531
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7982885/
Sep 2020
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Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function

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pmc.ncbi.nlm.nih.gov/articles/PMC7398039/
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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies

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1. scibot 03 Sep 2020
  
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  DOI: 10.1111/bph.14809
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14809
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A Neuro-hormonal Circuit for Paternal Behavior Controlled by a Hypothalamic Network Oscillation

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.07.007
  
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sciencedirect.com/science/article/pii/S0092867420308722
Jan 2020
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Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

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1. scibot 13 Jan 2020
  
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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

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Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

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Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response

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Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

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