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TCR-NF-κB signaling activates the SENP1-NR4A1 axis to fine-tune effector activation of CD8+ T cells

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117102
  
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sciencedirect.com/science/article/pii/S2211124726001804
Feb 2026
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Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation

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  DOI: 10.1016/j.immuni.2026.01.003
  
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Jan 2026
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Depletion of myeloid cells in AG129 mice reduces the infection-mediated oxidative stress and restrains dengue virus-induced thymic atrophy

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1. scibot 16 Jan 2026
  
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  DOI: 10.1186/s12964-025-02572-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12797958/
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1-s2.0-S2589004225028330-main-html.html

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Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity

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  DOI: 10.1016/j.chom.2025.12.003
  
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sciencedirect.com/science/article/pii/S1931312825005220
Dec 2025
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Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8+ T cell exhaustion in chronic myeloid leukemia

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1-s2.0-S258900422502646X-main-html.html

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54.241.53.176/93de8e6290387b0a29b7a2c9729bf4f9de57ced1/1-s2.0-S258900422502646X-main-html.html
Oct 2025
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Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes

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Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production

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sciencedirect.com/science/article/pii/S2666379125004434
Sep 2025
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E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis

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1. scibot 24 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116332
  
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1-s2.0-S2589004225017985-main-html.html

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52.53.155.43/bfa103a56e03ca8260532bade686a824030c14b2/1-s2.0-S2589004225017985-main-html.html
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Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3267
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12398951/
Aug 2025
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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.08.001
  
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sciencedirect.com/science/article/pii/S1074761325003358
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
Jul 2025
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TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.015
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00265-X
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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.001
  
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May 2025
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Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.ebiom.2025.105734
  
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sciencedirect.com/science/article/pii/S2352396425001781
Apr 2025
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Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity

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1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.02.029
  
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CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

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1. scibot 08 Apr 2025
  
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  DOI: 10.7554/eLife.103417
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11970909/
Mar 2025
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Translation dysregulation in cancer as a source for targetable antigens

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  DOI: 10.1016/j.ccell.2025.03.003
  
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Jan 2025
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High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo

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  DOI: 10.1016/j.celrep.2024.115132
  
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Dec 2024
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Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111248
  
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Sep 2024
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Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell

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Aug 2024
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High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases

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Jul 2024
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SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration

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  DOI: 10.1016/j.celrep.2024.114458
  
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Jun 2024
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Low abundant intestinal commensals modulate immune control of chronic myeloid leukemia stem cells

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  DOI: 10.1101/2024.05.31.595679
  
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biorxiv.org/content/10.1101/2024.05.31.595679v1
May 2024
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Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.003
  
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Inhibiting retinoic acid signaling in dendritic cells suppresses respiratory syncytial virus infection through enhanced antiviral immunity.

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  DOI: 10.1016/j.isci.2024.110103
  
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52.53.155.43/2a3ead8e059542bfa280a0573112e419322b6697/PIIS2589004224013282-html.html
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N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation

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sciencedirect.com/science/article/pii/S1074761324002097
Apr 2024
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.04.003
  
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Jan 2024
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Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization

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1. scibot 09 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113665
  
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Nov 2023
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Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113301
  
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sciencedirect.com/science/article/pii/S221112472301313X
Oct 2023
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High-resolution mapping of cell-cycle dynamics during steady-state T-cell development and regeneration in vivo

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1. scibot 13 Oct 2023
  
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  DOI: 10.1101/2023.06.14.544919
  
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52.53.155.43/5adb9a7f13046637b8804b132dfb3fb0676830a9/2023.06.14.544919v1.full-html.html
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glucose Oxidation-Dependent Survival of Activated B Cells Provides a Putative Novel Therapeutic Target for Lupus Treatment

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107487
  
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Characterizing CD4 T cell differentiation in mouse small intestine using T cell transfer, lamina propria preparation, and flow cytometry

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  DOI: 10.1016/j.xpro.2023.102485
  
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Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

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Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

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Apr 2023
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Active maintenance of CD8+ T cell naïvety through regulation of global genome architecture

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cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory

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Mar 2023
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Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma

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ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery

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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

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The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection

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Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells

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Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection

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p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness

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CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation

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Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection

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Oct 2022
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ccr-22-1357-html.html

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Sep 2022
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Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis

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Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

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Intracellular infection and immune system cues rewire adipocytes to acquire immune function

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Inhibition of CDK4/6 promotes CD8 T cell memory formation

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Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

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Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

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Nov 2021
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Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor

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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

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Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths

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JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

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Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice

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May 2021
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Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection

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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

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The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

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Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice

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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

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Feb 2021
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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

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Jan 2021
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Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

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Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity

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EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance

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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

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Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8+ T Cell Apoptosis to Limit T Cell Immunity

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Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth

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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

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IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression

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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

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Liver Is a Generative Site for the B Cell Response to Ehrlichia muris

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Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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Untitled document

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Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

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Untitled document

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Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development

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KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

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Nov 2017
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L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

3
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