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Fusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.xcrm.2026.103091
  
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sciencedirect.com/science/article/pii/S2666379126005082
Oct 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.cmet.2026.08.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13623212/
Sep 2026
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Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.molcel.2026.08.007
  
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sciencedirect.com/science/article/pii/S109727652600554X
Aug 2026
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Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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1. scibot 31 Aug 2026
  
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  DOI: 10.1016/j.cmet.2026.08.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13623212/
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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

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1. scibot 20 Aug 2026
  
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  DOI: 10.1038/s41418-026-01846-y
  
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nature.com/articles/s41418-026-01846-y
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Cblb Gene Editing in T Cells Sustains Expansion and Immunogenic CAR T Tumor Killing Under Chronic Antigenic Stimulation

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1. scibot 14 Aug 2026
  
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  DOI: 10.3390/cells15151407
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13464884/
Jul 2026
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Septin7 is essential in early hematopoiesis, but redundant at later stages

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1. scibot 17 Jul 2026
  
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  DOI: 10.26508/lsa.202603637
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13365248/
Jun 2026
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A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102884
  
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Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44321-026-00424-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13269783/
Apr 2026
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Single-cell omics and flow cytometry identify distinct immune states of dural and brain-infiltrating IL-17-producing γδ T cells after experimental stroke

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1. scibot 21 Apr 2026
  
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  DOI: 10.1186/s12974-026-03794-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13088706/
Mar 2026
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Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.007
  
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sciencedirect.com/science/article/pii/S0092867426001728
Feb 2026
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Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.immuni.2026.01.006
  
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sciencedirect.com/science/article/pii/S1074761326000270
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Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.001
  
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sciencedirect.com/science/article/pii/S2451945626000334
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An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals

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1. scibot 03 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2025.102582
  
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sciencedirect.com/science/article/pii/S266637912500655X
Sep 2025
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Comparison of immunogenicity and protection efficacy of self-amplifying and circular mRNA vaccines against SARS-CoV-2

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.isci.2025.113498
  
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sciencedirect.com/science/article/pii/S2589004225017596
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The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

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1. scibot 22 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.115799
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12443480/
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Tumors hijack macrophages for iron supply to promote bone metastasis and anemia

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1. scibot 04 Sep 2025
  
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  DOI: 10.1016/j.cell.2025.08.013
  
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sciencedirect.com/science/article/pii/S0092867425009274
Jul 2025
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P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113055
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12303049/
May 2025
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Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115734
  
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sciencedirect.com/science/article/pii/S2211124725005054
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PIM kinase control of CD8 T cell protein synthesis and cell trafficking

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.98622
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074636/
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1-s2.0-S2589004225007692-main-html.html

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1. scibot 18 May 2025
  
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52.53.155.43/bf6cba30678d0d150a13cbeb68660b4f11367a41/1-s2.0-S2589004225007692-main-html.html
Apr 2025
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Pre-existing intratumoral stem-like CD8+ T cells drive radiotherapy-induced tumor immunity

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  DOI: 10.1016/j.celrep.2025.115566
  
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sciencedirect.com/science/article/pii/S2211124725003377
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Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control

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1. scibot 11 Apr 2025
  
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  DOI: 10.1101/2024.10.16.618635
  
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52.53.155.43/ecad09cc9eabd42f0fef0391e2d71b5d66664c67/2024.10.16.618635.full-html.html
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115510
  
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sciencedirect.com/science/article/pii/S2211124725002815
Mar 2025
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Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.chom.2025.03.004
  
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sciencedirect.com/science/article/pii/S1931312825000873
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Translation dysregulation in cancer as a source for targetable antigens

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.03.003
  
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sciencedirect.com/science/article/pii/S1535610825000820
Feb 2025
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis

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1. scibot 26 Feb 2025
  
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  DOI: 10.3389/fendo.2025.1514264
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11847698/
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NFAT single-deficient murine T cells reduce the risk of aGvHD while controlling cytomegalovirus infection

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.111937
  
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sciencedirect.com/science/article/pii/S258900422500197X
Jan 2025
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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

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1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.12.007
  
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sciencedirect.com/science/article/pii/S1550413124004893
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/scisignal.adi8753
  
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science.org/doi/10.1126/scisignal.adi8753
Aug 2024
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.016
  
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sciencedirect.com/science/article/pii/S0092867424007761
Apr 2024
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Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling

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1. scibot 02 Apr 2024
  
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  DOI: 10.1126/scisignal.adh0439
  
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science.org/doi/10.1126/scisignal.adh0439
Jan 2024
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A time- and single-cell-resolved model of murine bone marrow hematopoiesis

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1. scibot 09 Jan 2024
  
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  DOI: 10.1016/j.stem.2023.12.001
  
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sciencedirect.com/science/article/pii/S1934590923004319
Oct 2023
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Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1

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1. scibot 17 Oct 2023
  
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  DOI: 10.1126/sciimmunol.abh0707
  
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science.org/doi/10.1126/sciimmunol.abh0707
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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.ccell.2023.09.011
  
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Detection of the CD8+ T cell immune response in mice infected with OVA-Listeriamonocytogenes

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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

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Interferon-g-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit acute contact dermatitis

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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

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Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin

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Identification of an adipose tissue-resident pro-preadipocyte population

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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

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Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

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Increased Expression of Multiple Co-Inhibitory Molecules on Malaria-Induced CD8+ T Cells Are Associated With Increased Function Instead of Exhaustion

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Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses

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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

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Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse

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Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1

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Activating Mucosal-Associated Invariant T cells Induces a Broad Antitumor Response

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Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

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Nov 2021
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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

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Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation

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The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo

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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

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ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

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Untitled document

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Jul 2021
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The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

1
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  Anti-CD44 (clone IM7)
  
  DOI: 10.1016/j.immuni.2019.10.006
  
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Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

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  DOI: 10.1016/j.immuni.2018.12.011
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.10.057
  
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Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription

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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

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Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

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cell.com/cell-reports/fulltext/S2211-1247(21)00061-9
Nov 2020
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Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

1
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  PE/Cyanine7 anti-mouse/human CD44 Antibody (clone IM7)
  
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer

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High Dimensional Single-Cell Analysis Reveals iNKT Cell Developmental Trajectories and Effector Fate Decision

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Chemokine-Adjuvanted Plasmid DNA Induces Homing of Antigen-Specific and Non–Antigen-Specific B and T Cells to the Intestinal and Genital Mucosae

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Jan 2020
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Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity

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PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation

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Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

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Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

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Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response

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Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

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