164 Matching Annotations
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    Protocol to study synapse density or volume—SynDOVE—in brain using confocal microscopy and Imaris three-dimensional surface rendering software
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    sciencedirect.com/science/article/pii/S2666166726001188
  3. Mar 2026
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    Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain
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    sciencedirect.com/science/article/pii/S0092867426001637
  5. Feb 2026
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    Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12927100/
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    Mapping cellular vulnerability in Parkinson’s disease using retro-AAVs and preformed α-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859986/
  8. Jan 2026
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    A monoclonal antibody targeting the C-terminal of α-synuclein fibrils mitigates pathology in a Parkinson’s disease model
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    sciencedirect.com/science/article/pii/S2211124725016699
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    Skin-derived α-synuclein strains from PD, DLB, and MSA induce distinct intracellular pathology and neurodegeneration
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    sciencedirect.com/science/article/pii/S0021925825028571
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    Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay
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  12. Nov 2025
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    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    Fc-Modified IVIG with Enhanced Blood–Brain Barrier Penetration Ameliorates Cognitive Deficits and Neuropathology in A53T α-Synuclein Transgenic Mice
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    In situ amplification of α-synuclein amyloid fibril reveals a distinct polymorph related to Parkinson’s disease and dementia with Lewy body
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    Parkinson’s disease modeling in regenerative spiny mice (Acomys dimidiatus) captures key disease-relevant behavioral, histological, and molecular signatures
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    biorxiv.org/content/10.1101/2025.11.06.687049v1
  18. Oct 2025
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    TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson’s disease models
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    sciencedirect.com/science/article/pii/S019701862500141X
  20. Sep 2025
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    A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy
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    sciencedirect.com/science/article/pii/S0896627325006245
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    α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
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  23. Aug 2025
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    Structural insights into the activation of TMEM175 by small molecule
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    CD11b Activation Reduces Myeloid Brain Infiltration and Mitigates Synucleinopathy in a Model of Parkinson’s Disease
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    biorxiv.org/content/10.1101/2025.08.11.669712v1
  26. Jul 2025
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    Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12258067/
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    SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
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    eneuro.org/content/8/4/ENEURO.0166-21.2021
  29. Jun 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221657/
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    Low-grade chronic inflammatory stimulation alleviates α‑syn accumulation in Parkinson's disease by activating autophagy to promote neuronal survival in the Thy1-h[A30P]α-syn mouse model
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  33. May 2025
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    Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
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    Microglia-driven inflammation induces progressive tauopathies and synucleinopathies
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    SLC7A11 is an unconventional H+ transporter in lysosomes
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  37. Apr 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits
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    Early A-synuclein aggregation decreases corticostriatal glutamate drive and synapse density
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    Fibril fuzzy coat is important for α-synuclein pathological transmission activity
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  42. Mar 2025
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    Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease
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    Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
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  45. Feb 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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    Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment
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    Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability
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    biorxiv.org/content/10.1101/2024.10.22.619411v1
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    Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease
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    academic.oup.com/hmg/article-abstract/33/20/1771/7727363
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    Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies
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    Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies
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    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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  54. Jan 2025
  55. academic.oup.com academic.oup.com
    Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease
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    Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies
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    Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson’s disease and Dementia with Lewy bodies
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  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11749544/
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    Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation
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    link.springer.com/article/10.1038/s41531-024-00867-z
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    14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity
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    G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
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  62. Dec 2024
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for generation of PD-modeling-induced neurons and detection of α-synuclein forms
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  64. Nov 2024
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
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  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein
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  67. Oct 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
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  69. Sep 2024
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    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
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    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
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  72. Aug 2024
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    Neuromodulation modifies α-synuclein spreading dynamics in vivo and the pattern is predicted by changes in whole-brain function
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  74. Jul 2024
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
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    Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
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  77. Jun 2024
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    1. scibot 06 Jun 2024
      Figure S3Figure S3. List of the antibodies used in this study (related to Figures 1 to 9)A. Antibodies used for the detection of total aSyn.B. Antibodies used for the detection of α-syn phosphorylated at residue S129.C. Other antibodies used in the study.

      DOI: 10.1101/2022.03.30.486322

      Resource: (Abcam Cat# ab51253, RRID:AB_869973)

      Curator: @bandrow

      SciCrunch record: RRID:AB_869973

      What is this?
      RRID:AB_869973

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    Alpha-synuclein aggregates are phosphatase resistant
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    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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  81. May 2024
  82. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
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    Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
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    Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
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    biorxiv.org/content/10.1101/2024.05.09.593334v1
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    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
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    Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson’s Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
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    Alpha-synuclein aggregates are phosphatase resistant
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  88. Apr 2024
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
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    Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
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    Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
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    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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  93. Feb 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
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  95. Dec 2023
  96. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
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    Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration
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    onlinelibrary.wiley.com/doi/10.1111/ejn.16196
  99. Oct 2023
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    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15967
  102. www.cell.com www.cell.com
    Impaired pre-synaptic plasticity and visual responses in Auxilin knockout mice
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    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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  104. Aug 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
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    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
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  108. Jul 2023
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    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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  110. Jun 2023
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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  112. Mar 2023
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  114. Jan 2023
  115. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  116. Nov 2022
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    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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  118. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy
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    onlinelibrary.wiley.com/doi/10.1111/bpa.13131
  119. www.sciencedirect.com www.sciencedirect.com
    Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics
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  121. Sep 2022
  122. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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  123. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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  126. May 2022
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    Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
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  128. Mar 2022
  129. link.springer.com link.springer.com
    Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
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  130. Feb 2022
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    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
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  132. Dec 2021
  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease
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  134. Sep 2021
  135. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy
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    onlinelibrary.wiley.com/doi/10.1111/jcmm.16910
  136. Aug 2021
  137. www.physiology.org www.physiology.org
    Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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  139. Jul 2021
  140. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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    Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
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  142. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
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    Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
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  144. Jun 2021
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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  146. May 2021
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    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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  149. Apr 2021
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    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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  151. Mar 2021
  152. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15257
  153. Feb 2021
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain-Gut Interactions: Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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  155. Nov 2020
  156. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
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  157. Oct 2020
  158. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15199
  159. Sep 2020
  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15107
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
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  162. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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  163. Jan 2020
  164. link.springer.com link.springer.com
    Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
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  165. www.frontiersin.org www.frontiersin.org
    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
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    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  169. Nov 2017
  170. onlinelibrary.wiley.com onlinelibrary.wiley.com
    “Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14139/full
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    Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
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    link.springer.com/article/10.1007/s12035-017-0624-1