74 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein
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    1. scibot 10 Nov 2024
      RRID:AB_869973

      DOI: 10.1038/s41531-024-00824-w

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    pmc.ncbi.nlm.nih.gov/articles/PMC11538257/
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
    1
    1. scibot 02 Oct 2024
      RRID:AB_869973

      DOI: 10.1186/s12974-024-03221-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC11438102/
  5. Sep 2024
  6. www.biorxiv.org www.biorxiv.org
    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
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    1. scibot 28 Sep 2024
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      DOI: 10.1101/2024.09.20.613717

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    biorxiv.org/content/10.1101/2024.09.20.613717v1
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
    1
    1. scibot 26 Sep 2024
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      DOI: 10.1101/2024.08.30.610586

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    ncbi.nlm.nih.gov/pmc/articles/PMC11384018/
  8. Aug 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Neuromodulation modifies α-synuclein spreading dynamics in vivo and the pattern is predicted by changes in whole-brain function
    1
    1. scibot 19 Aug 2024
      RRID:AB_869973

      DOI: 10.1016/j.brs.2024.07.021

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    sciencedirect.com/science/article/pii/S1935861X24001360
  10. Jul 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
    1
    1. scibot 30 Jul 2024
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      DOI: 10.1016/j.neuron.2024.06.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  12. www.sciencedirect.com www.sciencedirect.com
    Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.nbd.2024.106595

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    sciencedirect.com/science/article/pii/S0969996124001955
  13. Jun 2024
  14. Local file Local file
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    1. scibot 06 Jun 2024
      Figure S3Figure S3. List of the antibodies used in this study (related to Figures 1 to 9)A. Antibodies used for the detection of total aSyn.B. Antibodies used for the detection of α-syn phosphorylated at residue S129.C. Other antibodies used in the study.

      DOI: 10.1101/2022.03.30.486322

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  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
    1
    1. scibot 04 Jun 2024
      RRID:AB_869973

      DOI: 10.1186/s40478-024-01785-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
    1
    1. scibot 03 Jun 2024
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      DOI: 10.1038/s41467-024-49016-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
  17. May 2024
  18. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
    1
    1. scibot 30 May 2024
      RRID:AB_869973

      DOI: 10.1101/2024.05.24.595642

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      RRID:AB_869973 DOI:10.1101/2024.05.24.595642
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    biorxiv.org/content/10.1101/2024.05.24.595642v1
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
    2
    1. scibot 24 May 2024
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      DOI: 10.1038/s41531-024-00679-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11109094/
  20. www.biorxiv.org www.biorxiv.org
    Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
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    1. scibot 16 May 2024
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      DOI: 10.1101/2024.05.09.593334

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    biorxiv.org/content/10.1101/2024.05.09.593334v1
  21. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    1
    1. scibot 10 May 2024
      ab51253; Abcam

      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  22. www.biorxiv.org www.biorxiv.org
    Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson’s Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
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      DOI: 10.1101/2024.04.22.590542

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    biorxiv.org/content/10.1101/2024.04.22.590542v1
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
    1
    1. scibot 01 May 2024
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      DOI: 10.1101/2023.11.20.567854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030248/
  24. Apr 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
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    1. scibot 30 Apr 2024
      RRID:AB_869973

      DOI: 10.1038/s41598-024-60613-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11055870/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1007/s10571-024-01472-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11052719/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
    1
    1. scibot 19 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10904737/
  28. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    1. scibot 05 Apr 2024
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      DOI: 10.1038/s41419-024-06534-8

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    nature.com/articles/s41419-024-06534-8
  29. Feb 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
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    1. scibot 06 Feb 2024
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      DOI: 10.1093/brain/awad388

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834249/
  31. Dec 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.neuron.2023.11.020

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    sciencedirect.com/science/article/pii/S0896627323008942
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    1. scibot 22 Dec 2023
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      DOI: 10.1038/s41467-023-44033-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Combining fibril-induced alpha-synuclein aggregation and 6-hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration
    2
    1. scibot 16 Dec 2023
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      AB_869973

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    onlinelibrary.wiley.com/doi/10.1111/ejn.16196
  35. Oct 2023
  36. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    1. scibot 17 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113244

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    sciencedirect.com/science/article/pii/S2211124723012561
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms
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    1. scibot 13 Oct 2023
      RRID:AB_869973

      DOI: 10.1111/jnc.15967

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15967
  38. www.cell.com www.cell.com
    Impaired pre-synaptic plasticity and visual responses in Auxilin knockout mice
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    1. scibot 06 Oct 2023
      AB_869973

      DOI: 10.1016/j.isci.2023.107842

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    cell.com/iscience/abstract/S2589-0042(23)01919-3
  39. www.cell.com www.cell.com
    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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    1. scibot 06 Oct 2023
      RRID:AB_869973

      DOI: 10.1016/j.celrep.2023.113071

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    cell.com/cell-reports/abstract/S2211-1247(23)01082-3
  40. Aug 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
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    1. scibot 31 Aug 2023
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      DOI: 10.1038/s41531-023-00570-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10462645/
  42. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.brainres.2021.147383

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    sciencedirect.com/science/article/pii/S0006899321001086
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease neurons exhibit alterations in mitochondrial quality control proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10409763/
  44. Jul 2023
  45. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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    1. scibot 19 Jul 2023
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      DOI: 10.1101/2023.06.05.543428

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    52.53.155.43/5185b06857919afc7fae38712332798a8a903a3a/2023.06.05.543428v1.full-html.html
  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  48. Mar 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
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      RRID:AB_869973

      DOI: 10.1016/j.celrep.2023.112231

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    sciencedirect.com/science/article/pii/S2211124723002425
  50. Jan 2023
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions
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    1. scibot 19 Jan 2023
      RRID:AB_869973

      DOI: 10.1523/JNEUROSCI.0680-22.2022

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    pmc.ncbi.nlm.nih.gov/articles/PMC9864632/
  52. Nov 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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      DOI: 10.1016/j.crmeth.2022.100338

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    sciencedirect.com/science/article/pii/S2667237522002351
  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy
    1
    1. scibot 15 Nov 2022
      RRID:AB_869973

      DOI: 10.1111/bpa.13131

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    onlinelibrary.wiley.com/doi/10.1111/bpa.13131
  55. www.sciencedirect.com www.sciencedirect.com
    Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics
    1
    1. scibot 09 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111631

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  56. journals.lww.com journals.lww.com
    Neuroprotective effects of insulin-like growth factor-2 in... : Neural Regeneration Research
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  57. Sep 2022
  58. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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  59. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  62. May 2022
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    Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
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  64. Mar 2022
  65. link.springer.com link.springer.com
    Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
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  66. Feb 2022
  67. www.sciencedirect.com www.sciencedirect.com
    Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
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  68. Dec 2021
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease
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  70. Sep 2021
  71. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy
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  72. Aug 2021
  73. www.physiology.org www.physiology.org
    Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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  75. Jul 2021
  76. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sensitivity and specificity of phospho‐Ser129 α‐synuclein monoclonal antibodies
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  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
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  79. www.sciencedirect.com www.sciencedirect.com
    Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease
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  80. Jun 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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  82. May 2021
  83. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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  85. Apr 2021
  86. www.sciencedirect.com www.sciencedirect.com
    Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice
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  87. Mar 2021
  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease
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  89. Feb 2021
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brain-Gut Interactions: Altered gastric tone and motility response to brain-stem dopamine in a rat model of parkinsonism
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  91. Nov 2020
  92. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells
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  93. Oct 2020
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
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  95. Sep 2020
  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
    H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications
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  98. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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  99. Jan 2020
  100. link.springer.com link.springer.com
    Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
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  101. www.frontiersin.org www.frontiersin.org
    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
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  102. www.sciencedirect.com www.sciencedirect.com
    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
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      DOI: 10.1016/j.neuron.2019.12.004

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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  105. Nov 2017
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    “Prion‐like” propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum
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    Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC
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