43 Matching Annotations
  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  3. Feb 2024
  4. www.sciencedirect.com www.sciencedirect.com
    DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling
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    sciencedirect.com/science/article/pii/S221112472400041X
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    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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    cell.com/cell/fulltext/S0092-8674(24)00006-0
  6. Jan 2024
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
    1
    1. scibot 06 Jan 2024
      RRID:AB_915788

      DOI: 10.1016/j.jbc.2023.105619

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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  8. Dec 2023
  9. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015474
  10. Aug 2023
  11. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    2. scibot 10 Aug 2023
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  12. Jun 2023
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    Identification of XAF1 as an endogenous AKT inhibitor
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    1. scibot 29 Jun 2023
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    sciencedirect.com/science/article/pii/S2211124723007015
  14. May 2023
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    Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease
    1
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    sciencedirect.com/science/article/pii/S1931312823001671
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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    sciencedirect.com/science/article/pii/S2211124723005004
  17. Apr 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    1. scibot 21 Apr 2023
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    Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
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    nature.com/articles/s41398-023-02411-8
  20. Nov 2022
  21. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
    1
    1. scibot 03 Nov 2022
      AB_915788

      DOI: 10.1210/endocr/bqac170

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    academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
  22. Aug 2022
  23. www.sciencedirect.com www.sciencedirect.com
    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
    1
    1. scibot 12 Aug 2022
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      DOI: 10.1016/j.isci.2022.104827

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    sciencedirect.com/science/article/pii/S2589004222010999
  24. Jul 2022
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
    1
    1. scibot 31 Jul 2022
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      DOI: 10.3390/ijms23147774

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    ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation
    1
    1. scibot 27 Jul 2022
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      DOI: 10.1111/febs.16375

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    ncbi.nlm.nih.gov/pmc/articles/PMC9309721/
  27. May 2022
  28. www.nature.com www.nature.com
    Convergent somatic mutations in metabolism genes in chronic liver disease
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      DOI: 10.1038/s41586-021-03974-6

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    nature.com/articles/s41586-021-03974-6
  29. Dec 2021
  30. www.sciencedirect.com www.sciencedirect.com
    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
    1
    1. scibot 11 Dec 2021
      2938S

      DOI: 10.1016/j.jcmgh.2021.11.007

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    sciencedirect.com/science/article/pii/S2352345X21002411
  31. Oct 2021
  32. academic.oup.com academic.oup.com
    A role for AKT1 in nonsense-mediated mRNA decay
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    1. scibot 15 Oct 2021
      2938

      DOI: 10.1093/nar/gkab882

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab882/6389627
  33. Jul 2021
  34. jcs.biologists.org jcs.biologists.org
    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
    1
    1. scibot 31 Jul 2021
      Akt 1

      DOI: 10.1242/jcs.233221

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    jcs.biologists.org/content/132/20/jcs233221
  35. www.sciencedirect.com www.sciencedirect.com
    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
    1
    1. scibot 27 Jul 2021
      RRID:AB_10829158

      DOI: 10.1016/j.stem.2019.09.009

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    sciencedirect.com/science/article/pii/S1934590919304205
  36. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 27 Jul 2021
      RRID:AB_10829158

      DOI: 10.1016/j.neuron.2018.10.051

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    sciencedirect.com/science/article/pii/S0896627318309590
  37. www.sciencedirect.com www.sciencedirect.com
    Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability
    1
    1. scibot 09 Jul 2021
      RRID:AB_10829158

      DOI: 10.1016/j.celrep.2021.109327

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    sciencedirect.com/science/article/pii/S2211124721007038
  38. May 2021
  39. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    1. scibot 19 May 2021
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      DOI: 10.1016/j.celrep.2021.109128

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    sciencedirect.com/science/article/pii/S2211124721004678
  40. www.sciencedirect.com www.sciencedirect.com
    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuron.2021.03.008

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    sciencedirect.com/science/article/pii/S0896627321001562
  41. Apr 2021
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
    1
    1. scibot 06 Apr 2021
      RRID:AB_915788

      DOI: 10.7554/eLife.61313

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    ncbi.nlm.nih.gov/pmc/articles/PMC7997661/
  43. Feb 2021
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
    1
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      RRID:AB_915788

      DOI: 10.1016/j.ccell.2017.05.006

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    ncbi.nlm.nih.gov/pmc/articles/PMC7909318/
  45. link.springer.com link.springer.com
    Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells
    1
    1. scibot 27 Feb 2021
      RRID:AB_915788

      DOI: 10.1007/s10637-020-01050-w

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    link.springer.com/article/10.1007/s10637-020-01050-w
  46. Jan 2021
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
    1
    1. scibot 13 Jan 2021
      RRID:AB_915788

      DOI: 10.7554/eLife.56630

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    ncbi.nlm.nih.gov/pmc/articles/PMC7787664/
  48. Oct 2020
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
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      RRID:AB_915788

      DOI: 10.7554/eLife.58941

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    ncbi.nlm.nih.gov/pmc/articles/PMC7541086/
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
    1
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      DOI: 10.1016/j.celrep.2020.108223

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    sciencedirect.com/science/article/pii/S2211124720312122
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BPS Publications
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      RRID:AB_915788

      DOI: 10.1111/bph.15236

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    ncbi.nlm.nih.gov/pmc/articles/PMC7520443/
  52. Jan 2020
  53. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    1. scibot 13 Jan 2020
      RRID:AB_915788

      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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      DOI: 10.1016/j.molcel.2019.07.023

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    sciencedirect.com/science/article/pii/S1097276519305532
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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      DOI: 10.1016/j.immuni.2019.11.015

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    sciencedirect.com/science/article/pii/S1074761319304960
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    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
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      RRID:AB_915788

      DOI: 10.1016/j.celrep.2019.02.096

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    sciencedirect.com/science/article/pii/S2211124719302827
  57. Nov 2018
  58. www.sciencedirect.com www.sciencedirect.com
    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    sciencedirect.com/science/article/pii/S0028390818302429
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    sciencedirect.com/science/article/pii/S1097276518301084
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    Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53
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    sciencedirect.com/science/article/pii/S1097276518300522
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  62. Nov 2017
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    1. scibot 08 Nov 2017
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    sciencedirect.com/science/article/pii/S1535610817302027