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  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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    1. scibot 16 Nov 2024
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    sciencedirect.com/science/article/pii/S1534580724006270
  3. Nov 2024
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    VPS4A is the selective receptor for lipophagy in mice and humans
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    sciencedirect.com/science/article/pii/S1097276524008621
  5. Oct 2024
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    Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11433901/
  7. Sep 2024
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    cell.com/cell/fulltext/S0092-8674(24)00911-5
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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    sciencedirect.com/science/article/pii/S2211124724010799
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    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease
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  12. Aug 2024
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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  14. Jul 2024
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
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    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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  18. Jun 2024
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    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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    sciencedirect.com/science/article/pii/S0092867424005269
  20. May 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization
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    TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis
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  24. Mar 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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  26. Feb 2024
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    UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis
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    sciencedirect.com/science/article/pii/S2211124724001360
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
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    The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
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      DOI: 10.1007/s00018-024-05115-4

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    link.springer.com/article/10.1007/s00018-024-05115-4
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    The HRI branch of the integrated stress response selectively triggers mitophagy
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    sciencedirect.com/science/article/pii/S1097276524000522
  32. Jan 2024
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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    sciencedirect.com/science/article/pii/S1535610823004476
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
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      DOI: 10.1016/j.stem.2023.12.003

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    sciencedirect.com/science/article/pii/S1934590923004332
  36. Dec 2023
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    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
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    sciencedirect.com/science/article/pii/S0969996123003868
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    Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
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    sciencedirect.com/science/article/pii/S2211124723015413
  39. Nov 2023
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    sciencedirect.com/science/article/pii/S1550413123003868
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    Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
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    sciencedirect.com/science/article/pii/S2211124723014481
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    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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  44. Oct 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells
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      DOI: 10.3390/biology12091225

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    ncbi.nlm.nih.gov/pmc/articles/PMC10525791/
  46. Sep 2023
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects
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      DOI: 10.1111/acel.13954

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    onlinelibrary.wiley.com/doi/10.1111/acel.13954
  48. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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      DOI: 10.15252/embr.202356948

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    embopress.org/doi/full/10.15252/embr.202356948
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    sciencedirect.com/science/article/pii/S1534580723004094
  50. Aug 2023
  51. 52.53.155.43 52.53.155.43
    PIIS2589004223017029-html.html
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    Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
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  53. Jul 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
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    sciencedirect.com/science/article/pii/S2211124723007192
  55. Jun 2023
  56. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
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    Apolipoprotein E intersects with amyloid-β within neurons
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  58. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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  62. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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  71. Mar 2023
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    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
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    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
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  74. Feb 2023
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    EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins
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  78. Dec 2022
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    The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations
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  80. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites
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  84. Sep 2022
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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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    Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis
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    Autophagy modulates cell fate decisions during lineage commitment
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  88. Aug 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  92. Jun 2022
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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  95. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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  100. Mar 2022
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    DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions
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  102. Jan 2022
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    ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice
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  104. Dec 2021
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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  106. Nov 2021
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  108. Oct 2021
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    Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase
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    The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
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    Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
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  130. Jul 2021
  131. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1‐dependent autophagy
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    Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
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      Rabbit polyclonal Anti-LC3B

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    Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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    Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin
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    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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  170. Feb 2021
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    Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle
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    Metabolism, Oxidative Stress and Cell Signaling: Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice
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  174. Jan 2021
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    ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
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    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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    Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
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    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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  179. Dec 2020
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    Mitochondrial dysfunction in skeletal muscle of fukutin deficient mice is resistant to exercise‐ and AICAR‐induced rescue
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    Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
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    Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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    AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival
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    Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model
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    Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
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    Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
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    ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
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    The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1
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    Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy
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    IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration
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    Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity
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    Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
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    Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1
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    Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
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    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
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    The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
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    GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
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    TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
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    Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway
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    Tumor necrosis factor receptor‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses
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    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
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    Autophagy inhibition in endogenous and nutrient‐deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro
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