60 Matching Annotations
  1. Jun 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181884/
  3. Apr 2025
  4. www.jneurosci.org www.jneurosci.org
    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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    jneurosci.org/content/45/10/e0967242025
  5. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225006911-main-html.html
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    52.53.155.43/9030c799c07d6c73fd2245d204001a1cff44120f/1-s2.0-S2589004225006911-main-html.html
  6. Feb 2025
  7. 52.53.155.43 52.53.155.43
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    52.53.155.43/ccdd8f2b9b0076ccdaf42c273b248e5adbb5da1d/2024.09.09.611621v1.full-html.html
  8. Sep 2024
  9. www.pnas.org www.pnas.org
    MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms
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    pnas.org/doi/10.1073/pnas.2322978121
  10. Aug 2024
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    <em>Neuropathology and Applied Neurobiology</em> | BNS Journal | Wiley Online Library
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    onlinelibrary.wiley.com/doi/10.1111/nan.12991
  12. Jun 2024
  13. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations
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    alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13904
  14. May 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
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    sciencedirect.com/science/article/pii/S0896627324003295
  16. Feb 2024
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptic adhesion molecule protocadherin-γC5 mediates β-amyloid-induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16066
  18. Aug 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of the Novel Myelin Protein CMTM5 in Multiple Sclerosis Lesions and Its Involvement in Oligodendroglial Stress Responses
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    ncbi.nlm.nih.gov/pmc/articles/PMC10453064/
  20. Jul 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment
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    sciencedirect.com/science/article/pii/S2211124723007854
  22. May 2023
  23. link.springer.com link.springer.com
    Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
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    link.springer.com/article/10.1186/s12974-023-02784-z
  24. Mar 2023
  25. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15750
  26. Oct 2022
  27. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    sciencedirect.com/science/article/pii/S0092867422012521
  28. Sep 2022
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endoplasmic reticulum stress induces Alzheimer's disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15687
  30. Aug 2022
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9395645/
  32. Jul 2022
  33. www.sciencedirect.com www.sciencedirect.com
    Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice
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    sciencedirect.com/science/article/pii/S2211124722008609
  34. Jun 2022
  35. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15650
  36. www.sciencedirect.com www.sciencedirect.com
    Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S2211124722006581
  37. Mar 2022
  38. www.nature.com www.nature.com
    White matter integrity in mice requires continuous myelin synthesis at the inner tongue
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    nature.com/articles/s41467-022-28720-y
  39. Oct 2021
  40. www.sciencedirect.com www.sciencedirect.com
    Cold exposure protects from neuroinflammation through immunologic reprogramming
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    sciencedirect.com/science/article/pii/S1550413121004800
  41. Aug 2021
  42. link.springer.com link.springer.com
    Untitled document
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    link.springer.com/article/10.1007/s00418-019-01786-4
  43. www.nature.com www.nature.com
    Untitled document
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    nature.com/articles/s41598-018-31957-7
  44. Jul 2021
  45. www.sciencedirect.com www.sciencedirect.com
    Transient increase in sAPPα secretion in response to Aβ1–42 oligomers: an attempt of neuronal self-defense?
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    sciencedirect.com/science/article/pii/S0197458017303019
  46. link.springer.com link.springer.com
    Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
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    link.springer.com/article/10.1007/s11011-019-00488-z
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC8188302/
  48. Feb 2021
  49. www.nature.com www.nature.com
    MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
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    nature.com/articles/s41380-020-0824-3
  50. portlandpress.com portlandpress.com
    The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43
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    portlandpress.com/bioscirep/article/40/4/BSR20200435/222674/The-cellular-expression-and-proteolytic-processing
  51. Jan 2021
  52. www.sciencedirect.com www.sciencedirect.com
    Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
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    sciencedirect.com/science/article/pii/S2211124720315771
  53. Dec 2020
  54. www.cell.com www.cell.com
    Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury
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    cell.com/neuron/abstract/S0896-6273(20)30757-1
  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cuprizone‐induced demyelination triggers a CD8‐pronounced T cell recruitment
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    onlinelibrary.wiley.com/doi/10.1002/glia.23937
  56. Nov 2020
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Absence of R‐Ras1 and R‐Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model
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    onlinelibrary.wiley.com/doi/10.1002/glia.23917
  58. Sep 2020
  59. www.sciencedirect.com www.sciencedirect.com
    NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation
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    sciencedirect.com/science/article/pii/S2211124720302278
  60. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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    jneurosci.org/content/40/2/459
  61. www.eneuro.org www.eneuro.org
    Traumatic Brain Injury Preserves Firing Rates but Disrupts Laminar Oscillatory Coupling and Neuronal Entrainment in Hippocampal CA1
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    eneuro.org/content/7/5/ENEURO.0495-19.2020
  62. elifesciences.org elifesciences.org
    A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21
    1
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    elifesciences.org/articles/56223
  63. Jan 2020
  64. jcb.rupress.org jcb.rupress.org
    A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
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    jcb.rupress.org/content/218/2/644
  65. www.sciencedirect.com www.sciencedirect.com
    Laquinimod ameliorates secondary brain inflammation
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    sciencedirect.com/science/article/pii/S096999611930350X
  66. www.mdpi.com www.mdpi.com
    Stereological Investigation of Regional Brain Volumes after Acute and Chronic Cuprizone-Induced Demyelination
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    mdpi.com/2073-4409/8/9/1024/htm
  67. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
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    sciencedirect.com/science/article/pii/S0896627319308839
  68. www.sciencedirect.com www.sciencedirect.com
    Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription
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    sciencedirect.com/science/article/pii/S0092867419308438
  69. www.sciencedirect.com www.sciencedirect.com
    Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
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    sciencedirect.com/science/article/pii/S0896627319310463
  70. www.sciencedirect.com www.sciencedirect.com
    Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease
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    sciencedirect.com/science/article/pii/S1074761319305230
  71. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
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    sciencedirect.com/science/article/pii/S1934590918306039
  72. Nov 2018
  73. link.springer.com link.springer.com
    Untitled document
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    link.springer.com/article/10.1007/s12035-018-1353-9
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6133964/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC6142048/
  76. www.sciencedirect.com www.sciencedirect.com
    Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression
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    sciencedirect.com/science/article/pii/S0896627318306834
  77. www.sciencedirect.com www.sciencedirect.com
    Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
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    sciencedirect.com/science/article/pii/S107476131830075X
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Calmodulin‐like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14258/full
  79. Nov 2017
  80. www.nature.com www.nature.com
    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
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    nature.com/articles/s41598-017-11654-7
  81. www.sciencedirect.com www.sciencedirect.com
    TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0092867417308309
  82. elifesciences.org elifesciences.org
    NPTX2 and cognitive dysfunction in Alzheimer’s Disease
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    elifesciences.org/content/6/e23798
  83. www.jneurosci.org www.jneurosci.org
    Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport
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    jneurosci.org/content/36/37/9647.full
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC5130271/
  85. www.sciencedirect.com www.sciencedirect.com
    Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
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    sciencedirect.com/science/article/pii/S0896627316301763
  86. bmcneurosci.biomedcentral.com bmcneurosci.biomedcentral.com
    PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons
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    bmcneurosci.biomedcentral.com/articles/10.1186/s12868-015-0152-8