149 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11348215/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study
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    pmc.ncbi.nlm.nih.gov/articles/PMC9937660/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6863627/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytokinesis Arrest-induced Binucleation of Macrophages Produces Highly Efficient Efferocytes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13640658/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12690534/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-Wide Screening Reveals the Oncolytic Mechanism of Newcastle Disease Virus in a Human Colonic Carcinoma Cell Line
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12390116/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Host Factors for Rift Valley Fever Phlebovirus
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10675714/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8618713/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated Multi-Omics Analyses Identify Core Determinants Governing Newcastle Disease Virus Oncolytic Therapy Efficacy Under Tumor Heterogeneity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13707497/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Disruption of RNA Splicing Increases Vulnerability of Cells to DNA-PK Inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11546466/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7760831/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-Throughput CRISPR Screening in Hematological Neoplasms
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    pmc.ncbi.nlm.nih.gov/articles/PMC9329962/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6360163/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9289101/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11872725/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10104263/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9638865/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8097382/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy‐linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS‐CoV‐2 entry into human cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9627672/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive Investigation of a Tyrosine Kinase Inhibitor-Resistant Gene Zeste White 10 in Hepatocellular Carcinoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11954606/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GO-CRISPR: A highly controlled workflow to discover gene essentiality in loss-of-function screens
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11654918/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8381345/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic functional identification of cancer multi-drug resistance genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC7006212/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel treatment strategy for lapatinib resistance in a subset of HER2-amplified gastric cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8366014/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10589794/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11923432/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular determinants of response to high-dose androgen therapy in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC6795499/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemotherapy-induced distal enhancers drive transcriptional programs to maintain the chemoresistant state in ovarian cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6744966/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spindle assembly checkpoint inhibition can resensitize p53-null stem cells to cancer chemotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC6497569/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen for essential cell growth mediators in mutant KRAS colorectal cancers
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5690866/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide CRISPR screen identifies genes critical for resistance to FLT3 inhibitor AC220
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5559306/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8865549/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies GNE as a key host factor that promotes influenza A virus adsorption and endocytosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10715076/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    COG6 is an essential host factor for influenza A virus infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12502754/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7652404/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs
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    pmc.ncbi.nlm.nih.gov/articles/PMC7845644/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9765692/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6747720/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12345153/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9093107/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11998517/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11578089/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6803288/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of Proteolytic Targeting of LCK as a Therapeutic Approach in T-cell Acute Lymphoblastic Leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9730446/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9750140/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Apolipoprotein E mediates cell resistance to influenza virus infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC9491715/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS‐mutant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC7383499/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nodularin‐R Synergistically Enhances Abiraterone Against Castrate‐ Resistant Prostate Cancer via PPP1CA Inhibition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11569623/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9‐mediated whole genomic wide knockout screening identifies mitochondrial ribosomal proteins involving in oxygen‐glucose deprivation/reperfusion resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7417733/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas
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    pmc.ncbi.nlm.nih.gov/articles/PMC8168556/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601499/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of host factors for Rift Valley Fever Phlebovirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC10557628/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    https://medrxiv.org/cgi/content/10.1101/2021.04.09.21255184
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    pmc.ncbi.nlm.nih.gov/articles/PMC8057256/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC6662966/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde
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    pmc.ncbi.nlm.nih.gov/articles/PMC6484886/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC6484884/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673855/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC7897519/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NEMF-mediated CAT tailing facilitates translocation-associated quality control
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010919/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC6891097/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC4949453/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
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    pmc.ncbi.nlm.nih.gov/articles/PMC9629075/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6937574/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012052/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12415228/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic
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    pmc.ncbi.nlm.nih.gov/articles/PMC11874154/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9169118/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC6196492/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5625932/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC7994904/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mechanism by which FGF23/FGFR-1 activates NOX2-ROS in vascular endothelial cells in the context of severe heat stroke-induced acute lung injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12356372/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12855803/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR knockout screen implicates three genes in lysosome function
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    pmc.ncbi.nlm.nih.gov/articles/PMC6610096/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen
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    pmc.ncbi.nlm.nih.gov/articles/PMC6362041/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823391/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FPR1 is the plague receptor on host immune cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC6776691/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs
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    pmc.ncbi.nlm.nih.gov/articles/PMC7677226/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide screen identifies genes required for erythroid differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11993733/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11788441/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC10920751/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC8993893/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8642546/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7018848/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6491561/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR-Cas9 knockout screening in hepatocellular carcinoma with lenvatinib resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8602346/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8858321/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of oxidative phosphorylation augments antineoplastic activity of mitotic aurora kinase inhibition
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8484571/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR screening for potential targets of ginsenoside compound K
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6971025/
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10628277/
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8458386/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5526071/
  95. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5302127/
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9615120/
  97. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GPR108 Is a Highly Conserved AAV Entry Factor
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7000996/
  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6336797/
  99. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Balancing off-target and on-target considerations for optimized CRISPR-Cas9 knockout library design
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13174248/
  100. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5626917/
  101. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6838448/
  102. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9481707/
  103. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11928284/
  104. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Assessment of gamma-glutamyl carboxylase activity in its native milieu
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12276977/
  105. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8019017/
  106. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7852694/
  107. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome‐Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6618319/
  108. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021087/
  109. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome‐scale CRISPR screening identifies cell cycle and protein ubiquitination processes as druggable targets for erlotinib‐resistant lung cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7858278/
  110. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6156083/
  111. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-Deoxysphingolipids Require Very-Long-Chain Ceramide Synthesis to Induce ER Stress and Neurotoxicity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710655/
  112. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Cellular Factors Required for SARS-CoV-2 Replication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8622730/
  113. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SRRM4 Knockout Helps the Human Mesenchymal Stem Cell Line to Penetrate Decellularized Cancellous Bone
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12729399/
  114. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo CRISPR screening links NFKB1 to endocrine resistance in ER+ breast cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13648772/
  115. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRD9 is a druggable component of interferon‐stimulated gene expression and antiviral activity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8490982/
  116. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8488563/
  117. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6258447/
  118. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8610583/
  119. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A human apolipoprotein L with detergent-like activity kills intracellular pathogens
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8422858/
  120. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8397268/
  121. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7840125/
  122. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC5991512/
  123. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9825716/
  124. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10756275/
  125. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC4828653/
  126. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7511089/
  127. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An improved method for high-throughput quantification of autophagy in mammalian cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7376206/
  128. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7093534/
  129. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6823505/
  130. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6529431/
  131. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6983325/
  132. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11631977/
  133. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8144221/
  134. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing
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    pmc.ncbi.nlm.nih.gov/articles/PMC7904777/
  135. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of ELF2 drives topotecan resistance in retinoblastoma revealed by genome-wide CRISPR-Cas9 screening
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847836/
  136. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9744908/
  137. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC9903835/
  138. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-Deoxysphingolipids require very-long-chain ceramide synthesis to induce ER stress and cytotoxicity
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13382789/
  139. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC10339196/
  140. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
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    pmc.ncbi.nlm.nih.gov/articles/PMC6541931/
  141. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
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    pmc.ncbi.nlm.nih.gov/articles/PMC12362812/
  142. Oct 2026
  143. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identified NEK6 as a determinant of sensitivity to CDK4/6 inhibitor in endometrial cancer
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12813190/
  144. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR and compound screens in a novel ex vivo tissue model identify DDR1 and ETA as regulators of cancer cell invasion
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13277066/
  145. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of HSPE1 as a new actionable cancer vulnerability leads to an innovative and effective combination therapy for pancreatic ductal adenocarcinoma
    2
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    pmc.ncbi.nlm.nih.gov/articles/PMC12973555/
  146. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rab10 coordinates SADS-CoV non-lytic egress through the ERGIC-TGN-lysosome trafficking pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC13561426/
  147. Sep 2026
  148. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13534483/