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SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages

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1. scibot 07 Aug 2026
  
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  Addgene_102597
  
  DOI: 10.1126/sciadv.aea2780
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13440407/
May 2026
www.biorxiv.org www.biorxiv.org

RNA length and receptor usage define innate immune recognition across species

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1. scibot 28 May 2026
  
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  Addgene plasmid no. 102597
  
  DOI: 10.64898/2026.05.21.726451
  
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2. scibot 28 May 2026
  
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  plasmid_102597
  
  DOI: 10.64898/2026.05.21.726451
  
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biorxiv.org/content/10.64898/2026.05.21.726451v1
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NAT10 Suppresses RNA Sensing Induced IFN-β Transactivation to Promote Viral Infection via Interfering with IRF3 Activities

1
1. scibot 23 Nov 2025
  
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  102597
  
  DOI: 10.1101/2025.09.01.673489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12424707/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation

1
1. scibot 23 Nov 2025
  
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  102597
  
  DOI: 10.1038/s41467-025-63554-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12480066/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Live biotherapeutic enterococcus lactis MNC-168 promotes the efficacy of immune checkpoint blockade in cancer therapy by activating STING pathway via bacterial membrane vesicles

1
1. scibot 23 Nov 2025
  
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  Plasmid_102597
  
  DOI: 10.1080/19490976.2025.2557978
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12439585/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1

1
1. scibot 20 Jul 2025
  
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  102597
  
  DOI: 10.34133/research.0764
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12231193/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

1
1. scibot 15 Jun 2025
  
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  Addgene_102597
  
  DOI: 10.7554/eLife.102301
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12119088/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MAPK15 Prevents IFNB1 Expression by Suppressing Oxidative Stress-Dependent Activation of the JNK-JUN Pathway

1
1. scibot 14 Jun 2025
  
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  102597
  
  DOI: 10.3390/ijms26115148
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12155439/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Effective recognition of double-stranded RNA does not require activation of cellular inflammation

1
1. scibot 16 May 2025
  
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  102597
  
  DOI: 10.1126/sciadv.ads6498
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980852/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA

1
1. scibot 05 Apr 2025
  
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  102597
  
  DOI: 10.1038/s44318-025-00370-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962129/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Divergent Effects of Circoviridae Capsid Proteins on Type I Interferon Signaling

1
1. scibot 29 Jan 2025
  
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  RRID:Addgene_102597
  
  DOI: 10.3390/pathogens14010068
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11768430/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Birth of protein folds and functions in the virome

1
1. scibot 25 Sep 2024
  
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  102597
  
  DOI: 10.1038/s41586-024-07809-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11410667/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Conserved Antagonization of Type I Interferon Signaling by Arterivirus GP5 Proteins

1
1. scibot 12 Sep 2024
  
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  RRID:Addgene_102597
  
  DOI: 10.3390/v16081240
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11358952/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

1
1. scibot 26 Aug 2024
  
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  Addgene_102597
  
  DOI: 10.1101/2024.05.09.593370
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11326134/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of the proteolytic signature in CVB3-infected cells

1
1. scibot 18 Aug 2024
  
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  Addgene_102597
  
  DOI: 10.1128/jvi.00498-24
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11265341/
Jun 2024
www.biorxiv.org www.biorxiv.org

Effective recognition of double-stranded RNA does not require activation of cellular inflammation

1
1. scibot 06 Jun 2024
  
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  plasmid_102597
  
  DOI: 10.1101/2024.05.24.595663
  
  Resource: RRID:Addgene_102597
  
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biorxiv.org/content/10.1101/2024.05.24.595663v1
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling

1
1. scibot 18 Apr 2024
  
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  RRID:Addgene_102597
  
  DOI: 10.3390/ijms25073753
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11011558/
www.sciencedirect.com www.sciencedirect.com

DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage

2
1. scibot 12 Apr 2024
  
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  Addgene_102597
  
  DOI: 10.1016/j.cels.2024.03.003
  
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2. scibot 12 Apr 2024
  
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  Addgene_102597
  
  DOI: 10.1016/j.cels.2024.03.003
  
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sciencedirect.com/science/article/pii/S2405471224000887
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

African swine fever virus early protein pI73R suppresses the type-I IFN promoter activities

1
1. scibot 17 Mar 2024
  
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  102597
  
  DOI: 10.1016/j.virusres.2024.199342
  
  Resource: RRID:Addgene_102597
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10918272/
Aug 2023
www.sciencedirect.com www.sciencedirect.com

4-Octyl itaconate restricts STING activation by blocking its palmitoylation

1
1. scibot 25 Aug 2023
  
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  Addgene_102597
  
  DOI: 10.1016/j.celrep.2023.113040
  
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sciencedirect.com/science/article/pii/S2211124723010513
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses

1
1. scibot 24 Jun 2023
  
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  RRID:Addgene_102597
  
  DOI: 10.1126/sciadv.adf4975
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10284557/
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection

1
1. scibot 31 Dec 2022
  
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  RRID:Addgene_102597
  
  DOI: 10.1128/mbio.02446-22
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9765453/
Oct 2022
journals.asm.org journals.asm.org

Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection

1
1. scibot 25 Oct 2022
  
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  RRID:Addgene_102597
  
  DOI: 10.1128/mbio.02446-22
  
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journals.asm.org/doi/10.1128/mbio.02446-22
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing

1
1. scibot 28 Mar 2021
  
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  plasmid_102597
  
  DOI: 10.3390/v13030367
  
  Resource: RRID:Addgene_102597
  
  Curator: @evieth
  
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  RRID:Addgene_102597 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7996929/
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes

1
1. scibot 29 Oct 2020
  
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  RRID:Addgene_102597
  
  DOI: 10.3389/fcell.2020.583115
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_102597
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pubmed.ncbi.nlm.nih.gov/33117810/