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Aug 2026
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

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febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70438
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A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer

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sciencedirect.com/science/article/pii/S1535610826003120
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A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13411104/
Jul 2026
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LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

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54.241.53.176/0f38fc1e7fe7e28d4caf2728d0ad871f97ce0b85/jcs264977-html.html
Jun 2026
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Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome

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sciencedirect.com/science/article/pii/S2589004226017621
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SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

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sciencedirect.com/science/article/pii/S2211124726006224
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Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking

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pmc.ncbi.nlm.nih.gov/articles/PMC13196766/
Apr 2026
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Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes

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sciencedirect.com/science/article/pii/S2211124726003062
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Lysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growth

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pmc.ncbi.nlm.nih.gov/articles/PMC13031131/
Mar 2026
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Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors

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sciencedirect.com/science/article/pii/S2666379126001126
Jan 2026
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Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin‐Regulated Fashion

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pmc.ncbi.nlm.nih.gov/articles/PMC12828107/
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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  DOI: 10.1016/j.cell.2025.12.012
  
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sciencedirect.com/science/article/pii/S0092867425014254
Nov 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

A Clickable CoQ Imaging Probe reveals that Cellular Uptake and Lysosomal Trafficking depend on CD36 and NPC1

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sciencedirect.com:5037/science/article/pii/S2213231725004495
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MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

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nature.com/articles/s41556-025-01774-y
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Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis

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pmc.ncbi.nlm.nih.gov/articles/PMC12586712/
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JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation

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pmc.ncbi.nlm.nih.gov/articles/PMC12459091/
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

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pmc.ncbi.nlm.nih.gov/articles/PMC12439944/
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Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation

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pmc.ncbi.nlm.nih.gov/articles/PMC12605056/
Oct 2025
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Visualization of lysosomal membrane proteins by cryo electron tomography

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  DOI: 10.1038/s41467-025-64314-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12534608/
Sep 2025
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α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

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sciencedirect.com/science/article/pii/S1097276525007075
Aug 2025
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Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

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pmc.ncbi.nlm.nih.gov/articles/PMC12307602/
Jun 2025
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Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly

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pmc.ncbi.nlm.nih.gov/articles/PMC12117088/
May 2025
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Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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pmc.ncbi.nlm.nih.gov/articles/PMC11533445/
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The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC12031507/
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SLC7A11 is an unconventional H+ transporter in lysosomes

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sciencedirect.com/science/article/pii/S0092867425004064
Apr 2025
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RAF1 kinase contributes to autophagic lysosome reformation

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sciencedirect.com/science/article/pii/S221112472500261X
Mar 2025
rupress.org rupress.org

The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B

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rupress.org/jcb/article/224/5/e202407014/277317/The-deubiquitinase-USP45-inhibits-autophagy
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Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

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pmc.ncbi.nlm.nih.gov/articles/PMC10592882/
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

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52.53.155.43/6223e1a34d8b418f72131b1eba207b1427b70260/PDF-html.html
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Calcium signaling from damaged lysosomes induces cytoprotective stress granules

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pmc.ncbi.nlm.nih.gov/articles/PMC11649789/
Nov 2024
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Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

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sciencedirect.com/science/article/pii/S2211124724013366
Sep 2024
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
Aug 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy

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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2024.114619
  
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sciencedirect.com/science/article/pii/S2211124724009690
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Sestrin2 drives ER-phagy in response to protein misfolding

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sciencedirect.com/science/article/pii/S1534580724004416
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells

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1. scibot 07 Jul 2024
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.xpro.2024.103121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11215108/
Jun 2024
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Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

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1. scibot 30 Jun 2024
  
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  102930
  
  DOI: 10.1101/2024.04.02.587808
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11188082/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9

1
1. scibot 21 Jun 2024
  
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  plasmid_102930
  
  DOI: 10.21203/rs.3.rs-4413958/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11160916/
May 2024
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Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE

1
1. scibot 19 May 2024
  
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  plasmid_102
  
  DOI: 10.1186/s12967-024-05275-8
  
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  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11089807/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes

1
1. scibot 14 Apr 2024
  
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  Addgene_102930
  
  DOI: 10.1101/2024.03.21.586175
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983895/
Feb 2024
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DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy

1
1. scibot 05 Feb 2024
  
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  Addgene_102930
  
  DOI: 10.1038/s41467-024-44957-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830484/
Oct 2023
www.biorxiv.org www.biorxiv.org

Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

1
1. scibot 14 Oct 2023
  
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  RRID:Addgene_102930
  
  DOI: 10.1101/2023.09.11.557213
  
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biorxiv.org/content/10.1101/2023.09.11.557213v1
Sep 2023
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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

1
1. scibot 01 Sep 2023
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2023.113042
  
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sciencedirect.com/science/article/pii/S2211124723010537
Jul 2023
www.embopress.org www.embopress.org

An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes

1
1. scibot 05 Jul 2023
  
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  RRID:Addgene_102930
  
  DOI: 10.15252/embr.202356841
  
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embopress.org/doi/10.15252/embr.202356841
Apr 2023
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

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1. scibot 13 Apr 2023
  
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  Addgene_102930
  
  DOI: 10.1016/j.devcel.2023.03.014
  
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sciencedirect.com/science/article/pii/S1534580723001302
Jan 2023
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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

1
1. scibot 27 Jan 2023
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2023.112037
  
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sciencedirect.com/science/article/pii/S2211124723000487
Jul 2022
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Rapid macropinocytic transfer of α-synuclein to lysosomes

1
1. scibot 27 Jul 2022
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2022.111102
  
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sciencedirect.com/science/article/pii/S2211124722009044
Feb 2022
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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

1
1. scibot 16 Feb 2022
  
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  Addgene RRID: 102930
  
  DOI: 10.1016/j.celrep.2022.110365
  
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sciencedirect.com/science/article/pii/S2211124722000869
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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

1
1. scibot 04 Feb 2022
  
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  AddgeneCat# 102930
  
  DOI: 10.1016/j.molcel.2022.01.002
  
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sciencedirect.com/science/article/pii/S1097276522000028
Aug 2021
www.nature.com www.nature.com

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

1
1. scibot 17 Aug 2021
  
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  RRID:Addgene_102930
  
  DOI: 10.1038/s41467-021-25145-x
  
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nature.com/articles/s41467-021-25145-x
Jan 2020
elifesciences.org elifesciences.org

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

1
1. scibot 13 Jan 2020
  
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  Addgene_102930
  
  DOI: 10.7554/eLife.48363
  
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  RRID:Addgene_102930 RRIDCUR:Validated
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elifesciences.org/articles/48363