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Nov 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

A Clickable CoQ Imaging Probe reveals that Cellular Uptake and Lysosomal Trafficking depend on CD36 and NPC1

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1. scibot 29 Nov 2025
  
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  Addgene_102930
  
  DOI: 10.1016/j.redox.2025.103936
  
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sciencedirect.com:5037/science/article/pii/S2213231725004495
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

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1. scibot 24 Nov 2025
  
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  DOI: 10.1038/s41556-025-01774-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12527936/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis

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1. scibot 24 Nov 2025
  
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  Addgene_102930
  
  DOI: 10.1038/s41419-025-08164-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12586712/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation

1
1. scibot 23 Nov 2025
  
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  102930
  
  DOI: 10.1083/jcb.202404018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459091/
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation

1
1. scibot 23 Nov 2025
  
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  Addgene_102930
  
  DOI: 10.1101/2025.09.09.674968
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12439944/
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Mitochondrial cardiolipin remodeling facilitates efficient myoblast differentiation

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1016/j.jlr.2025.100909
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12605056/
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Visualization of lysosomal membrane proteins by cryo electron tomography

1
1. scibot 21 Oct 2025
  
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  DOI: 10.1038/s41467-025-64314-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12534608/
Sep 2025
www.sciencedirect.com www.sciencedirect.com

α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

2
1. scibot 11 Sep 2025
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.molcel.2025.08.022
  
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2. scibot 11 Sep 2025
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.molcel.2025.08.022
  
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sciencedirect.com/science/article/pii/S1097276525007075
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

1
1. scibot 11 Aug 2025
  
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  102930
  
  DOI: 10.1038/s41467-025-61894-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12307602/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly

1
1. scibot 15 Jun 2025
  
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  102930
  
  DOI: 10.1038/s41467-025-60277-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12117088/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

1
1. scibot 19 May 2025
  
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  RRID:Addgene_102930
  
  DOI: 10.1083/jcb.202403116
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11533445/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

1
1. scibot 17 May 2025
  
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  102930
  
  DOI: 10.3390/v17040522
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12031507/
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SLC7A11 is an unconventional H+ transporter in lysosomes

1
1. scibot 16 May 2025
  
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  Addgene102930
  
  DOI: 10.1016/j.cell.2025.04.004
  
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sciencedirect.com/science/article/pii/S0092867425004064
Apr 2025
www.sciencedirect.com www.sciencedirect.com

RAF1 kinase contributes to autophagic lysosome reformation

1
1. scibot 05 Apr 2025
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.celrep.2025.115490
  
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sciencedirect.com/science/article/pii/S221112472500261X
Mar 2025
rupress.org rupress.org

The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B

1
1. scibot 23 Mar 2025
  
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  102930
  
  DOI: 10.1083/jcb.202407014
  
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rupress.org/jcb/article/224/5/e202407014/277317/The-deubiquitinase-USP45-inhibits-autophagy
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

1
1. scibot 23 Mar 2025
  
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  Addgene_102930
  
  DOI: 10.1101/2023.10.02.560519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10592882/
Dec 2024
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 29 Dec 2024
  
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  https://www.addgene.org/102930/)
  
  DOI: 10.1172/jci183592
  
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52.53.155.43/6223e1a34d8b418f72131b1eba207b1427b70260/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Calcium signaling from damaged lysosomes induces cytoprotective stress granules

1
1. scibot 28 Dec 2024
  
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  Addgene_102930
  
  DOI: 10.1038/s44318-024-00292-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11649789/
Nov 2024
www.sciencedirect.com www.sciencedirect.com

Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

2
1. scibot 24 Nov 2024
  
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  RRID: Addgene_102930
  
  DOI: 10.1016/j.celrep.2024.114985
  
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2. scibot 24 Nov 2024
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.celrep.2024.114985
  
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sciencedirect.com/science/article/pii/S2211124724013366
Sep 2024
www.sciencedirect.com www.sciencedirect.com

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

1
1. scibot 12 Sep 2024
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

1
1. scibot 21 Aug 2024
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy

1
1. scibot 21 Aug 2024
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2024.114619
  
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sciencedirect.com/science/article/pii/S2211124724009690
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Sestrin2 drives ER-phagy in response to protein misfolding

1
1. scibot 18 Aug 2024
  
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  Addgene_102930
  
  DOI: 10.1016/j.devcel.2024.07.004
  
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sciencedirect.com/science/article/pii/S1534580724004416
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells

1
1. scibot 07 Jul 2024
  
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  RRID:Addgene_102930
  
  DOI: 10.1016/j.xpro.2024.103121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11215108/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2

1
1. scibot 30 Jun 2024
  
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  102930
  
  DOI: 10.1101/2024.04.02.587808
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11188082/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9

1
1. scibot 21 Jun 2024
  
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  plasmid_102930
  
  DOI: 10.21203/rs.3.rs-4413958/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11160916/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE

1
1. scibot 19 May 2024
  
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  plasmid_102
  
  DOI: 10.1186/s12967-024-05275-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11089807/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes

1
1. scibot 14 Apr 2024
  
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  Addgene_102930
  
  DOI: 10.1101/2024.03.21.586175
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983895/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy

1
1. scibot 05 Feb 2024
  
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  Addgene_102930
  
  DOI: 10.1038/s41467-024-44957-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830484/
Oct 2023
www.biorxiv.org www.biorxiv.org

Parkinson’s genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

1
1. scibot 14 Oct 2023
  
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  RRID:Addgene_102930
  
  DOI: 10.1101/2023.09.11.557213
  
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biorxiv.org/content/10.1101/2023.09.11.557213v1
Sep 2023
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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

1
1. scibot 01 Sep 2023
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2023.113042
  
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sciencedirect.com/science/article/pii/S2211124723010537
Jul 2023
www.embopress.org www.embopress.org

An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes

1
1. scibot 05 Jul 2023
  
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  RRID:Addgene_102930
  
  DOI: 10.15252/embr.202356841
  
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embopress.org/doi/10.15252/embr.202356841
Apr 2023
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

1
1. scibot 13 Apr 2023
  
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  Addgene_102930
  
  DOI: 10.1016/j.devcel.2023.03.014
  
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sciencedirect.com/science/article/pii/S1534580723001302
Jan 2023
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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

1
1. scibot 27 Jan 2023
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2023.112037
  
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sciencedirect.com/science/article/pii/S2211124723000487
Jul 2022
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Rapid macropinocytic transfer of α-synuclein to lysosomes

1
1. scibot 27 Jul 2022
  
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  plasmid_102930
  
  DOI: 10.1016/j.celrep.2022.111102
  
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sciencedirect.com/science/article/pii/S2211124722009044
Feb 2022
www.sciencedirect.com www.sciencedirect.com

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

1
1. scibot 16 Feb 2022
  
  in Public
  
  Addgene RRID: 102930
  
  DOI: 10.1016/j.celrep.2022.110365
  
  Resource: RRID:Addgene_102930
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_102930
  
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  RRID:Addgene_102930
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scibot

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sciencedirect.com/science/article/pii/S2211124722000869
www.sciencedirect.com www.sciencedirect.com

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

1
1. scibot 04 Feb 2022
  
  in Public
  
  AddgeneCat# 102930
  
  DOI: 10.1016/j.molcel.2022.01.002
  
  Resource: RRID:Addgene_102930
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_102930
  
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  RRID:Addgene_102930
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URL

sciencedirect.com/science/article/pii/S1097276522000028
Aug 2021
www.nature.com www.nature.com

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

1
1. scibot 17 Aug 2021
  
  in Public
  
  RRID:Addgene_102930
  
  DOI: 10.1038/s41467-021-25145-x
  
  Resource: RRID:Addgene_102930
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_102930
  
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  RRID:Addgene_102930
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nature.com/articles/s41467-021-25145-x
Jan 2020
elifesciences.org elifesciences.org

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

1
1. scibot 13 Jan 2020
  
  in Public
  
  Addgene_102930
  
  DOI: 10.7554/eLife.48363
  
  Resource: RRID:Addgene_102930
  
  Curator: @Naa003
  
  SciCrunch record: Addgene_102930
  
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  RRID:Addgene_102930 RRIDCUR:Validated
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URL

elifesciences.org/articles/48363