99 Matching Annotations
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    Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model
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    Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel–Kreienkamp syndrome
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    Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration
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  5. Nov 2025
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    A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system
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    Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
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    Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy
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  9. Oct 2025
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    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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  11. Aug 2025
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    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses
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    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    A sensitive orange fluorescent calcium ion indicator for imaging neural activity
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  17. Jul 2025
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    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    PP2Acα regulates sleep amount and sleep homeostasis in mice
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    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
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    elifesciences.org/reviewed-preprints/107556
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    Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity
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  22. Jun 2025
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    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
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  25. May 2025
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    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    Machine learning identification of enhancers in the rhesus macaque genome
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    Specific targeting of brain endothelial cells using enhancer AAV vectors
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    A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
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    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
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    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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  32. Apr 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Staufen2 dysregulation in neurodegenerative disease
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  34. Mar 2025
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    Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
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    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    Extensive length and homology dependent chimerism in pool-packaged AAV libraries
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  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome
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  39. Feb 2025
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis
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    Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
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  43. Jan 2025
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    An engineered adeno-associated virus mediates efficient blood-brain barrier penetration with enhanced neurotropism and reduced hepatotropism
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  45. Dec 2024
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
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    Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice
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  49. Sep 2024
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    Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
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    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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  54. Aug 2024
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    Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
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    An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels
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    Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
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    Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
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  60. Jun 2024
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  62. May 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A multicolor suite for deciphering population coding of calcium and cAMP in vivo
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    Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
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    Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells
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    Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno‐associated virus vectors expressing human P301L tau
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  68. Apr 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke
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  70. Mar 2024
  71. www.biorxiv.org www.biorxiv.org
    Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
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  73. Feb 2024
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    Oxidized SOD1 accelerates cellular senescence in neural stem cells
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    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves
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  77. Dec 2023
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    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
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    biorxiv.org/content/10.1101/2020.03.31.016972v2
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    Creation of de novo cryptic splicing for ALS/FTD precision medicine
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  81. Nov 2023
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    ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging
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    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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    Dopamine pathways mediating affective state transitions after sleep loss
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    An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains
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  86. Aug 2023
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KMT2C knockout generates ASD-like behaviors in mice
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  88. Jul 2023
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    Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
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    Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
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    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10332811/
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    Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
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  93. Jun 2023
  94. www.biorxiv.org www.biorxiv.org
    Scalable, cell type-selective in vivo AAV-based CRISPR screens in mice
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    KMT2C knockout generates ASD-like behaviors in mice
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    biorxiv.org/content/10.1101/2023.05.26.542423v1
  96. May 2023
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    Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome
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  98. Mar 2023
  99. europepmc.org europepmc.org
    ER proteostasis regulators cell-non-autonomously control sleep
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    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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    biorxiv.org/content/10.1101/2023.02.21.529451v1
  101. Feb 2023
  102. www.nature.com www.nature.com
    An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice
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  103. Jan 2023
  104. www.biorxiv.org www.biorxiv.org
    Neuronal expression of herpes simplex virus type-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation by activating Jun
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    biorxiv.org/content/10.1101/2023.01.13.524029v1
  105. Jun 2022
  106. www.sciencedirect.com www.sciencedirect.com
    Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina
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  107. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Single-Cell Quantification of Triple-AAV Vector Genomes Coexpressed in Neurons
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    currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.430
  108. Nov 2021
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    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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    Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology
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    ncbi.nlm.nih.gov/pmc/articles/PMC8549541/
  111. Oct 2021
  112. www.nature.com www.nature.com
    Comparative cellular analysis of motor cortex in human, marmoset and mouse
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    nature.com/articles/s41586-021-03465-8
  113. Sep 2021
  114. www.sciencedirect.com www.sciencedirect.com
    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors
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    Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8417311/
  117. Aug 2021
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    Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
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    sciencedirect.com/science/article/pii/S2211124721009220
  119. Jul 2021
  120. www.sciencedirect.com www.sciencedirect.com
    GABA-receptive microglia selectively sculpt developing inhibitory circuits
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    sciencedirect.com/science/article/pii/S0092867421007534
  121. May 2021
  122. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
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    pubmed.ncbi.nlm.nih.gov/33960685/
  123. www.sciencedirect.com www.sciencedirect.com
    Enhancer viruses for combinatorial cell-subclass-specific labeling
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    sciencedirect.com/science/article/pii/S0896627321001598
  124. Feb 2021
  125. www.frontiersin.org www.frontiersin.org
    Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness
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    frontiersin.org/article/10.3389/fnmol.2020.600051/full
  126. www.nature.com www.nature.com
    Viral rhodopsins 1 are an unique family of light-gated cation channels
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    nature.com/articles/s41467-020-19457-7
  127. Dec 2020
  128. www.jneurosci.org www.jneurosci.org
    Cell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice
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    jneurosci.org/content/40/50/9772
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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    ncbi.nlm.nih.gov/pmc/articles/PMC7683292/
  130. Sep 2020
  131. www.sciencedirect.com www.sciencedirect.com
    Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution
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  132. Jan 2020
  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6819083/