124 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12987736/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871359/
  4. Oct 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DREAMS illuminates spatial DNA and RNA modification landscapes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13561862/
  6. Sep 2026
  7. www.sciencedirect.com www.sciencedirect.com
    Mapping cell-type- and age-dependent neuronal vulnerability through genome-wide in vivo CRISPRi screens in the mouse brain
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    sciencedirect.com/science/article/pii/S089662732600615X
  8. Aug 2026
  9. www.sciencedirect.com www.sciencedirect.com
    CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice
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    sciencedirect.com/science/article/pii/S2589004226027197
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    Pleiotrophin regulates presynaptic assembly and function through heparan sulfate-dependent binding to neurexin1
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    sciencedirect.com/science/article/pii/S2211124726009058
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Monitoring in vivo transcription with synthetic serum markers
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    pmc.ncbi.nlm.nih.gov/articles/PMC13388719/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rapid neuronal labeling and functional imaging in the developing mouse brain with AAV-PHP.eB
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    pmc.ncbi.nlm.nih.gov/articles/PMC13390054/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A sensitive orange fluorescent calcium ion indicator for imaging neural activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13438757/
  14. Jul 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC13354796/
  16. Jun 2026
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sphingosine-1-Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex
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    onlinelibrary.wiley.com/doi/10.1002/glia.70177
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142468/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetically encoded assembly recorder temporally resolves cellular history
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    pmc.ncbi.nlm.nih.gov/articles/PMC13102709/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Computationally guided discovery of Ly6e/LY6E-dependent AAV capsid variants
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    pmc.ncbi.nlm.nih.gov/articles/PMC13101293/
  21. May 2026
  22. www.sciencedirect.com www.sciencedirect.com
    Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics
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    sciencedirect.com/science/article/pii/S266637912600217X
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142468/
  24. Apr 2026
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Receptor-guided AAV Tropism Engineering via MATCH
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    pmc.ncbi.nlm.nih.gov/articles/PMC13060145/
  26. www.biorxiv.org www.biorxiv.org
    Sphingosine-1-Phosphate Receptor 1 regulates competition dependent astrocyte morphogenesis and tiling in murine cortex
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    biorxiv.org/content/10.64898/2026.03.28.714989v2
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Viral vector-mediated SLC9A6 gene replacement reduces cerebellar motor and molecular abnormalities in the shaker rat model of Christianson syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC13050144/
  28. www.nature.com www.nature.com
    UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration
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    nature.com/articles/s41593-026-02226-y
  29. Feb 2026
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mosaic AAV mediates efficient transduction across the central and peripheral nervous systems
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859846/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12802539/
  32. Jan 2026
  33. www.sciencedirect.com www.sciencedirect.com
    AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy
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    sciencedirect.com/science/article/pii/S0092867425014886
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted deletion of EMMPRIN in microglia/macrophages mitigates neuronal death in intracerebral hemorrhage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12817446/
  35. Nov 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of IRAK1/TAK1 signaling in astrocytes reduces accelerated mortality in human APOE4 knock-in APPswe/PSEN1dE9/P301S-Tau triple transgenic mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12542347/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel–Kreienkamp syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12529666/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12559333/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12486091/
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    Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
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    nature.com/articles/s41467-025-65487-4
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12588532/
  42. Oct 2025
  43. www.biorxiv.org www.biorxiv.org
    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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    biorxiv.org/content/10.1101/2025.10.14.682478v1
  44. Aug 2025
  45. www.nature.com www.nature.com
    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    nature.com/articles/s41593-025-02043-9
  46. www.biorxiv.org www.biorxiv.org
    Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses
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    biorxiv.org/content/10.1101/2025.08.19.671016v1
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11780352/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225013811-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329260/
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    A sensitive orange fluorescent calcium ion indicator for imaging neural activity
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    biorxiv.org/content/10.1101/2025.07.28.667269v1
  50. Jul 2025
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PP2Acα regulates sleep amount and sleep homeostasis in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238387/
  53. elifesciences.org elifesciences.org
    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
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    elifesciences.org/reviewed-preprints/107556
  54. www.biorxiv.org www.biorxiv.org
    Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity
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    biorxiv.org/content/10.1101/2025.06.20.660790v1
  55. Jun 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185343/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132946/
  58. May 2025
  59. www.sciencedirect.com www.sciencedirect.com
    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627325003459
  60. www.sciencedirect.com www.sciencedirect.com
    Machine learning identification of enhancers in the rhesus macaque genome
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    sciencedirect.com/science/article/pii/S0896627325003137
  61. www.sciencedirect.com www.sciencedirect.com
    Specific targeting of brain endothelial cells using enhancer AAV vectors
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    sciencedirect.com/science/article/pii/S089662732500251X
  62. www.sciencedirect.com www.sciencedirect.com
    A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
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    sciencedirect.com/science/article/pii/S0092867425005136
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050299/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  65. Apr 2025
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Staufen2 dysregulation in neurodegenerative disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11938042/
  67. Mar 2025
  68. www.nature.com www.nature.com
    Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
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    nature.com/articles/s41587-025-02565-4
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766445/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extensive length and homology dependent chimerism in pool-packaged AAV libraries
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761685/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11760745/
  72. Feb 2025
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842818/
  74. www.sciencedirect.com www.sciencedirect.com
    IL-16 exerts anti-rabies virus effects through CD9 on the surface of viral particles
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    sciencedirect.com/science/article/pii/S0141813025015910
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789068/
  76. Jan 2025
  77. www.sciencedirect.com www.sciencedirect.com
    An engineered adeno-associated virus mediates efficient blood-brain barrier penetration with enhanced neurotropism and reduced hepatotropism
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    sciencedirect.com/science/article/pii/S0168365925000240
  78. Dec 2024
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668525/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11264692/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11603655/
  82. Sep 2024
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11258272/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343251/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple and highly specific targeting of resident microglia with adeno-associated virus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407971/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of KDM6B mosaic brain knockout on synaptic function and behavior
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369245/
  87. Aug 2024
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11316102/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell discovery of m6A RNA modifications in the hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293556/
  90. rupress.org rupress.org
    An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels
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    rupress.org/jcb/article/223/10/e202401140/276880/An-evolutionarily-conserved-AnkyrinG-dependent
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269569/
  92. www.cell.com www.cell.com
    Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
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    cell.com/cell-reports/fulltext/S2211-1247(24)00756-3
  93. Jun 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering viral vectors for acoustically targeted gene delivery
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    ncbi.nlm.nih.gov/pmc/articles/PMC11164914/
  95. May 2024
  96. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A multicolor suite for deciphering population coding of calcium and cAMP in vivo
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
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    ncbi.nlm.nih.gov/pmc/articles/PMC11070337/
  98. www.sciencedirect.com www.sciencedirect.com
    Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
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    sciencedirect.com/science/article/pii/S2666379124002386
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042220/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of tauopathy in a mouse model of amyloidosis using intravenous administration of adeno‐associated virus vectors expressing human P301L tau
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    ncbi.nlm.nih.gov/pmc/articles/PMC11058624/
  101. Apr 2024
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034579/
  103. Mar 2024
  104. www.biorxiv.org www.biorxiv.org
    Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
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    biorxiv.org/content/10.1101/2024.03.20.585910v1
  105. www.sciencedirect.com www.sciencedirect.com
    Type-I-interferon-responsive microglia shape cortical development and behavior
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    sciencedirect.com/science/article/pii/S0092867424001867
  106. Feb 2024
  107. link.springer.com link.springer.com
    Oxidized SOD1 accelerates cellular senescence in neural stem cells
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    link.springer.com/article/10.1186/s13287-024-03669-5
  108. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    biorxiv.org/content/10.1101/2023.12.21.572751v1
  109. www.sciencedirect.com www.sciencedirect.com
    Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves
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    sciencedirect.com/science/article/pii/S2211124724000810
  110. Dec 2023
  111. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
  112. www.biorxiv.org www.biorxiv.org
    Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse
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    biorxiv.org/content/10.1101/2020.03.31.016972v2
  113. www.biorxiv.org www.biorxiv.org
    Creation of de novo cryptic splicing for ALS/FTD precision medicine
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    biorxiv.org/content/10.1101/2023.11.15.565967v1
  114. Nov 2023
  115. www.sciencedirect.com www.sciencedirect.com
    ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging
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    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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    Dopamine pathways mediating affective state transitions after sleep loss
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  119. Aug 2023
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  121. Jul 2023
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    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
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    Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis
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  126. Jun 2023
  127. www.biorxiv.org www.biorxiv.org
    Scalable, cell type-selective in vivo AAV-based CRISPR screens in mice
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  129. May 2023
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    Histological Analysis of a Mouse Model of the 22q11.2 Microdeletion Syndrome
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  131. Mar 2023
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    A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
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  134. Feb 2023
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    An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice
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  136. Jan 2023
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    Neuronal expression of herpes simplex virus type-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation by activating Jun
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  138. Jun 2022
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    Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina
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  141. Nov 2021
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    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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  144. Oct 2021
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  146. Sep 2021
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    Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors
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    Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model
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  150. Aug 2021
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    Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
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  152. Jul 2021
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  154. May 2021
  155. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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  157. Feb 2021
  158. www.frontiersin.org www.frontiersin.org
    Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness
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  160. Dec 2020
  161. www.jneurosci.org www.jneurosci.org
    Cell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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  163. Sep 2020
  164. www.sciencedirect.com www.sciencedirect.com
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  165. Jan 2020
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    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1
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