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Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Engineered virus-like particle-assembled Vegfa-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration

1
1. scibot 24 Nov 2025
  
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  104174
  
  DOI: 10.1186/s13059-025-03774-5
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12509411/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9

1
1. scibot 06 Sep 2025
  
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  104174
  
  DOI: 10.1016/j.omtn.2025.102677
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12410342/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

1
1. scibot 10 Aug 2025
  
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  104174
  
  DOI: 10.1038/s41467-025-62562-8
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12325647/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A rational engineering strategy for structural dynamics modulation enables target specificity enhancement of the Cas9 nuclease

1
1. scibot 20 Jul 2025
  
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  104174
  
  DOI: 10.1093/nar/gkaf535
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12204706/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tumor-promoting UBR4 coordinates impaired mitophagy–associated senescence and lung adenocarcinoma pathogenesis

1
1. scibot 20 Jul 2025
  
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  104174
  
  DOI: 10.1073/pnas.2425015122
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12207436/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Establishment and rescue of fibroblast cell lines carrying a nonsense mutation of RB1 by CRISPR-based base editing

1
1. scibot 20 Jul 2025
  
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  104174
  
  DOI: 10.1038/s41598-025-10600-2
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12254293/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Effects of heterozygous SMG1 mutations on nonsense-mediated mRNA decay in human pluripotent stem cell model

1
1. scibot 20 Jul 2025
  
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  104174
  
  DOI: 10.1016/j.mocell.2025.100225
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12173119/
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Functional assessment of all ATM SNVs using prime editing and deep learning

1
1. scibot 28 Jun 2025
  
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  Addgene_104174
  
  DOI: 10.1016/j.cell.2025.05.046
  
  Resource: RRID:Addgene_104174
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867425006348
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Autophagy induction enhances homologous recombination-associated CRISPR–Cas9 gene editing

1
1. scibot 16 May 2025
  
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  104174
  
  DOI: 10.1093/nar/gkaf258
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997770/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An innovative approach using CRISPR-ribonucleoprotein packaged in virus-like particles to generate genetically engineered mouse models

1
1. scibot 16 May 2025
  
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  104174
  
  DOI: 10.1038/s41467-025-58364-7
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_104174
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11992299/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

AMPK activation by glycogen expenditure primes the exit of naïve pluripotency

1
1. scibot 07 Apr 2025
  
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  Addgene_104174
  
  DOI: 10.1038/s44319-025-00384-x
  
  Resource: RRID:Addgene_104174
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11933299/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Guide for generating single-cell–derived knockout clones in mammalian cell lines using the CRISPR/Cas9 system

1
1. scibot 26 Aug 2024
  
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  Addgene_104174
  
  DOI: 10.1016/j.mocell.2024.100087
  
  Resource: RRID:Addgene_104174
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292505/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Early Developmental Characteristics and Features of a Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis

1
1. scibot 17 Aug 2024
  
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  104174
  
  DOI: 10.3390/ijms25158203
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11311801/
Feb 2024
www.biorxiv.org www.biorxiv.org

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

1
1. scibot 09 Feb 2024
  
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  Addgene_104174
  
  DOI: 10.1101/2023.12.03.569825
  
  Resource: RRID:Addgene_104174
  
  Curator: @scibot
  
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biorxiv.org/content/10.1101/2023.12.03.569825v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Highly efficient genome editing via CRISPR-Cas9 ribonucleoprotein (RNP) delivery in mesenchymal stem cells

1
1. scibot 04 Feb 2024
  
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  104174
  
  DOI: 10.5483/BMBRep.2023-0113
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10828435/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide in-locus epitope tagging of Arabidopsis proteins using prime editors

1
1. scibot 04 Feb 2024
  
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  104174
  
  DOI: 10.5483/BMBRep.2023-0055
  
  Resource: RRID:Addgene_104174
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10828436/
Sep 2023
www.nature.com www.nature.com

CRISPR prime editing for unconstrained correction of oncogenic KRAS variants

1
1. scibot 20 Sep 2023
  
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  104174
  
  DOI: 10.1038/s42003-023-05052-1
  
  Resource: RRID:Addgene_104174
  
  Curator: @bandrow
  
  SciCrunch record: RRID:Addgene_104174
  
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  RRID:Addgene_104174
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nature.com/articles/s42003-023-05052-1
May 2021
www.sciencedirect.com www.sciencedirect.com

Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease

1
1. scibot 05 May 2021
  
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  Addgene_104174
  
  DOI: 10.1016/j.stem.2021.04.010
  
  Resource: RRID:Addgene_104174
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_104174
  
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  RRID:Addgene_104174
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sciencedirect.com/science/article/pii/S1934590921001673