12 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC13155378/
  3. Jan 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains
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    sciencedirect.com/science/article/pii/S1097276525009839
  5. Jan 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742450/
  7. www.sciencedirect.com www.sciencedirect.com
    Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
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    sciencedirect.com/science/article/pii/S2211124724015560
  8. Dec 2024
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hydrogen–Deuterium Exchange Mass Spectrometry Reveals Mechanistic Insights into RNA Oligonucleotide-Mediated Inhibition of TDP-43 Aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11638948/
  10. Sep 2024
  11. www.nature.com www.nature.com
    Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS
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    nature.com/articles/s41467-024-52151-6
  12. Apr 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Seeding competent TDP-43 persists in human patient and mouse muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC11014586/
  14. Jul 2023
  15. www.embopress.org www.embopress.org
    Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns
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    embopress.org/doi/10.15252/embj.2022111719
  16. Apr 2023
  17. link.springer.com link.springer.com
    C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD
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    link.springer.com/article/10.1007/s00401-023-02565-1
  18. May 2022
  19. www.sciencedirect.com www.sciencedirect.com
    Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
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    sciencedirect.com/science/article/pii/S1097276522003859
  20. Aug 2021
  21. www.sciencedirect.com www.sciencedirect.com
    TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
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    sciencedirect.com/science/article/pii/S0092867421008771
  22. Dec 2020
  23. www.sciencedirect.com www.sciencedirect.com
    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
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    sciencedirect.com/science/article/pii/S2211124720315278