52 Matching Annotations
  1. Last 7 days
  2. www.science.org www.science.org
    mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation
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    science.org/doi/10.1126/sciadv.aee1905
  3. Aug 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues
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    pmc.ncbi.nlm.nih.gov/articles/PMC13401910/
  5. Jul 2026
  6. www.nature.com www.nature.com
    Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse
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    nature.com/articles/s41587-026-03184-3
  7. May 2026
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13148380/
  9. Apr 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC13015395/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The oncogenic potential of YAP requires Y357 phosphorylation in cholangiocytes but not in hepatocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12738621/
  12. Mar 2026
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012108/
  14. 54.241.53.176 54.241.53.176
    2026.03.09.710643.full-html.html
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    54.241.53.176/a51c42df6b8b294bc9cf9bac211564d122eddeef/2026.03.09.710643.full-html.html
  15. Dec 2025
  16. 54.241.53.176 54.241.53.176
    2025.12.06.692782.full-html.html
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    54.241.53.176/fbd0886bd2a440c71db224f7b73648e10705c43c/2025.12.06.692782.full-html.html
  17. Nov 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614225/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12552128/
  20. Sep 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte-to-cholangiocyte reprogramming
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    pmc.ncbi.nlm.nih.gov/articles/PMC12462609/
  22. Aug 2025
  23. www.biorxiv.org www.biorxiv.org
    SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte reprogramming into cholangiocyte lineage
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    biorxiv.org/content/10.1101/2025.08.15.670568v1
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial Sepsis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317418/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Perturb-Multimodal: a platform for pooled genetic screens with sequencing and imaging in intact mammalian tissue
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    pmc.ncbi.nlm.nih.gov/articles/PMC12324982/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury Through Suppressed JNK Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12324546/
  27. Jul 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FBP1 controls liver cancer evolution from senescent MASH hepatocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12168545/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198031/
  30. www.sciencedirect.com www.sciencedirect.com
    Liver CYP4A autophagic-lysosomal degradation (ALD): A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site
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    sciencedirect.com/science/article/pii/S0026895X25153212
  31. www.biorxiv.org www.biorxiv.org
    Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease
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    biorxiv.org/content/10.1101/2025.06.19.660551v1
  32. Jun 2025
  33. www.cell.com www.cell.com
    HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury
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    cell.com/cell-stem-cell/abstract/S1934-5909(25)00177-8
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12106947/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12165098/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12146743/
  37. May 2025
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
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    pmc.ncbi.nlm.nih.gov/articles/PMC12003176/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12000370/
  40. Mar 2025
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601512/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human-correlated genetic models identify precision therapy for liver cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11922762/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11781774/
  44. Jan 2025
  45. 52.53.155.43 52.53.155.43
    1-s2.0-S2352345X25000013-main-html.html
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    52.53.155.43/0005e2be0b8684777a17439912c3d1b3f3e96095/1-s2.0-S2352345X25000013-main-html.html
  46. Sep 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatocyte-specific EGFR deletion promotes fibrosis but has no effect on steatosis in fast food diet model of MASLD
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387264/
  48. Aug 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11325370/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11271484/
  51. Jun 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein
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    ncbi.nlm.nih.gov/pmc/articles/PMC11156938/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal decoding of human liver regeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC11153152/
  54. Apr 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-scale in vivo imaging of tumour development using a germline conditional triple-reporter system
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030518/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940201/
  57. Feb 2024
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1a
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    ncbi.nlm.nih.gov/pmc/articles/PMC10872697/
  59. Sep 2023
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10518627/
  61. Apr 2023
  62. www.sciencedirect.com www.sciencedirect.com
    Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages
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    sciencedirect.com/science/article/pii/S2211124723004266
  63. Apr 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
    2
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    sciencedirect.com/science/article/pii/S1550413122000936
  65. Jan 2022
  66. www.nature.com www.nature.com
    RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
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    nature.com/articles/s41467-021-27923-z
  67. Nov 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
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    sciencedirect.com/science/article/pii/S221112472101411X
  69. Apr 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
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    sciencedirect.com/science/article/pii/S1535610821001707
  71. Mar 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
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    sciencedirect.com/science/article/pii/S221112472100187X
  73. Feb 2021
  74. insight.jci.org insight.jci.org
    Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling
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    insight.jci.org/articles/view/141217
  75. Jan 2021
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
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    ncbi.nlm.nih.gov/pmc/articles/PMC7778269/
  77. Sep 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
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    sciencedirect.com/science/article/pii/S155041312030125X