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Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse

1
1. scibot 22 Jul 2026
  
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  Addgene, 107787
  
  DOI: 10.1038/s41587-026-03184-3
  
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nature.com/articles/s41587-026-03184-3
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response

1
1. scibot 09 May 2026
  
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  RRID:Addgene_107787
  
  DOI: 10.1093/g3journal/jkag047
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13148380/
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in mice

1
1. scibot 08 Apr 2026
  
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  107787
  
  DOI: 10.64898/2026.02.25.707976
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13015395/
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The oncogenic potential of YAP requires Y357 phosphorylation in cholangiocytes but not in hepatocytes

1
1. scibot 01 Apr 2026
  
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  RRID:Addgene_107787
  
  DOI: 10.1007/s13402-025-01133-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12738621/
Mar 2026
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Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK

1
1. scibot 26 Mar 2026
  
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  RRID:Addgene_107787
  
  DOI: 10.1073/pnas.2527162123
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13012108/
54.241.53.176 54.241.53.176

2026.03.09.710643.full-html.html

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1. scibot 19 Mar 2026
  
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  Addgene_107787
  
  DOI: 10.64898/2026.03.09.710643
  
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54.241.53.176/a51c42df6b8b294bc9cf9bac211564d122eddeef/2026.03.09.710643.full-html.html
Dec 2025
54.241.53.176 54.241.53.176

2025.12.06.692782.full-html.html

1
1. scibot 23 Dec 2025
  
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  107787
  
  DOI: 10.64898/2025.12.06.692782
  
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54.241.53.176/fbd0886bd2a440c71db224f7b73648e10705c43c/2025.12.06.692782.full-html.html
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice

1
1. scibot 24 Nov 2025
  
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  107787
  
  DOI: 10.1093/toxsci/kfaf151
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12614225/
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A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis

1
1. scibot 23 Nov 2025
  
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  107787
  
  DOI: 10.1038/s42255-025-01355-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12552128/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte-to-cholangiocyte reprogramming

1
1. scibot 27 Sep 2025
  
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  RRID:Addgene_107787
  
  DOI: 10.1158/2767-9764.CRC-25-0172
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12462609/
Aug 2025
www.biorxiv.org www.biorxiv.org

SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte reprogramming into cholangiocyte lineage

1
1. scibot 27 Aug 2025
  
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  Addgene, 107787
  
  DOI: 10.1101/2025.08.15.670568
  
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biorxiv.org/content/10.1101/2025.08.15.670568v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial Sepsis

1
1. scibot 10 Aug 2025
  
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  107787
  
  DOI: 10.1016/j.jcmgh.2025.101550
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12317418/
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Perturb-Multimodal: a platform for pooled genetic screens with sequencing and imaging in intact mammalian tissue

1
1. scibot 10 Aug 2025
  
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  107787
  
  DOI: 10.1016/j.cell.2025.05.022
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12324982/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury Through Suppressed JNK Signaling

1
1. scibot 08 Aug 2025
  
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  107787
  
  DOI: 10.1101/2025.07.31.667940
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12324546/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FBP1 controls liver cancer evolution from senescent MASH hepatocytes

1
1. scibot 20 Jul 2025
  
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  107787
  
  DOI: 10.1038/s41586-024-08317-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12168545/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver

1
1. scibot 20 Jul 2025
  
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  107787
  
  DOI: 10.1016/j.jcmgh.2025.101480
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12198031/
www.sciencedirect.com www.sciencedirect.com

Liver CYP4A autophagic-lysosomal degradation (ALD): A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site

1
1. scibot 15 Jul 2025
  
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  RRID:Addgene_107787
  
  DOI: 10.1016/j.molpha.2025.100061
  
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sciencedirect.com/science/article/pii/S0026895X25153212
www.biorxiv.org www.biorxiv.org

Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease

1
1. scibot 01 Jul 2025
  
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  Addgene_107787
  
  DOI: 10.1101/2025.06.19.660551
  
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biorxiv.org/content/10.1101/2025.06.19.660551v1
Jun 2025
www.cell.com www.cell.com

HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury

1
1. scibot 24 Jun 2025
  
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  RRID:Addgene_107787
  
  DOI: 10.1016/j.stem.2025.04.010
  
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cell.com/cell-stem-cell/abstract/S1934-5909(25)00177-8
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis

1
1. scibot 15 Jun 2025
  
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  107787
  
  DOI: 10.14814/phy2.70381
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12106947/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

1
1. scibot 15 Jun 2025
  
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  Addgene_107
  
  DOI: 10.1002/advs.202417355
  
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  RRID:Addgene_107787 RRIDCUR:Incorrect RRIDCUR:Unresolved
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pmc.ncbi.nlm.nih.gov/articles/PMC12165098/
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Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate

1
1. scibot 14 Jun 2025
  
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  AAV8-TBG-Cre
  
  DOI: 10.1073/pnas.2505263122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12146743/
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

2
1. scibot 16 May 2025
  
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  107787
  
  DOI: 10.1038/s41586-025-08677-w
  
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2. scibot 16 May 2025
  
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  107787
  
  DOI: 10.1038/s41586-025-08677-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12003176/
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Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation

1
1. scibot 16 May 2025
  
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  107787
  
  DOI: 10.1038/s41467-025-58809-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12000370/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function

1
1. scibot 23 Mar 2025
  
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  107787
  
  DOI: 10.1101/2024.11.18.624217
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11601512/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Human-correlated genetic models identify precision therapy for liver cancer

1
1. scibot 23 Mar 2025
  
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  107787
  
  DOI: 10.1038/s41586-025-08585-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11922762/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury

1
1. scibot 11 Mar 2025
  
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  AAV.TBG.PI.Cre.rBG
  
  DOI: 10.1097/HC9.0000000000000636
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11781774/
Jan 2025
52.53.155.43 52.53.155.43

1-s2.0-S2352345X25000013-main-html.html

2
1. scibot 07 Jan 2025
  
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  Addgene_107787
  
  DOI: 10.1016/j.jcmgh.2025.101460
  
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2. scibot 07 Jan 2025
  
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  Addgene_107787
  
  DOI: 10.1016/j.jcmgh.2025.101460
  
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52.53.155.43/0005e2be0b8684777a17439912c3d1b3f3e96095/1-s2.0-S2352345X25000013-main-html.html
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hepatocyte-specific EGFR deletion promotes fibrosis but has no effect on steatosis in fast food diet model of MASLD

1
1. scibot 27 Sep 2024
  
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  107787
  
  DOI: 10.1016/j.jcmgh.2024.101380
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387264/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

1
1. scibot 26 Aug 2024
  
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  107787
  
  DOI: 10.1016/j.molmet.2024.101982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11325370/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

1
1. scibot 13 Aug 2024
  
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  107787
  
  DOI: 10.1038/s41467-024-50454-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11271484/
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein

1
1. scibot 09 Jun 2024
  
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  107787
  
  DOI: 10.1038/s41467-024-49224-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11156938/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multimodal decoding of human liver regeneration

1
1. scibot 09 Jun 2024
  
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  plasmid_107787
  
  DOI: 10.1038/s41586-024-07376-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11153152/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multi-scale in vivo imaging of tumour development using a germline conditional triple-reporter system

1
1. scibot 30 Apr 2024
  
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  Addgene_107787
  
  DOI: 10.21203/rs.3.rs-4196140/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11030518/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1

1
1. scibot 14 Apr 2024
  
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  Addgene_107787
  
  DOI: 10.1016/j.bbrc.2024.149655
  
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC10940201/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Modifications of the GH Axis Reveal Unique Sexually Dimorphic Liver Signatures for Lcn13, Asns, Hamp2, Hao2, and Pgc1a

1
1. scibot 21 Feb 2024
  
  in Public
  
  AAV.TBG.PI.Cre.rBG [AAV8]
  
  DOI: 10.1210/jendso/bvae015
  
  Resource: RRID:Addgene_107787
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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ncbi.nlm.nih.gov/pmc/articles/PMC10872697/
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma

1
1. scibot 28 Sep 2023
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1016/j.xcrm.2023.101188
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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ncbi.nlm.nih.gov/pmc/articles/PMC10518627/
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages

1
1. scibot 29 Apr 2023
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1016/j.celrep.2023.112415
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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sciencedirect.com/science/article/pii/S2211124723004266
Apr 2022
www.sciencedirect.com www.sciencedirect.com

Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure

2
1. scibot 07 Apr 2022
  
  in Public
  
  Addgene107787
  
  DOI: 10.1016/j.cmet.2022.03.005
  
  Resource: RRID:Addgene_107787
  
  Curator: @sophiastull
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
2. scibot 07 Apr 2022
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1016/j.cmet.2022.03.005
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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sciencedirect.com/science/article/pii/S1550413122000936
Jan 2022
www.nature.com www.nature.com

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

1
1. scibot 22 Jan 2022
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1038/s41467-021-27923-z
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
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  RRID:Addgene_107787
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nature.com/articles/s41467-021-27923-z
Nov 2021
www.sciencedirect.com www.sciencedirect.com

Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

1
1. scibot 03 Nov 2021
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1016/j.celrep.2021.109938
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
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  RRID:Addgene_107787
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sciencedirect.com/science/article/pii/S221112472101411X
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

1
1. scibot 30 Apr 2021
  
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  Addgene_107787
  
  DOI: 10.1016/j.ccell.2021.03.012
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1535610821001707
Mar 2021
www.sciencedirect.com www.sciencedirect.com

Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

1
1. scibot 18 Mar 2021
  
  in Public
  
  AAV.TBG.PI.Cre.rBG
  
  DOI: 10.1016/j.celrep.2021.108873
  
  Resource: RRID:Addgene_107787
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRIDCUR:Missing RRID:Addgene_107787
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RRIDCUR:Missing

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sciencedirect.com/science/article/pii/S221112472100187X
Feb 2021
insight.jci.org insight.jci.org

Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling

1
1. scibot 26 Feb 2021
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1172/jci.insight.141217
  
  Resource: RRID:Addgene_107787
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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insight.jci.org/articles/view/141217
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

1
1. scibot 13 Jan 2021
  
  in Public
  
  RRID:Addgene_107787
  
  DOI: 10.1101/gad.344556.120
  
  Resource: RRID:Addgene_107787
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787 RRIDCUR:Validated
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RRIDCUR:Validated

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ncbi.nlm.nih.gov/pmc/articles/PMC7778269/
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

1
1. scibot 04 Sep 2020
  
  in Public
  
  Addgene107787
  
  DOI: 10.1016/j.cmet.2020.03.010
  
  Resource: RRID:Addgene_107787
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_107787
  
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  RRID:Addgene_107787
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RRID:Addgene_107787

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sciencedirect.com/science/article/pii/S155041312030125X