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Integrative 3D genome and epigenomic analysis identifies TP53RK and SYBU as critical regulators of stemness and anti-tumor immunity in HCC

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1. scibot 10 Aug 2026
  
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  RRID: Addgene_108098
  
  DOI: 10.1016/j.celrep.2026.117797
  
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sciencedirect.com/science/article/pii/S2211124726008752
Jul 2026
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FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia

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1. scibot 03 Jul 2026
  
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  Addgene_108098
  
  DOI: 10.1038/s41375-026-03030-0
  
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nature.com/articles/s41375-026-03030-0
Jun 2026
ashpublications.org ashpublications.org

Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing

1
1. scibot 24 Jun 2026
  
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  Addgene, catalog no. 108098
  
  DOI: 10.1182/blood.2025030137
  
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ashpublications.org/blood/article/147/17/1999/565976/An-optimized-CRISPR-Cas12a-genome-wide-screen
Feb 2026
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CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples

1
1. scibot 27 Feb 2026
  
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  Addgene_108098
  
  DOI: 10.1016/j.molcel.2026.02.003
  
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sciencedirect.com/science/article/pii/S1097276526000985
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

1
1. scibot 30 Jan 2026
  
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  RRID:Addgene_108098
  
  DOI: 10.1158/2159-8290.CD-25-0919
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12848863/
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Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies

1
1. scibot 26 Jan 2026
  
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  108098
  
  DOI: 10.1158/2159-8290.CD-25-0299
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
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Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia

1
1. scibot 23 Jan 2026
  
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  Addgene_108098
  
  DOI: 10.1016/j.celrep.2025.116875
  
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sciencedirect.com/science/article/pii/S221112472501647X
Nov 2025
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In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

1
1. scibot 23 Nov 2025
  
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  108098
  
  DOI: 10.1101/2025.09.23.678127
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12485727/
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells

1
1. scibot 15 Jun 2025
  
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  108098
  
  DOI: 10.3390/ijms26104907
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12112730/
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Phosphoproteomics Reveals L1CAM-Associated Signaling Networks in High-Grade Serous Ovarian Carcinoma: Implications for Radioresistance and Tumorigenesis

2
1. scibot 15 Jun 2025
  
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  108098
  
  DOI: 10.3390/ijms26104585
  
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2. scibot 15 Jun 2025
  
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  Addgene_108098
  
  DOI: 10.3390/ijms26104585
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12111665/
May 2025
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

1
1. scibot 22 May 2025
  
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  Addgene #108098
  
  DOI: 10.1016/j.molcel.2025.04.026
  
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sciencedirect.com/science/article/pii/S1097276525004058
Mar 2025
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

1
1. scibot 29 Mar 2025
  
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  Addgene_108098
  
  DOI: 10.1016/j.celrep.2025.115462
  
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sciencedirect.com/science/article/pii/S2211124725002335
Aug 2024
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

1
1. scibot 20 Aug 2024
  
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  Addgene_108098
  
  DOI: 10.1016/j.cell.2024.07.018
  
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sciencedirect.com/science/article/pii/S0092867424007785
www.cell.com www.cell.com

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

1
1. scibot 02 Aug 2024
  
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  Addgene:108098
  
  DOI: 10.1016/j.molcel.2020.11.006
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30784-X
Jul 2024
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Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

1
1. scibot 25 Jul 2024
  
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  Plasmid_108098
  
  DOI: 10.1016/j.ccell.2024.06.006
  
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sciencedirect.com/science/article/pii/S1535610824002319
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy

1
1. scibot 03 Jun 2024
  
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  Addgene_108
  
  DOI: 10.1186/s12967-024-05235-2
  
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  Curator: @olekpark
  
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  RRIDCUR:Unresolved RRID:Addgene_108098
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ncbi.nlm.nih.gov/pmc/articles/PMC11138051/
May 2024
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Genetic dependencies associated with transcription factor activities in human cancer cell lines

1
1. scibot 01 May 2024
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.celrep.2024.114175
  
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sciencedirect.com/science/article/pii/S2211124724005035
Mar 2024
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IκBζ is a dual-use coactivator of NF-κB and POU transcription factors

2
1. scibot 08 Mar 2024
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.molcel.2024.01.007
  
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2. scibot 08 Mar 2024
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.molcel.2024.01.007
  
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sciencedirect.com/science/article/pii/S109727652400008X
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma

1
1. scibot 29 Feb 2024
  
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  plasmid_108098
  
  DOI: 10.1038/s41467-024-46048-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879147/
Dec 2023
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B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling

1
1. scibot 17 Dec 2023
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.ccell.2023.11.008
  
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sciencedirect.com/science/article/pii/S1535610823003999
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR

1
1. scibot 07 Sep 2023
  
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  Addgene_108098
  
  DOI: 10.1101/2023.07.28.550976
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10473727/
Oct 2022
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Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis

1
1. scibot 20 Oct 2022
  
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  Plasmid_108098
  
  DOI: 10.1016/j.celrep.2022.111514
  
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sciencedirect.com/science/article/pii/S221112472201364X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia

1
1. scibot 08 Oct 2022
  
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  Addgene:108098
  
  DOI: 10.1016/j.isci.2022.105139
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9526175/
Apr 2022
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

1
1. scibot 13 Apr 2022
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.immuni.2022.03.007
  
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sciencedirect.com/science/article/pii/S1074761322001303
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers

1
1. scibot 09 Mar 2022
  
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  Addgene_108098
  
  DOI: 10.1016/j.immuni.2022.02.004
  
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sciencedirect.com/science/article/pii/S107476132200084X
Feb 2022
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

1
1. scibot 23 Feb 2022
  
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  Addgene Cat# 108098
  
  DOI: 10.1016/j.molcel.2022.01.015
  
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  Curator: @sophiastull
  
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sciencedirect.com/science/article/pii/S1097276522000582
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DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

1
1. scibot 16 Feb 2022
  
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  Addgene_108098
  
  DOI: 10.1016/j.celrep.2022.110369
  
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sciencedirect.com/science/article/pii/S2211124722000900
Jan 2022
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SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

1
1. scibot 12 Jan 2022
  
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  plasmid_108098
  
  DOI: 10.1016/j.celrep.2021.110233
  
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sciencedirect.com/science/article/pii/S2211124721017423
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 11 Aug 2021
  
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  plasmid_108098
  
  DOI: 10.1016/j.celrep.2018.10.051
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
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ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 07 Aug 2021
  
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  Addgene:108098
  
  DOI: 10.1016/j.molcel.2021.07.018
  
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  RRID:Addgene_108098 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1097276521005876
Jul 2021
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Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

1
1. scibot 28 Jul 2021
  
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  LRG2.1
  
  DOI: 10.1016/j.molcel.2019.01.006
  
  Resource: RRID:Addgene_108098
  
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sciencedirect.com/science/article/pii/S1097276519300061
May 2021
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Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

1
1. scibot 09 May 2021
  
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  Addgene_108098
  
  DOI: 10.1016/j.stem.2020.12.005
  
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sciencedirect.com/science/article/pii/S1934590920305890
Mar 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

1
1. scibot 02 Mar 2021
  
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  RRID:Addgene_108098
  
  DOI: 10.7554/eLife.65905
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7886351/
Feb 2021
elifesciences.org elifesciences.org

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

1
1. scibot 24 Feb 2021
  
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  RRID:Addgene_108098
  
  DOI: 10.7554/eLife.61797
  
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  Curator: @evieth
  
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  RRID:Addgene_108098 RRIDCUR:Validated
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elifesciences.org/articles/61797
Sep 2020
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Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

1
1. scibot 12 Sep 2020
  
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  RRID:Addgene_108098
  
  DOI: 10.1016/j.devcel.2020.01.034
  
  Resource: RRID:Addgene_108098
  
  Curator: @ethanbadger
  
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  RRID:Addgene_108098 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1534580720300666