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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Multimodal control of Cas13d activity through domain insertion at an allosteric hotspot

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1. scibot 08 Aug 2026
  
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  Addgene_109049
  
  DOI: 10.1038/s41467-026-73645-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13396516/
Jul 2026
aacrjournals.org aacrjournals.org

Gut Microbiota-Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment

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1. scibot 11 Jul 2026
  
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  RRID:Addgene_109049
  
  DOI: 10.1158/0008-5472.CAN-24-4425
  
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aacrjournals.org/cancerres/article/85/21/4081/766747/Gut-Microbiota-Mediated-Bile-Acid-Metabolism
Apr 2026
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Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells

1
1. scibot 08 Apr 2026
  
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  109049
  
  DOI: 10.1172/JCI198264
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13038199/
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Autism spectrum disorder-associated Sema5A p.Arg676Cys drives Arf6/FE65 signaling and aberrant cell morphogenesis

1
1. scibot 29 Mar 2026
  
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  109,049
  
  DOI: 10.1038/s41598-026-39722-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13003097/
Jan 2026
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LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2

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1. scibot 26 Jan 2026
  
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  Addgene_109049
  
  DOI: 10.1038/s41467-025-67591-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12827430/
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease

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1. scibot 06 Sep 2025
  
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  109049
  
  DOI: 10.1084/jem.20242106
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12410336/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR/Cas13-Mediated Inhibition of EBNA1 for Suppression of Epstein–Barr Virus Transcripts and DNA Load in Nasopharyngeal Carcinoma Cells

1
1. scibot 11 Aug 2025
  
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  109049
  
  DOI: 10.3390/v17070899
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12299874/
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically

1
1. scibot 20 Jul 2025
  
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  109049
  
  DOI: 10.1371/journal.ppat.1013281
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12204619/
May 2025
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CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis

1
1. scibot 16 May 2025
  
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  109049
  
  DOI: 10.1186/s13578-025-01397-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12020200/
Apr 2025
www.sciencedirect.com www.sciencedirect.com

Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
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  Addgene_109049
  
  DOI: 10.1016/j.ccell.2025.03.027
  
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sciencedirect.com/science/article/pii/S153561082500128X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity

1
1. scibot 07 Apr 2025
  
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  109049
  
  DOI: 10.1038/s41467-025-58032-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11937597/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo

1
1. scibot 07 Apr 2025
  
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  Addgene_109049
  
  DOI: 10.1093/nar/gkaf213
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11925727/
Feb 2025
www.nature.com www.nature.com

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d

1
1. scibot 27 Feb 2025
  
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  RRID:Addgene_109049
  
  DOI: 10.1038/s41564-025-01935-7
  
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nature.com/articles/s41564-025-01935-7
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models

1
1. scibot 27 Jan 2025
  
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  109049
  
  DOI: 10.1186/s13024-024-00794-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11727607/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR-Cas13-mediated RNA editing in the silkworm Bombyx mori

1
1. scibot 27 Dec 2024
  
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  109049
  
  DOI: 10.24272/j.issn.2095-8137.2024.105
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11668950/
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR/CasRx-Mediated Knockdown of Rab7B Restores Incomplete Cell Shape Induced by Pelizaeus-Merzbacher Disease-Associated PLP1 p.Ala243Val

1
1. scibot 25 Sep 2024
  
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  109049
  
  DOI: 10.1177/26331055241276873
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11402064/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development

1
1. scibot 18 Aug 2024
  
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  109049
  
  DOI: 10.1038/s41467-024-51041-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11310423/
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair

1
1. scibot 19 May 2024
  
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  Addgene_109
  
  DOI: 10.1186/s12943-024-02021-y
  
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  RRID:Addgene_109049 RRIDCUR:Incorrect RRIDCUR:Unresolved
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ncbi.nlm.nih.gov/pmc/articles/PMC11094906/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape

1
1. scibot 29 Apr 2024
  
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  109049
  
  DOI: 10.3390/cimb46040194
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11049140/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase

1
1. scibot 23 Apr 2024
  
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  109049
  
  DOI: 10.1093/nar/gkae110
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11014266/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems

2
1. scibot 23 Apr 2024
  
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  109049
  
  DOI: 10.1038/s41467-024-47592-y
  
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2. scibot 23 Apr 2024
  
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  Addgene_109049
  
  DOI: 10.1038/s41467-024-47592-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11024104/
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription

2
1. scibot 11 Apr 2024
  
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  AddgeneCat# 109049
  
  DOI: 10.1016/j.molcel.2024.03.021
  
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2. scibot 11 Apr 2024
  
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  Addgene_109049
  
  DOI: 10.1016/j.molcel.2024.03.021
  
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sciencedirect.com/science/article/pii/S1097276524002314
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Knockdown of Kmt2d leads to growth impairment by activating the Akt/β-catenin signaling pathway

1
1. scibot 08 Mar 2024
  
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  plasmid_109049
  
  DOI: 10.1093/g3journal/jkad298
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10917512/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL

1
1. scibot 15 Feb 2024
  
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  109049
  
  DOI: 10.3390/ijms25031477
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10855129/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway

1
1. scibot 13 Feb 2024
  
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  109049
  
  DOI: 10.1007/s10565-024-09848-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10847192/
Dec 2023
www.sciencedirect.com www.sciencedirect.com

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

1
1. scibot 17 Dec 2023
  
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  Addgene_109049
  
  DOI: 10.1016/j.cels.2023.11.006
  
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sciencedirect.com/science/article/pii/S2405471223003290
May 2023
www.liebertpub.com www.liebertpub.com

Pan-Coronavirus CRISPR-CasRx Effector System Significantly Reduces Viable Titer in HCoV-OC43, HCoV-229E, and SARS-CoV-2

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1. scibot 06 May 2023
  
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  RRID:Addgene_109049
  
  DOI: 10.1089/crispr.2022.0095
  
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liebertpub.com/doi/10.1089/crispr.2022.0095
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells

1
1. scibot 17 Aug 2022
  
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  Addgene_109049
  
  DOI: 10.1016/j.celrep.2022.111226
  
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sciencedirect.com/science/article/pii/S2211124722010439
Mar 2022
www.nature.com www.nature.com

ADARs act as potent regulators of circular transcriptome in cancer

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1. scibot 26 Mar 2022
  
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  RRID:Addgene_109049
  
  DOI: 10.1038/s41467-022-29138-2
  
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nature.com/articles/s41467-022-29138-2
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Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms

2
1. scibot 09 Mar 2022
  
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  Addgene#109049
  
  DOI: 10.1016/j.celrep.2022.110476
  
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2. scibot 09 Mar 2022
  
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  Addgene_109049
  
  DOI: 10.1016/j.celrep.2022.110476
  
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sciencedirect.com/science/article/pii/S2211124722002091
May 2021
www.sciencedirect.com www.sciencedirect.com

CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos

1
1. scibot 05 May 2021
  
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  plasmid_109049
  
  DOI: 10.1016/j.devcel.2020.07.013
  
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sciencedirect.com/science/article/pii/S1534580720305876
Nov 2020
www.sciencedirect.com www.sciencedirect.com

Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

1
1. scibot 07 Nov 2020
  
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  Plasmid_109049
  
  DOI: 10.1016/j.celrep.2020.108350
  
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  RRID:Addgene_109049 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720313395