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Saikosaponin‑D triggers cancer cell death by targeting the PIM1/c-Myc axis to reprogram oncogenic alternative splicing

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1. scibot 24 Nov 2025
  
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  109053
  
  DOI: 10.1038/s41420-025-02729-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12501015/
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations

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1. scibot 23 Nov 2025
  
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  109053
  
  DOI: 10.1101/2025.03.21.644128
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974705/
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR/Cas13-Mediated Inhibition of EBNA1 for Suppression of Epstein–Barr Virus Transcripts and DNA Load in Nasopharyngeal Carcinoma Cells

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1. scibot 11 Aug 2025
  
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  109053
  
  DOI: 10.3390/v17070899
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12299874/
www.cell.com www.cell.com

Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system

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1. scibot 08 Aug 2025
  
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  Addgene_109053
  
  DOI: 10.1016/j.cels.2025.101351
  
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cell.com/cell-systems/fulltext/S2405-4712(25)00184-X
Jun 2025
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Ezetimibe Engineered L14-8 Suppresses Advanced Prostate Cancer by Activating PLK1/TP53-SAT1-Induced Ferroptosis

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1. scibot 22 Jun 2025
  
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  Addgene, 109053
  
  DOI: 10.1002/advs.202504192
  
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  Curator: @sjvitug
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202504192
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis

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1. scibot 16 May 2025
  
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  109053
  
  DOI: 10.1186/s13578-025-01397-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12020200/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

1-s2.0-S2589004225002937-main-html.html

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1. scibot 23 Mar 2025
  
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  109053
  
  DOI: 10.1016/j.isci.2025.112033
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914516/
Jan 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models

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1. scibot 27 Jan 2025
  
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  109053
  
  DOI: 10.1186/s13024-024-00794-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11727607/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRISPR-Cas13-mediated RNA editing in the silkworm Bombyx mori

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1. scibot 27 Dec 2024
  
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  109053
  
  DOI: 10.24272/j.issn.2095-8137.2024.105
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11668950/
Jul 2024
www.sciencedirect.com www.sciencedirect.com

Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25

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1. scibot 24 Jul 2024
  
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  Addgene_109053
  
  DOI: 10.1016/j.molcel.2024.05.028
  
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sciencedirect.com/science/article/pii/S1097276524004751
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-dCas13d-based deep screening of proximal and distal splicing-regulatory elements

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1. scibot 12 May 2024
  
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  Addgene_109053
  
  DOI: 10.1038/s41467-024-47140-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11076525/
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway

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1. scibot 13 Feb 2024
  
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  109053
  
  DOI: 10.1007/s10565-024-09848-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10847192/
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction

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1. scibot 28 Dec 2023
  
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  RRID:Addgene_109053
  
  DOI: 10.1101/2023.12.05.570115
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10723268/
www.sciencedirect.com www.sciencedirect.com

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

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1. scibot 17 Dec 2023
  
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  Addgene_109053
  
  DOI: 10.1016/j.cels.2023.11.006
  
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sciencedirect.com/science/article/pii/S2405471223003290
May 2023
www.liebertpub.com www.liebertpub.com

Pan-Coronavirus CRISPR-CasRx Effector System Significantly Reduces Viable Titer in HCoV-OC43, HCoV-229E, and SARS-CoV-2

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1. scibot 06 May 2023
  
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  RRID:Addgene_109053
  
  DOI: 10.1089/crispr.2022.0095
  
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liebertpub.com/doi/10.1089/crispr.2022.0095
Dec 2022
journals.plos.org journals.plos.org

A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

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1. scibot 05 Dec 2022
  
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  RRID:Addgene_109053
  
  DOI: 10.1371/journal.pbio.3001885
  
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journals.plos.org/plosbiology/article
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells

1
1. scibot 17 Aug 2022
  
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  Addgene_109053
  
  DOI: 10.1016/j.celrep.2022.111226
  
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sciencedirect.com/science/article/pii/S2211124722010439
Jun 2022
www.mdpi.com www.mdpi.com

Evaluating the Impact of gRNA SNPs in CasRx Activity for Reducing Viral RNA in HCoV-OC43

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1. scibot 11 Jun 2022
  
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  RRID:Addgene_109053
  
  DOI: 10.3390/cells11121859
  
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mdpi.com/2073-4409/11/12/1859
Mar 2022
www.sciencedirect.com www.sciencedirect.com

Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex

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1. scibot 30 Mar 2022
  
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  RRID:Addgene_109053
  
  DOI: 10.1016/j.celrep.2022.110421
  
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sciencedirect.com/science/article/pii/S2211124722001450
www.nature.com www.nature.com

ADARs act as potent regulators of circular transcriptome in cancer

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1. scibot 26 Mar 2022
  
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  RRID:Addgene_109053
  
  DOI: 10.1038/s41467-022-29138-2
  
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nature.com/articles/s41467-022-29138-2