20 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2666379125004495
  3. Jun 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC12148233/
  5. Apr 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC11952967/
  7. Mar 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Massively parallel interrogation of human functional variants modulating cancer immunosurveillance
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC11920242/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC11866974/
  10. Feb 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimal SpCas9- and SaCas9-mediated gene editing by enhancing gRNA transcript levels through scaffold poly-T tract reduction
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC11823040/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced genome editing with a Streptococcus equinus Cas9
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    pmc.ncbi.nlm.nih.gov/articles/PMC11806022/
  13. Dec 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Mapping functional elements of the DNA damage response through base editor screens
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2211124724013986
  15. Sep 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Base editing of the GLB1 gene is therapeutic in GM1 gangliosidosis patient-derived cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S1096719224004529
  17. Jul 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11214518/
  19. Jun 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Susceptibility to innate immune activation in genetically mediated myocarditis
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11213508/
  21. May 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11116810/
  23. Apr 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC11040501/
  25. Mar 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC10978409/
  27. www.sciencedirect.com www.sciencedirect.com
    The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S0925443924001236
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC10896346/
  29. Sep 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    sciencedirect.com/science/article/pii/S2162253123002354
  31. Aug 2023
  32. 52.53.155.43 52.53.155.43
    One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
    2
    Visit annotations in context

    Tags

    Annotators

    URL

    52.53.155.43/6be832dffc5b1bbf8ca7ed6df051bba72a6ab6af/s41467-023-40701-3-html.html
  33. May 2022
  34. www.nature.com www.nature.com
    Saturation variant interpretation using CRISPR prime editing
    1
    Visit annotations in context

    Tags

    Annotators

    URL

    nature.com/articles/s41587-021-01201-1