59 Matching Annotations
  1. Jul 2026
  2. www.sciencedirect.com www.sciencedirect.com
    FGF21 synergizes with leptin to counteract obesity-related metabolic comorbidities by reversing hepatic leptin resistance
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    sciencedirect.com/science/article/pii/S1550413126002470
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection
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    pmc.ncbi.nlm.nih.gov/articles/PMC13183376/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acsl4-mediated Lipid Homeostasis Orchestrates Synaptic and Cognitive Plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142639/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export
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    pmc.ncbi.nlm.nih.gov/articles/PMC13226660/
  7. May 2026
  8. www.biorxiv.org www.biorxiv.org
    YY1 Binding Motif at Upstream of Rep/Cap Increases AAV Yield and Full Capsids
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    biorxiv.org/content/10.64898/2026.05.21.726733v1
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modelling kidney cystogenesis using human kidney tubuloid cultures
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    pmc.ncbi.nlm.nih.gov/articles/PMC13162504/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing
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    pmc.ncbi.nlm.nih.gov/articles/PMC13179063/
  11. www.sciencedirect.com www.sciencedirect.com
    Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics
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    sciencedirect.com/science/article/pii/S266637912600217X
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response
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    pmc.ncbi.nlm.nih.gov/articles/PMC13148380/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142468/
  14. Apr 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-cell omics reveals arg-1 as a key regulator of age-dependent macrophage-mediated cartilage repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC12974833/
  16. Feb 2026
  17. www.sciencedirect.com www.sciencedirect.com
    Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
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    sciencedirect.com/science/article/pii/S009286742600111X
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering of High‐Yield Recombinant Adeno‐Associated Virus Producer Plasmids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12802539/
  19. Nov 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554105/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12462433/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-22 Exacerbates Coxsackievirus Type B3-Induced Pancreatitis by Elevating Viral Replication Through STAT3 Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12599472/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623870/
  24. Sep 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410343/
  26. Aug 2025
  27. www.sciencedirect.com www.sciencedirect.com
    Hepatocyte metabolic adaptations during pregnancy and lactation
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    sciencedirect.com/science/article/pii/S0092867425009213
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265543/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained high expression of human FVII following AAV8-mediated gene delivery in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282199/
  30. Jul 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue
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    pmc.ncbi.nlm.nih.gov/articles/PMC12170882/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC12171320/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260061/
  34. 52.53.155.43 52.53.155.43
    matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
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    52.53.155.43/0eec343059498565fba813ed54e166140d5ee93f/matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
  35. www.journal-of-hepatology.eu www.journal-of-hepatology.eu
    Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
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    journal-of-hepatology.eu/article/S0168-8278(25)02320-7/fulltext
  36. Jun 2025
  37. www.sciencedirect.com www.sciencedirect.com
    Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice
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    sciencedirect.com/science/article/pii/S2666166725003132
  38. May 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Specific targeting of brain endothelial cells using enhancer AAV vectors
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    sciencedirect.com/science/article/pii/S089662732500251X
  40. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice
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    sciencedirect.com/science/article/pii/S1525001625002965
  41. Mar 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Use of an oversized AAV8 vector for CPS1 deficiency results in long-term survival and ammonia control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11905892/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876347/
  44. Jan 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rational engineering of minimally immunogenic nucleases for gene therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11696374/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting pleuro-alveolar junctions reverses lung fibrosis in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11696612/
  47. Dec 2024
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TXNIP regulates pulmonary inflammation induced by Asian sand dust
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671764/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11650319/
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202406191
  51. Nov 2024
  52. www.sciencedirect.com www.sciencedirect.com
    Modulation of AAV transduction and integration targeting by topoisomerase poisons
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    sciencedirect.com/science/article/pii/S2329050124001803
  53. Sep 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11347664/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365433/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator
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    ncbi.nlm.nih.gov/pmc/articles/PMC11413375/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple and highly specific targeting of resident microglia with adeno-associated virus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407971/
  58. Aug 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267048/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo interaction screening reveals liver-derived constraints to metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306111/
  61. Jun 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11160762/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P2Y13 receptor deficiency favors adipose tissue lipolysis and worsens insulin resistance and fatty liver disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141875/
  64. May 2024
  65. www.biorxiv.org www.biorxiv.org
    Optimal AAV capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex
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    biorxiv.org/content/10.1101/2024.05.09.593444v1
  66. www.nature.com www.nature.com
    Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins
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    nature.com/articles/s41590-024-01820-1
  67. Apr 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962888/
  69. Mar 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER
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    ncbi.nlm.nih.gov/pmc/articles/PMC10939742/
  71. Feb 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770082/
  73. Apr 2023
  74. www.sciencedirect.com www.sciencedirect.com
    Berberine activates PPARδ and promotes gut microbiota-derived butyric acid to suppress hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S0944711323002039
  75. Nov 2022
  76. www.sciencedirect.com www.sciencedirect.com
    Neural circuit-specific gene manipulation in mouse brain in vivo using split-intein-mediated split-Cre system
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    sciencedirect.com/science/article/pii/S2666166722006876
  77. Jun 2022
  78. www.sciencedirect.com www.sciencedirect.com
    Neural circuit pathology driven by Shank3 mutation disrupts social behaviors
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    sciencedirect.com/science/article/pii/S2211124722006817
  79. Nov 2021
  80. www.sciencedirect.com www.sciencedirect.com
    Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
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    sciencedirect.com/science/article/pii/S221112472101411X
  81. Sep 2021
  82. www.sciencedirect.com www.sciencedirect.com
    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    sciencedirect.com/science/article/pii/S0092867421010527
  83. www.sciencedirect.com www.sciencedirect.com
    Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival
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    sciencedirect.com/science/article/pii/S2211124721011517
  84. Jan 2021
  85. www.frontiersin.org www.frontiersin.org
    Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness
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    frontiersin.org/article/10.3389/fnmol.2020.600051/full