149 Matching Annotations
  1. Jan 2026
  2. www.biorxiv.org www.biorxiv.org
    Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy
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    biorxiv.org/content/10.64898/2026.01.09.698633v1
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Senescent cells promote viral infection-associated inflammation and tissue damage through a robust NF-κB pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12560573/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12542959/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chronologically distributed transfection improves AAV2 and AAV2/8 capsid filling and reveals assembly schedule divergence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12554105/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-22 Exacerbates Coxsackievirus Type B3-Induced Pancreatitis by Elevating Viral Replication Through STAT3 Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12599472/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rat somatic genome editing enables ER+ breast cancer modeling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12458290/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thioredoxin-interacting protein as a crucial regulator in asthma exacerbation induced by copper oxide nanoparticles in a mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12450567/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Modeling of Human Dorsal Root Ganglion Neurons for GCaMP6-Based Calcium Imaging of Sensory Responses to HSV-1 Infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12513575/
  11. www.sciencedirect.com www.sciencedirect.com
    Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex
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    sciencedirect.com/science/article/pii/S2589004225022199
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623870/
  13. Oct 2025
  14. www.biorxiv.org www.biorxiv.org
    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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    biorxiv.org/content/10.1101/2025.10.14.682478v1
  15. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225019455-main-html.html
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    54.241.53.176/7d5086fb86ff169c66d0f1c84a2767681807c1ce/1-s2.0-S2589004225019455-main-html.html
  16. Sep 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12441120/
  18. www.biorxiv.org www.biorxiv.org
    Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation
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    biorxiv.org/content/10.1101/2025.09.15.676326v1
  19. www.biorxiv.org www.biorxiv.org
    GephyrinΔ199-233 - an epileptogenic microdeletion
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    biorxiv.org/content/10.1101/2025.08.26.672322v1
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410343/
  22. Aug 2025
  23. www.sciencedirect.com www.sciencedirect.com
    Hepatocyte metabolic adaptations during pregnancy and lactation
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    sciencedirect.com/science/article/pii/S0092867425009213
  24. www.nature.com www.nature.com
    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    nature.com/articles/s41593-025-02043-9
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11780352/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265543/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272419/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained high expression of human FVII following AAV8-mediated gene delivery in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282199/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unveiling Small Non‐Coding RNA Dynamics During Recombinant Adeno‐Associated Virus Production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329270/
  30. Jul 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236521/
  32. 52.53.155.43 52.53.155.43
    matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
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    52.53.155.43/0eec343059498565fba813ed54e166140d5ee93f/matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
  33. www.journal-of-hepatology.eu www.journal-of-hepatology.eu
    Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
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    journal-of-hepatology.eu/article/S0168-8278(25)02320-7/fulltext
  34. elifesciences.org elifesciences.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    elifesciences.org/reviewed-preprints/106778
  35. Jun 2025
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185343/
  37. www.sciencedirect.com www.sciencedirect.com
    Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice
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    sciencedirect.com/science/article/pii/S2666166725003132
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162853/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of hydrophilic interaction liquid chromatography and top-down mass spectrometry for characterisation of adeno-associated virus capsid proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122587/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclophilin J Reprograms Tumor-associated Macrophages to Exert an Anti-tumor Effect in Liver Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160919/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137126/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12152525/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCL12 engages cortical inhibitory neurons to enhance dendritic spine plasticity and structured network activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160403/
  44. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/62bf11b5160e5e2b06d12f814719cb59c71e75c9/PDF-html.html
  45. May 2025
  46. www.sciencedirect.com www.sciencedirect.com
    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627325003459
  47. link.springer.com link.springer.com
    SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes
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    link.springer.com/article/10.1007/s12035-025-05036-8
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024971/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050299/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986041/
  51. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice
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    sciencedirect.com/science/article/pii/S1525001625002965
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11987650/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060515/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A humanized Gs-coupled DREADD for circuit and behavior modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015759/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The G protein modifier KCTD5 tunes the decoding of neuromodulatory signals necessary for motor function in striatal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021292/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predicting adenine base editing efficiencies in different cellular contexts by deep learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049829/
  59. Apr 2025
  60. 52.53.155.43 52.53.155.43
    1-s2.0-S1525001625002795-main-html.html
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    52.53.155.43/50ee16a498584d049fed89adec56a062179dbf25/PDF-html.html
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225003700-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951025/
  63. www.biorxiv.org www.biorxiv.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    biorxiv.org/content/10.1101/2025.03.24.645101v1
  64. Mar 2025
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cardiac-Specific Gene Editing via an AAV9-Tnnt2-SaCas9-miR122TS Vector
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    pmc.ncbi.nlm.nih.gov/articles/PMC11896767/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Use of an oversized AAV8 vector for CPS1 deficiency results in long-term survival and ammonia control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11905892/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766445/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839100/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761689/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876347/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11860254/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882927/
  73. Feb 2025
  74. 52.53.155.43 52.53.155.43
    DB23-0357 Supplemental_Materials-html.html
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    52.53.155.43/43b40e94010b1324172352642c136e918543fae0/DB23-0357 Supplemental_Materials-html.html
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.
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    pmc.ncbi.nlm.nih.gov/articles/PMC11340281/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842818/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789068/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11814140/
  79. www.sciencedirect.com www.sciencedirect.com
    The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses
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    sciencedirect.com/science/article/pii/S2211124725000270
  80. Jan 2025
  81. www.sciencedirect.com www.sciencedirect.com
    Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection
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    sciencedirect.com/science/article/pii/S1074761325000299
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766350/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rational engineering of minimally immunogenic nucleases for gene therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11696374/
  84. Dec 2024
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TXNIP regulates pulmonary inflammation induced by Asian sand dust
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671764/
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11650319/
  87. www.nature.com www.nature.com
    Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells
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    nature.com/articles/s41593-024-01826-w
  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202406191
  89. Nov 2024
  90. www.sciencedirect.com www.sciencedirect.com
    Modulation of AAV transduction and integration targeting by topoisomerase poisons
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    sciencedirect.com/science/article/pii/S2329050124001803
  91. Sep 2024
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343251/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365433/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11434121/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11374875/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385518/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHISA3 Reprograms Tumor‐Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  101. Aug 2024
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  109. Jun 2024
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  114. May 2024
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  121. Apr 2024
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  123. Mar 2024
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  132. Feb 2024
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  135. Jan 2024
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  137. Dec 2023
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  139. Nov 2023
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  142. Aug 2023
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  144. Jul 2023
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  147. Jun 2023
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  150. May 2023
  151. www.authorea.com www.authorea.com
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  152. Apr 2023
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  155. Mar 2023
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  157. Feb 2023
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    An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice
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  159. Jan 2023
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  162. Dec 2022
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  164. Nov 2022
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  166. Jul 2022
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  168. Jun 2022
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  171. May 2022
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  173. Mar 2022
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  175. Jan 2022
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  177. Nov 2021
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    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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  180. Oct 2021
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    A Fast, Aqueous, Reversible Three-Day Tissue Clearing Method for Adult and Embryonic Mouse Brain and Whole Body
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  182. Sep 2021
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  185. Jul 2021
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    Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models
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  187. Apr 2021
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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  189. Feb 2021
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    A simple adeno-associated virus-based approach for the generation of cardiac genetic models in rats
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  191. Dec 2020
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    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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  193. Jan 2020
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    Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
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