139 Matching Annotations
  1. Last 7 days
  2. www.biorxiv.org www.biorxiv.org
    Adolescent Alcohol Exposure Disrupts Astrocyte-Synaptic Structural And Functional Coupling In The Male Dorsal Hippocampus
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    biorxiv.org/content/10.1101/2025.10.14.682478v1
  3. Oct 2025
  4. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225019455-main-html.html
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  5. Sep 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
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    pmc.ncbi.nlm.nih.gov/articles/PMC12441120/
  7. www.biorxiv.org www.biorxiv.org
    Long non-coding RNA Cerox1 targets components of the mitochondrial electron transport chain to regulate the memory impairment caused by sleep deprivation
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    biorxiv.org/content/10.1101/2025.09.15.676326v1
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    GephyrinΔ199-233 - an epileptogenic microdeletion
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    biorxiv.org/content/10.1101/2025.08.26.672322v1
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405439/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of LC-MS methods for AAV capsid protein quantification and host cell protein profiling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410343/
  11. Aug 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Hepatocyte metabolic adaptations during pregnancy and lactation
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    sciencedirect.com/science/article/pii/S0092867425009213
  13. www.nature.com www.nature.com
    CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
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    nature.com/articles/s41593-025-02043-9
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11780352/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265543/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Directed evolution of novel AAV variants using the MCMS library for enhanced CNS tropism and reduced liver targeting in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12272419/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained high expression of human FVII following AAV8-mediated gene delivery in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12282199/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unveiling Small Non‐Coding RNA Dynamics During Recombinant Adeno‐Associated Virus Production
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329270/
  19. Jul 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236521/
  21. 52.53.155.43 52.53.155.43
    matienzo-et-al-2025-adipocyte-specific-modulation-of-11β-hsd-enzymes-for-the-treatment-of-obesity-in-male-mice-html.html
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  22. www.journal-of-hepatology.eu www.journal-of-hepatology.eu
    Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation
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    journal-of-hepatology.eu/article/S0168-8278(25)02320-7/fulltext
  23. elifesciences.org elifesciences.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    elifesciences.org/reviewed-preprints/106778
  24. Jun 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12185343/
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    Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice
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    sciencedirect.com/science/article/pii/S2666166725003132
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High-purity AAV vector production utilizing recombination-dependent minicircle formation and genetic coupling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162853/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combination of hydrophilic interaction liquid chromatography and top-down mass spectrometry for characterisation of adeno-associated virus capsid proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC12122587/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclophilin J Reprograms Tumor-associated Macrophages to Exert an Anti-tumor Effect in Liver Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160919/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137126/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing
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    pmc.ncbi.nlm.nih.gov/articles/PMC12152525/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCL12 engages cortical inhibitory neurons to enhance dendritic spine plasticity and structured network activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12160403/
  33. 52.53.155.43 52.53.155.43
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  34. May 2025
  35. www.sciencedirect.com www.sciencedirect.com
    GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627325003459
  36. link.springer.com link.springer.com
    SFRS8 Regulates Memory by Modulating RNA Splicing of Synaptic Genes
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    link.springer.com/article/10.1007/s12035-025-05036-8
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung Organoids from hiPSCs Can Be Efficiently Transduced by Recombinant Adeno-Associated Viral and Adenoviral Vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12024971/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social behavior in male mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050299/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption
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    pmc.ncbi.nlm.nih.gov/articles/PMC11986041/
  40. www.sciencedirect.com www.sciencedirect.com
    Small molecule inhibition of SUMOylation increases expression from AAV vectors both during and after initial transduction in mice
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    sciencedirect.com/science/article/pii/S1525001625002965
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11987650/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Krüppel-like factor 5 remodels lipid metabolism in exercised skeletal muscle
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060515/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A humanized Gs-coupled DREADD for circuit and behavior modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12015759/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The G protein modifier KCTD5 tunes the decoding of neuromodulatory signals necessary for motor function in striatal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12021292/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Predicting adenine base editing efficiencies in different cellular contexts by deep learning
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    pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049787/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12049829/
  48. Apr 2025
  49. 52.53.155.43 52.53.155.43
    1-s2.0-S1525001625002795-main-html.html
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  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225003700-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951025/
  52. www.biorxiv.org www.biorxiv.org
    SIRT2 protects against Japanese encephalitis virus infection in mice
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    biorxiv.org/content/10.1101/2025.03.24.645101v1
  53. Mar 2025
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cardiac-Specific Gene Editing via an AAV9-Tnnt2-SaCas9-miR122TS Vector
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    pmc.ncbi.nlm.nih.gov/articles/PMC11896767/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Use of an oversized AAV8 vector for CPS1 deficiency results in long-term survival and ammonia control
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    pmc.ncbi.nlm.nih.gov/articles/PMC11905892/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766445/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex
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    pmc.ncbi.nlm.nih.gov/articles/PMC11839100/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11761689/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11876347/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11860254/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11882927/
  62. Feb 2025
  63. 52.53.155.43 52.53.155.43
    DB23-0357 Supplemental_Materials-html.html
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.
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    pmc.ncbi.nlm.nih.gov/articles/PMC11340281/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842818/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Calcineurin governs baseline and homeostatic regulations of non–rapid eye movement sleep in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789068/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11814140/
  68. www.sciencedirect.com www.sciencedirect.com
    The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses
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    sciencedirect.com/science/article/pii/S2211124725000270
  69. Jan 2025
  70. www.sciencedirect.com www.sciencedirect.com
    Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection
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    sciencedirect.com/science/article/pii/S1074761325000299
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference
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    pmc.ncbi.nlm.nih.gov/articles/PMC11766350/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Rational engineering of minimally immunogenic nucleases for gene therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11696374/
  73. Dec 2024
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TXNIP regulates pulmonary inflammation induced by Asian sand dust
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671764/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11650319/
  76. www.nature.com www.nature.com
    Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells
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    nature.com/articles/s41593-024-01826-w
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202406191
  78. Nov 2024
  79. www.sciencedirect.com www.sciencedirect.com
    Modulation of AAV transduction and integration targeting by topoisomerase poisons
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    sciencedirect.com/science/article/pii/S2329050124001803
  80. Sep 2024
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
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    ncbi.nlm.nih.gov/pmc/articles/PMC11343251/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365433/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HSF5 Deficiency Causes Male Infertility Involving Spermatogenic Arrest at Meiotic Prophase I in Humans and Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11434121/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11374875/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11385518/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHISA3 Reprograms Tumor‐Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11423144/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical targeting of the cannabinoid type 1 receptor impacts the crosstalk between immune cells and islets to reduce insulitis in humans
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410908/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simple and highly specific targeting of resident microglia with adeno-associated virus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407971/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of KDM6B mosaic brain knockout on synaptic function and behavior
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    ncbi.nlm.nih.gov/pmc/articles/PMC11369245/
  90. Aug 2024
  91. www.sciencedirect.com www.sciencedirect.com
    Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes
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    sciencedirect.com/science/article/pii/S2211124724009872
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell discovery of m6A RNA modifications in the hippocampus
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293556/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310333/
  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Adenosine A2B receptors differently modulate oligodendrogliogenesis and myelination depending on their cellular localization
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    onlinelibrary.wiley.com/doi/10.1002/glia.24593
  95. www.cell.com www.cell.com
    Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
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    cell.com/cell-reports/fulltext/S2211-1247(24)00756-3
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS
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    ncbi.nlm.nih.gov/pmc/articles/PMC10897598/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Streamlined Adeno-Associated Virus Production Using Suspension HEK293T Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10875358/
  98. Jun 2024
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Localized translation and sarcomere maintenance requires ribosomal protein SA in mice
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  103. May 2024
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    Targeting low levels of MIF expression as a potential therapeutic strategy for ALS
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  110. Apr 2024
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  112. Mar 2024
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    Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection
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    Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
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    Modular vector assembly enables rapid assessment of emerging CRISPR technologies
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    Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice
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  121. Feb 2024
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  124. Jan 2024
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  126. Dec 2023
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  128. Nov 2023
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  131. Aug 2023
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    KMT2C knockout generates ASD-like behaviors in mice
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  133. Jul 2023
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  136. Jun 2023
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  139. May 2023
  140. www.authorea.com www.authorea.com
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  141. Apr 2023
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  144. Mar 2023
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    The molecular mechanism and physiological role of silent nociceptor activation
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  146. Feb 2023
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    An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice
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  148. Jan 2023
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    Recombinant Adeno-associated Viral Vectors Serotypes 6 and 9 are Able to Transduce Human Tracheal Epithelial Cells but Not Human Induced Pluripotent Stem Cells
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    Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants
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  151. Dec 2022
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  153. Nov 2022
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  155. Jul 2022
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  157. Jun 2022
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    Targeting miR-30d reverses pathological cardiac hypertrophy
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  160. May 2022
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  162. Mar 2022
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    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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  164. Jan 2022
  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  166. Nov 2021
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    OGDHL Ameliorates Cognitive Impairment and Alzheimer's Disease-Like Pathology via Activating Wnt/β-catenin signaling in Alzheimer's Disease Mice
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  169. Oct 2021
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    A Fast, Aqueous, Reversible Three-Day Tissue Clearing Method for Adult and Embryonic Mouse Brain and Whole Body
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  171. Sep 2021
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    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    Compact RNA editors with small Cas13 proteins
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  174. Jul 2021
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    Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models
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  176. Apr 2021
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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  178. Feb 2021
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    A simple adeno-associated virus-based approach for the generation of cardiac genetic models in rats
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  180. Dec 2020
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    CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
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  182. Jan 2020
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    Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
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